Assessment of trabecular and cortical architecture and mechanical competence of bone by high-resolution peripheral computed tomography: Comparison with transiliac bone biopsy

A. Cohen, D. W. Dempster, R. Müller, X. E. Guo, T. L. Nickolas, X. S. Liu, X. H. Zhang, A. J. Wirth, G. H. Van Lenthe, T. Kohler, D. J. McMahon, H. Zhou, M. R. Rubin, J. P. Bilezikian, Joan M. Lappe, Robert R. Recker, E. Shane

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We compared microarchitecture and mechanical competence parameters measured by high-resolution peripheral quantitative computed tomography (HR-pQCT) and finite-element analysis of radius and tibia to those measured by histomorphometry, micro-CT, and finite-element analysis of transiliac bone biopsies. Correlations were weak to moderate between parameters measured on biopsies and scans. Introduction: HR-pQCT is a new imaging technique that assesses trabecular and cortical bone microarchitecture of the radius and tibia in vivo. The purpose of this study was to determine the extent to which microarchitectural variables measured by HR-pQCT reflect those measured by the "gold standard," transiliac bone biopsy. Methods: HR-pQCT scans (Xtreme CT, Scanco Medical AG) and iliac crest bone biopsies were performed in 54 subjects (aged 39±10 years). Biopsies were analyzed by 2D quantitative histomorphometry and 3D microcomputed tomography (μCT). Apparent Young's modulus, an estimate of mechanical competence or strength, was determined by micro-finite-element analysis (μFE) of biopsy μCT and HR-pQCT images. Results: The strongest correlations observed were between trabecular parameters (bone volume fraction, number, separation) measured by μCT of biopsies and HR-pQCT of the radius (R 0.365-0.522; P

Original languageEnglish
Pages (from-to)263-273
Number of pages11
JournalOsteoporosis International
Issue number2
Publication statusPublished - Feb 2010


All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism

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