Assessment of prognostic factors after primary tumor resection in metastatic colon cancer patients

A Veteran's Affairs Central Cancer Registry (VACCR) analysis, 1995-2008

Wilson I. Gonsalves, Joseph Wolpert, Tsewang Tashi, Apar K. Ganti, Shanmuga Subbiah, Charles Ternent, Peter T. Silberstein

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Background Resection of the primary tumor in metastatic colon cancer may occur for palliation of bleeding or obstruction despite distant metastases. This study evaluates clinicopathologic features that serve as prognostic markers in those patients with stage IV colon cancer who undergo resection of their primary tumor. Methods Retrospective analysis of stage IV colon cancer patients who underwent surgical resection of the primary tumor from 1995 to 2008 was done via the Veteran's Affairs Central Cancer Registry. Age, Charlson co-morbidity index score, extent of metastases, sex, number of lymph nodes examined, lymph node ratio (LNR), type of surgery, use of adjuvant chemotherapy, primary tumor site, and grade were studied with respect to overall survival by using log-rank and Kaplan-Meier analysis. Results There were 2,625 patients with stage IV colon cancer who had primary tumor resection. Age at diagnosis, Charlson co-morbidity index score, lymph node ratio, and use of chemotherapy were found to be independent predictors of survival by multivariate analysis. Conclusion Clinicopathologic factors such as LNR, use of chemotherapy, age, co-morbidities, site of primary colon tumor, and number of sites of metastasis are all independent predictors of overall survival in patients who undergo primary colon tumor resection in the metastatic setting. J. Surg. Oncol. 2012; 106:486-490. © 2012 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)486-490
Number of pages5
JournalJournal of Surgical Oncology
Volume106
Issue number4
DOIs
StatePublished - Sep 15 2012

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Veterans
Colonic Neoplasms
Registries
Neoplasms
Lymph Nodes
Neoplasm Metastasis
Morbidity
Colon
Drug Therapy
Survival
Kaplan-Meier Estimate
Adjuvant Chemotherapy
Survival Analysis
Multivariate Analysis
Hemorrhage

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Assessment of prognostic factors after primary tumor resection in metastatic colon cancer patients : A Veteran's Affairs Central Cancer Registry (VACCR) analysis, 1995-2008. / Gonsalves, Wilson I.; Wolpert, Joseph; Tashi, Tsewang; Ganti, Apar K.; Subbiah, Shanmuga; Ternent, Charles; Silberstein, Peter T.

In: Journal of Surgical Oncology, Vol. 106, No. 4, 15.09.2012, p. 486-490.

Research output: Contribution to journalReview article

Gonsalves, Wilson I. ; Wolpert, Joseph ; Tashi, Tsewang ; Ganti, Apar K. ; Subbiah, Shanmuga ; Ternent, Charles ; Silberstein, Peter T. / Assessment of prognostic factors after primary tumor resection in metastatic colon cancer patients : A Veteran's Affairs Central Cancer Registry (VACCR) analysis, 1995-2008. In: Journal of Surgical Oncology. 2012 ; Vol. 106, No. 4. pp. 486-490.
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abstract = "Background Resection of the primary tumor in metastatic colon cancer may occur for palliation of bleeding or obstruction despite distant metastases. This study evaluates clinicopathologic features that serve as prognostic markers in those patients with stage IV colon cancer who undergo resection of their primary tumor. Methods Retrospective analysis of stage IV colon cancer patients who underwent surgical resection of the primary tumor from 1995 to 2008 was done via the Veteran's Affairs Central Cancer Registry. Age, Charlson co-morbidity index score, extent of metastases, sex, number of lymph nodes examined, lymph node ratio (LNR), type of surgery, use of adjuvant chemotherapy, primary tumor site, and grade were studied with respect to overall survival by using log-rank and Kaplan-Meier analysis. Results There were 2,625 patients with stage IV colon cancer who had primary tumor resection. Age at diagnosis, Charlson co-morbidity index score, lymph node ratio, and use of chemotherapy were found to be independent predictors of survival by multivariate analysis. Conclusion Clinicopathologic factors such as LNR, use of chemotherapy, age, co-morbidities, site of primary colon tumor, and number of sites of metastasis are all independent predictors of overall survival in patients who undergo primary colon tumor resection in the metastatic setting. J. Surg. Oncol. 2012; 106:486-490. {\circledC} 2012 Wiley Periodicals, Inc.",
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T1 - Assessment of prognostic factors after primary tumor resection in metastatic colon cancer patients

T2 - A Veteran's Affairs Central Cancer Registry (VACCR) analysis, 1995-2008

AU - Gonsalves, Wilson I.

AU - Wolpert, Joseph

AU - Tashi, Tsewang

AU - Ganti, Apar K.

AU - Subbiah, Shanmuga

AU - Ternent, Charles

AU - Silberstein, Peter T.

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N2 - Background Resection of the primary tumor in metastatic colon cancer may occur for palliation of bleeding or obstruction despite distant metastases. This study evaluates clinicopathologic features that serve as prognostic markers in those patients with stage IV colon cancer who undergo resection of their primary tumor. Methods Retrospective analysis of stage IV colon cancer patients who underwent surgical resection of the primary tumor from 1995 to 2008 was done via the Veteran's Affairs Central Cancer Registry. Age, Charlson co-morbidity index score, extent of metastases, sex, number of lymph nodes examined, lymph node ratio (LNR), type of surgery, use of adjuvant chemotherapy, primary tumor site, and grade were studied with respect to overall survival by using log-rank and Kaplan-Meier analysis. Results There were 2,625 patients with stage IV colon cancer who had primary tumor resection. Age at diagnosis, Charlson co-morbidity index score, lymph node ratio, and use of chemotherapy were found to be independent predictors of survival by multivariate analysis. Conclusion Clinicopathologic factors such as LNR, use of chemotherapy, age, co-morbidities, site of primary colon tumor, and number of sites of metastasis are all independent predictors of overall survival in patients who undergo primary colon tumor resection in the metastatic setting. J. Surg. Oncol. 2012; 106:486-490. © 2012 Wiley Periodicals, Inc.

AB - Background Resection of the primary tumor in metastatic colon cancer may occur for palliation of bleeding or obstruction despite distant metastases. This study evaluates clinicopathologic features that serve as prognostic markers in those patients with stage IV colon cancer who undergo resection of their primary tumor. Methods Retrospective analysis of stage IV colon cancer patients who underwent surgical resection of the primary tumor from 1995 to 2008 was done via the Veteran's Affairs Central Cancer Registry. Age, Charlson co-morbidity index score, extent of metastases, sex, number of lymph nodes examined, lymph node ratio (LNR), type of surgery, use of adjuvant chemotherapy, primary tumor site, and grade were studied with respect to overall survival by using log-rank and Kaplan-Meier analysis. Results There were 2,625 patients with stage IV colon cancer who had primary tumor resection. Age at diagnosis, Charlson co-morbidity index score, lymph node ratio, and use of chemotherapy were found to be independent predictors of survival by multivariate analysis. Conclusion Clinicopathologic factors such as LNR, use of chemotherapy, age, co-morbidities, site of primary colon tumor, and number of sites of metastasis are all independent predictors of overall survival in patients who undergo primary colon tumor resection in the metastatic setting. J. Surg. Oncol. 2012; 106:486-490. © 2012 Wiley Periodicals, Inc.

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