Aryl-hydrocarbon hydroxylase activity in lymphocytes from lung cancer patients and normal controls

H. A. Guirgis, Henry T. Lynch, T. Mate, R. E. Harris, I. Wells, L. Caha, J. Anderson, K. Maloney, L. Rankin

Research output: Contribution to journalArticle

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Abstract

A radiometric assay for the determination of AHH activity in lymphocytes is described. Subjects included eleven male patients with histologically verified lung cancer (nine squamous cell car-cinoma and two adenocarcinoma) and eleven age-and sex-matched controls. Lung cancer patients exhibited considerably greater varia-tion and elevated levels of both AHH activity per se and AHH activity adjusted for total cellular DNA than control individuals. Methodology for AHH determinations and implications for lung cancer epidemiology and control are discussed.

Original languageEnglish
Pages (from-to)105-109
Number of pages5
JournalOncology
Volume33
Issue number3
DOIs
StatePublished - 1976

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Aryl Hydrocarbon Hydroxylases
Lung Neoplasms
Lymphocytes
Epidemiology
Adenocarcinoma
Epithelial Cells
DNA

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Guirgis, H. A., Lynch, H. T., Mate, T., Harris, R. E., Wells, I., Caha, L., ... Rankin, L. (1976). Aryl-hydrocarbon hydroxylase activity in lymphocytes from lung cancer patients and normal controls. Oncology, 33(3), 105-109. https://doi.org/10.1159/000225116

Aryl-hydrocarbon hydroxylase activity in lymphocytes from lung cancer patients and normal controls. / Guirgis, H. A.; Lynch, Henry T.; Mate, T.; Harris, R. E.; Wells, I.; Caha, L.; Anderson, J.; Maloney, K.; Rankin, L.

In: Oncology, Vol. 33, No. 3, 1976, p. 105-109.

Research output: Contribution to journalArticle

Guirgis, HA, Lynch, HT, Mate, T, Harris, RE, Wells, I, Caha, L, Anderson, J, Maloney, K & Rankin, L 1976, 'Aryl-hydrocarbon hydroxylase activity in lymphocytes from lung cancer patients and normal controls', Oncology, vol. 33, no. 3, pp. 105-109. https://doi.org/10.1159/000225116
Guirgis, H. A. ; Lynch, Henry T. ; Mate, T. ; Harris, R. E. ; Wells, I. ; Caha, L. ; Anderson, J. ; Maloney, K. ; Rankin, L. / Aryl-hydrocarbon hydroxylase activity in lymphocytes from lung cancer patients and normal controls. In: Oncology. 1976 ; Vol. 33, No. 3. pp. 105-109.
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