Assessing vitamin D status

Robert P. Heaney

doi:10.1097/MCO.0b013e328348ed85

Assessing vitamin D status

Robert P. Heaney

Department of Medicine

Research output: Contribution to journal › Review article › peer-review

42 Scopus citations

Abstract

Purpose of Review: To characterize methods evaluating and to summarize studies linking various serum 25-hydroxyvitamin D [25(OH)D] concentrations with health status. Recent Findings: Elucidation of the cell-biologic mechanism of vitamin D action, and numerous clinical trials and observational studies relating vitamin D status to health and disease. Conclusion: The distinction between deficiency and insufficiency is not useful or necessary. Serum 25(OH)D values below 120 nmol/l (48 ng/ml) are associated with preventable disease and are therefore indicative of deficiency. The upper limit of the normal range can be set at 225 nmol/l (90 ng/ml), although toxicity is rare below 500 nmol/l (200 ng/ml).

Original language	English (US)
Pages (from-to)	440-444
Number of pages	5
Journal	Current Opinion in Clinical Nutrition and Metabolic Care
Volume	14
Issue number	5
DOIs	https://doi.org/10.1097/MCO.0b013e328348ed85
State	Published - Sep 1 2011

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
Nutrition and Dietetics

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title = "Assessing vitamin D status",

abstract = "Purpose of Review: To characterize methods evaluating and to summarize studies linking various serum 25-hydroxyvitamin D [25(OH)D] concentrations with health status. Recent Findings: Elucidation of the cell-biologic mechanism of vitamin D action, and numerous clinical trials and observational studies relating vitamin D status to health and disease. Conclusion: The distinction between deficiency and insufficiency is not useful or necessary. Serum 25(OH)D values below 120 nmol/l (48 ng/ml) are associated with preventable disease and are therefore indicative of deficiency. The upper limit of the normal range can be set at 225 nmol/l (90 ng/ml), although toxicity is rare below 500 nmol/l (200 ng/ml).",

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AB - Purpose of Review: To characterize methods evaluating and to summarize studies linking various serum 25-hydroxyvitamin D [25(OH)D] concentrations with health status. Recent Findings: Elucidation of the cell-biologic mechanism of vitamin D action, and numerous clinical trials and observational studies relating vitamin D status to health and disease. Conclusion: The distinction between deficiency and insufficiency is not useful or necessary. Serum 25(OH)D values below 120 nmol/l (48 ng/ml) are associated with preventable disease and are therefore indicative of deficiency. The upper limit of the normal range can be set at 225 nmol/l (90 ng/ml), although toxicity is rare below 500 nmol/l (200 ng/ml).

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