Association analysis of vitamin D-binding protein gene polymorphisms with variations of obesity-related traits in Caucasian nuclear families

H. Jiang, D. H. Xiong, Y. F. Guo, H. Shen, P. Xiao, F. Yang, Y. Chen, F. Zhang, R. R. Recker, H. W. Deng

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Abstract

Background: Vitamin D-binding protein (DBP) gene is well known for its function on glucose and vitamin D metabolism in human populations. Previous studies suggested that the in vivo DBP level may play a role in the etiology of obesity. However, few studies explored the contribution of DBP gene to the variance of obesity phenotypes. Objective: To investigate the relationship of DBP polymorphisms and obesity in Caucasian nuclear families. Design: We genotyped 14 single-nucleotide polymorphisms (SNPs) located in and around the DBP gene in 1873 Caucasian subjects from 405 nuclear families. Three obesity-related quantitative phenotypes were investigated, including body mass index (BMI), fat mass and percentage of fat mass (PFM). Single SNPs and haplotypes (three blocks) were tested by family-based association using the FBAT software. Results: SNP2 (rs17467825) and its corresponding haplotype GAA (frequency 0.270) in block1 showed strongest associations with PFM (P=0.0011 and 0.0023, respectively). In multivariate test significant association was also observed for SNP2 with fat_mass&BMI&PFM (P=0.0098). Subsequent sex-stratified analyses demonstrated nominal association for SNP2 and haplotype GAA with PFM in the female subgroup. Conclusion: Polymorphisms of DBP gene were significantly association with human PFM, especially in female, suggesting the importance of DBP gene in the pathogenesis of human obesity.

Original languageEnglish (US)
Pages (from-to)1319-1324
Number of pages6
JournalInternational Journal of Obesity
Volume31
Issue number8
DOIs
StatePublished - Aug 1 2007

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All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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