Association of bone dimensions with a parathyroid hormone gene polymorphism in women

G. Gong, M. L. Johnson, M. J. Barger-Lux, R. P. Heaney

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

We have recently shown that bone radiogrammetric dimensions are associated with vitamin D receptor gene polymorphism. Since parathyroid hormone (PTH) plays a central role in maintaining calcium homeostasis and in bone remodeling, we investigated whether bone radiogrammetric dimensions are associated with a PTH gene polymorphism in 91 healthy Caucasian women, who were premenopausal at entry into the study. These women had assessments of bone by radiogrammetry every five years for a median period of 20 years (range 4-27). DNA was extracted from white blood cells. A segment of the PTH gene with a polymorphism at a BstBI restriction site was amplified by polymerase chain reaction. Diameter, cortical thickness and cross-sectional area at standard sites of the metacarpals, radius and femur were measured with radiogrammetry. Higher metacarpal diameter and cross-sectional cortical area, and a slower decrease in radial cortical area with age, were associated with the absence of the BstBI restriction site of the PTH gene. PTH gene polymorphism accounts for about 7-9% of the total variances of bone dimensional variables. These findings suggest that the dimensions of long bones are influenced by allelic variations in the PTH gene or in genes nearby.

Original languageEnglish
Pages (from-to)307-311
Number of pages5
JournalOsteoporosis International
Volume9
Issue number4
DOIs
StatePublished - 1999

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Parathyroid Hormone
Bone and Bones
Genes
Metacarpal Bones
Calcitriol Receptors
Bone Remodeling
Femur
Leukocytes
Homeostasis
Calcium
Polymerase Chain Reaction
DNA

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Association of bone dimensions with a parathyroid hormone gene polymorphism in women. / Gong, G.; Johnson, M. L.; Barger-Lux, M. J.; Heaney, R. P.

In: Osteoporosis International, Vol. 9, No. 4, 1999, p. 307-311.

Research output: Contribution to journalArticle

Gong, G. ; Johnson, M. L. ; Barger-Lux, M. J. ; Heaney, R. P. / Association of bone dimensions with a parathyroid hormone gene polymorphism in women. In: Osteoporosis International. 1999 ; Vol. 9, No. 4. pp. 307-311.
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