Association between Vitamin D receptor polymorphisms and the rate of bone loss in elderly women - Importance of adjusting for dietary and lifestyle factors

P. B. Rapuri, John Christopher G. Gallagher, J. A. Knezetic, H. K. Kinyamu, K. L. Ryschon

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Abstract

The association between the restriction length polymorphisms of the Vitamin D receptor (VDR) gene and the bone mineral density (BMD) or the rate of bone loss is still under debate. In a longitudinal study of untreated postmenopausal elderly women, we evaluated the relationship between the VDR gene polymorphisms (BsmI, TaqI, ApaI, and FokI) and the rate of bone loss over a 3-year period. We also examined the effect of adjustments for dietary and lifestyle factors on these associations. Before adjustments, the rate of femoral neck bone loss was -3.76±1.58% in women with BB genotype and 0.45±0.65% in women with bb genotype, which was not significantly different. Upon adjustment for dietary and lifestyle factors, statistically significant (P=0.03) bone loss was observed at femoral neck in women with BB genotype (-3.66±2.44%) compared to that of bb genotype (2.39±1.32%). Similar results were observed with TaqI genotypes. The rates of bone loss at other skeletal sites were not different between VDR genotypes defined by BsmI and TaqI. VDR gene polymorphisms defined by ApaI and FokI were not related to the rate of bone loss.

Original languageEnglish
Pages (from-to)503-506
Number of pages4
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume89-90
DOIs
StatePublished - May 2004

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Calcitriol Receptors
Polymorphism
Life Style
Bone
Genotype
Bone and Bones
Femur Neck
Genes
Social Adjustment
Bone Density
Longitudinal Studies
Minerals

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Endocrinology

Cite this

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title = "Association between Vitamin D receptor polymorphisms and the rate of bone loss in elderly women - Importance of adjusting for dietary and lifestyle factors",
abstract = "The association between the restriction length polymorphisms of the Vitamin D receptor (VDR) gene and the bone mineral density (BMD) or the rate of bone loss is still under debate. In a longitudinal study of untreated postmenopausal elderly women, we evaluated the relationship between the VDR gene polymorphisms (BsmI, TaqI, ApaI, and FokI) and the rate of bone loss over a 3-year period. We also examined the effect of adjustments for dietary and lifestyle factors on these associations. Before adjustments, the rate of femoral neck bone loss was -3.76±1.58{\%} in women with BB genotype and 0.45±0.65{\%} in women with bb genotype, which was not significantly different. Upon adjustment for dietary and lifestyle factors, statistically significant (P=0.03) bone loss was observed at femoral neck in women with BB genotype (-3.66±2.44{\%}) compared to that of bb genotype (2.39±1.32{\%}). Similar results were observed with TaqI genotypes. The rates of bone loss at other skeletal sites were not different between VDR genotypes defined by BsmI and TaqI. VDR gene polymorphisms defined by ApaI and FokI were not related to the rate of bone loss.",
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AU - Ryschon, K. L.

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