TY - JOUR
T1 - Association of anemia with outcomes of acute heart failure
AU - Halawa, Ahmad
AU - Burton, M. Caroline
AU - Maniaci, Michael J.
AU - Shapiro, Brian P.
AU - Yip, Daniel S.
AU - Hodge, David O.
AU - Vargas, Emily R.
AU - Dawson, Nancy
N1 - Funding Information:
From the Division of Cardiovascular Medicine, University of Missouri, Columbia, Missouri, and the Division of Cardiovascular Diseases and Department of Biomedical Statistics, Division of Hospital Internal Medicine, Mayo Clinic, Jacksonville, Florida. Correspondence to Dr Nancy Dawson, Division of Hospital Internal Medicine, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224. E-mail: Dawson.nancy11@mayo.edu. To purchase a single copy of this article, visit sma.org/smj-home. To purchase larger reprint quantities, please contact Reprintsolutions@wolterskluwer.com. This work was funded by Mayo Clinic Foundation and is copyrighted by the Mayo Foundation for Medical Education and Research. The authors did not report any financial relationships or conflicts of interest. Accepted August 24, 2017. Supplemental digital content is available for this article. Direct URL citations appear in the printed text, and links to the digital files are provided in the HTML text of this article on the journal’s Web site (http://sma.org/smj-home). Copyright © 2018 by The Southern Medical Association 0038-4348/0–2000/111-103 DOI: 10.14423/SMJ.0000000000000767
Publisher Copyright:
Copyright © 2018 by The Southern Medical Association.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Objectives: Anemia is common in patients presenting with acute congestive heart failure (CHF); when hemoglobin (HGB) declines to low levels, it can result in worse outcomes. The aim of this study was to determine a level of HGB on admission or discharge that affects outcomes in patients with CHF and then to evaluate the effect of the low HGB levels on these outcomes. Methods: We conducted a retrospective cohort study of 756 patients admitted with acute CHF during the period January 1, 2011-December 31, 2014. We used multivariable regression analysis to evaluate the relation among HGB levels and three major outcomes: 3-year mortality, 30-day readmission rate, and length of stay (LOS). Results: Compared with patients with HGB ≥10 g/dL, patients with HGB <10 g/dL on discharge from the hospital had higher mortality (3-year survival 46% vs 33%, P = 0.023) and 30-day readmission rates (23% vs 14%; P = 0.008) and increased LOS (4.8 vs 3.2 days, P < 0.001). Patients with admission HGB <10 g/dL had higher mortality rates (3-year survival 45% vs 32%, P = 0.019) and increased LOS (4.5 vs 3.4 days, P = 0.014). A lower admission HGB value was associated with higher 30-day readmission rates, but it was not statistically significant (P = 0.06). Conclusions: An HGB level <10 g/dL on admission or discharge in patients hospitalized with acute CHF is associated with a significantly worse outcome.
AB - Objectives: Anemia is common in patients presenting with acute congestive heart failure (CHF); when hemoglobin (HGB) declines to low levels, it can result in worse outcomes. The aim of this study was to determine a level of HGB on admission or discharge that affects outcomes in patients with CHF and then to evaluate the effect of the low HGB levels on these outcomes. Methods: We conducted a retrospective cohort study of 756 patients admitted with acute CHF during the period January 1, 2011-December 31, 2014. We used multivariable regression analysis to evaluate the relation among HGB levels and three major outcomes: 3-year mortality, 30-day readmission rate, and length of stay (LOS). Results: Compared with patients with HGB ≥10 g/dL, patients with HGB <10 g/dL on discharge from the hospital had higher mortality (3-year survival 46% vs 33%, P = 0.023) and 30-day readmission rates (23% vs 14%; P = 0.008) and increased LOS (4.8 vs 3.2 days, P < 0.001). Patients with admission HGB <10 g/dL had higher mortality rates (3-year survival 45% vs 32%, P = 0.019) and increased LOS (4.5 vs 3.4 days, P = 0.014). A lower admission HGB value was associated with higher 30-day readmission rates, but it was not statistically significant (P = 0.06). Conclusions: An HGB level <10 g/dL on admission or discharge in patients hospitalized with acute CHF is associated with a significantly worse outcome.
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U2 - 10.14423/SMJ.0000000000000767
DO - 10.14423/SMJ.0000000000000767
M3 - Article
C2 - 29394427
AN - SCOPUS:85041486947
VL - 111
SP - 103
EP - 108
JO - Southern Medical Journal
JF - Southern Medical Journal
SN - 0038-4348
IS - 2
ER -