TY - JOUR
T1 - Arterial Catheterization and Infection
T2 - Toll-like Receptors in Defense against Microorganisms and Therapeutic Implications
AU - Hambsch, Zakary J.
AU - Kerfeld, Mitchell J.
AU - Kirkpatrick, Daniel R.
AU - Mcentire, Dan M.
AU - Reisbig, Mark D.
AU - Youngblood, Charles F.
AU - Agrawal, Devendra K.
N1 - Funding Information:
This work was supported by research grants R01HL116042, R01HL112597, and R01HL120659 from the National Institutes of Health, USA to D.K. Agrawal. The content of this review is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
Publisher Copyright:
© 2015 Wiley Periodicals, Inc.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Radial artery catheterization has become a preferred route over femoral artery catheterization, in order to monitor the blood pressure of hemodynamically unstable patients or for repeated sampling of arterial blood gases. While the incidence of catheter-related infection is lower in the radial artery than the femoral artery, infection remains a major issue that requires attention. In this review of the literature, we discuss infectious complications of radial artery catheterization, with a focus on various risk factors and establishing the most common causative agents. We also critically review the role of the innate immune system involving Toll-like receptors (TLRs) in host-defense, with the goal of establishing a common pathway used by the innate immune system via TLRs to combat the pathogens that most commonly cause infection in radial artery catheterization. If this pathway can be therapeutically manipulated to preemptively attack pathogenic agents, immunomodulation may be an option in reducing the incidence of infection in this procedure.
AB - Radial artery catheterization has become a preferred route over femoral artery catheterization, in order to monitor the blood pressure of hemodynamically unstable patients or for repeated sampling of arterial blood gases. While the incidence of catheter-related infection is lower in the radial artery than the femoral artery, infection remains a major issue that requires attention. In this review of the literature, we discuss infectious complications of radial artery catheterization, with a focus on various risk factors and establishing the most common causative agents. We also critically review the role of the innate immune system involving Toll-like receptors (TLRs) in host-defense, with the goal of establishing a common pathway used by the innate immune system via TLRs to combat the pathogens that most commonly cause infection in radial artery catheterization. If this pathway can be therapeutically manipulated to preemptively attack pathogenic agents, immunomodulation may be an option in reducing the incidence of infection in this procedure.
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U2 - 10.1111/cts.12320
DO - 10.1111/cts.12320
M3 - Article
C2 - 26271949
AN - SCOPUS:84952980436
VL - 8
SP - 857
EP - 870
JO - Clinical and Translational Science
JF - Clinical and Translational Science
SN - 1752-8054
IS - 6
ER -