Aryl-hydrocarbon hydroxylase activity in lymphocytes from lung cancer patients and normal controls

H. A. Guirgis; H. T. Lynch; T. Mate; R. E. Harris; I. Wells; L. Caha; J. Anderson; K. Maloney; L. Rankin

doi:10.1159/000225116

Aryl-hydrocarbon hydroxylase activity in lymphocytes from lung cancer patients and normal controls

H. A. Guirgis, H. T. Lynch, T. Mate, R. E. Harris, I. Wells, L. Caha, J. Anderson, K. Maloney, L. Rankin

Department of Preventive Medicine

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

A radiometric assay for the determination of AHH activity in lymphocytes is described. Subjects included eleven male patients with histologically verified lung cancer (nine squamous cell car-cinoma and two adenocarcinoma) and eleven age-and sex-matched controls. Lung cancer patients exhibited considerably greater varia-tion and elevated levels of both AHH activity per se and AHH activity adjusted for total cellular DNA than control individuals. Methodology for AHH determinations and implications for lung cancer epidemiology and control are discussed.

Original language	English (US)
Pages (from-to)	105-109
Number of pages	5
Journal	Oncology (Switzerland)
Volume	33
Issue number	3
DOIs	https://doi.org/10.1159/000225116
State	Published - 1976

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1159/000225116

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AU - Guirgis, H. A.

AU - Lynch, H. T.

AU - Mate, T.

AU - Harris, R. E.

AU - Wells, I.

AU - Caha, L.

AU - Anderson, J.

AU - Maloney, K.

AU - Rankin, L.

PY - 1976

Y1 - 1976

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AB - A radiometric assay for the determination of AHH activity in lymphocytes is described. Subjects included eleven male patients with histologically verified lung cancer (nine squamous cell car-cinoma and two adenocarcinoma) and eleven age-and sex-matched controls. Lung cancer patients exhibited considerably greater varia-tion and elevated levels of both AHH activity per se and AHH activity adjusted for total cellular DNA than control individuals. Methodology for AHH determinations and implications for lung cancer epidemiology and control are discussed.

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Aryl-hydrocarbon hydroxylase activity in lymphocytes from lung cancer patients and normal controls

Abstract

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