Aryl-hydrocarbon hydroxylase activity in lymphocytes from lung cancer patients and normal controls

H. A. Guirgis, H. T. Lynch, T. Mate, R. E. Harris, I. Wells, L. Caha, J. Anderson, K. Maloney, L. Rankin

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Abstract

A radiometric assay for the determination of AHH activity in lymphocytes is described. Subjects included eleven male patients with histologically verified lung cancer (nine squamous cell car-cinoma and two adenocarcinoma) and eleven age-and sex-matched controls. Lung cancer patients exhibited considerably greater varia-tion and elevated levels of both AHH activity per se and AHH activity adjusted for total cellular DNA than control individuals. Methodology for AHH determinations and implications for lung cancer epidemiology and control are discussed.

Original languageEnglish (US)
Pages (from-to)105-109
Number of pages5
JournalOncology (Switzerland)
Volume33
Issue number3
DOIs
StatePublished - Jan 1 1976

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Guirgis, H. A., Lynch, H. T., Mate, T., Harris, R. E., Wells, I., Caha, L., Anderson, J., Maloney, K., & Rankin, L. (1976). Aryl-hydrocarbon hydroxylase activity in lymphocytes from lung cancer patients and normal controls. Oncology (Switzerland), 33(3), 105-109. https://doi.org/10.1159/000225116