Association analysis of vitamin D-binding protein gene polymorphisms with variations of obesity-related traits in Caucasian nuclear families

H. Jiang, D. H. Xiong, Y. F. Guo, H. Shen, P. Xiao, F. Yang, Y. Chen, F. Zhang, Robert R. Recker, H. W. Deng

Research output: Contribution to journalArticle

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Abstract

Background: Vitamin D-binding protein (DBP) gene is well known for its function on glucose and vitamin D metabolism in human populations. Previous studies suggested that the in vivo DBP level may play a role in the etiology of obesity. However, few studies explored the contribution of DBP gene to the variance of obesity phenotypes. Objective: To investigate the relationship of DBP polymorphisms and obesity in Caucasian nuclear families. Design: We genotyped 14 single-nucleotide polymorphisms (SNPs) located in and around the DBP gene in 1873 Caucasian subjects from 405 nuclear families. Three obesity-related quantitative phenotypes were investigated, including body mass index (BMI), fat mass and percentage of fat mass (PFM). Single SNPs and haplotypes (three blocks) were tested by family-based association using the FBAT software. Results: SNP2 (rs17467825) and its corresponding haplotype GAA (frequency 0.270) in block1 showed strongest associations with PFM (P=0.0011 and 0.0023, respectively). In multivariate test significant association was also observed for SNP2 with fat_mass&BMI&PFM (P=0.0098). Subsequent sex-stratified analyses demonstrated nominal association for SNP2 and haplotype GAA with PFM in the female subgroup. Conclusion: Polymorphisms of DBP gene were significantly association with human PFM, especially in female, suggesting the importance of DBP gene in the pathogenesis of human obesity.

Original languageEnglish
Pages (from-to)1319-1324
Number of pages6
JournalInternational Journal of Obesity
Volume31
Issue number8
DOIs
StatePublished - Aug 2007

Fingerprint

vitamin D-binding protein
Vitamin D-Binding Protein
nuclear family
Nuclear Family
obesity
Obesity
Fats
binding proteins
genetic polymorphism
Carrier Proteins
lipids
Genes
Haplotypes
genes
haplotypes
single nucleotide polymorphism
Single Nucleotide Polymorphism
body mass index
Body Mass Index
Phenotype

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Association analysis of vitamin D-binding protein gene polymorphisms with variations of obesity-related traits in Caucasian nuclear families. / Jiang, H.; Xiong, D. H.; Guo, Y. F.; Shen, H.; Xiao, P.; Yang, F.; Chen, Y.; Zhang, F.; Recker, Robert R.; Deng, H. W.

In: International Journal of Obesity, Vol. 31, No. 8, 08.2007, p. 1319-1324.

Research output: Contribution to journalArticle

Jiang, H. ; Xiong, D. H. ; Guo, Y. F. ; Shen, H. ; Xiao, P. ; Yang, F. ; Chen, Y. ; Zhang, F. ; Recker, Robert R. ; Deng, H. W. / Association analysis of vitamin D-binding protein gene polymorphisms with variations of obesity-related traits in Caucasian nuclear families. In: International Journal of Obesity. 2007 ; Vol. 31, No. 8. pp. 1319-1324.
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