Arterial Catheterization and Infection

Toll-like Receptors in Defense against Microorganisms and Therapeutic Implications

Zakary J. Hambsch, Mitchell J. Kerfeld, Daniel R. Kirkpatrick, Dan M. Mcentire, Mark Reisbig, Charles Youngblood, Devendra K. Agrawal

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Radial artery catheterization has become a preferred route over femoral artery catheterization, in order to monitor the blood pressure of hemodynamically unstable patients or for repeated sampling of arterial blood gases. While the incidence of catheter-related infection is lower in the radial artery than the femoral artery, infection remains a major issue that requires attention. In this review of the literature, we discuss infectious complications of radial artery catheterization, with a focus on various risk factors and establishing the most common causative agents. We also critically review the role of the innate immune system involving Toll-like receptors (TLRs) in host-defense, with the goal of establishing a common pathway used by the innate immune system via TLRs to combat the pathogens that most commonly cause infection in radial artery catheterization. If this pathway can be therapeutically manipulated to preemptively attack pathogenic agents, immunomodulation may be an option in reducing the incidence of infection in this procedure.

Original languageEnglish
Pages (from-to)857-870
Number of pages14
JournalClinical and Translational Science
Volume8
Issue number6
DOIs
StatePublished - Dec 1 2015

Fingerprint

Radial Artery
Immune system
Toll-Like Receptors
Catheterization
Microorganisms
Catheters
Blood pressure
Pathogens
Femoral Artery
Infection
Immune System
Blood
Gases
Blood Pressure Monitors
Sampling
Catheter-Related Infections
Immunomodulation
Incidence
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Arterial Catheterization and Infection : Toll-like Receptors in Defense against Microorganisms and Therapeutic Implications. / Hambsch, Zakary J.; Kerfeld, Mitchell J.; Kirkpatrick, Daniel R.; Mcentire, Dan M.; Reisbig, Mark; Youngblood, Charles; Agrawal, Devendra K.

In: Clinical and Translational Science, Vol. 8, No. 6, 01.12.2015, p. 857-870.

Research output: Contribution to journalArticle

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