Association of MS Pi phenotype with airway hyperresponsiveness

R. G. Townley, J. G. Southard, P. Radford, R. J. Hopp, Againdra K. Bewtra, L. Ford

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Abstract

Asthmatic families (AFs) and normal families (NFs) were studied to determine the relationship between bronchial hyperresponsiveness and α1-antitrypsin protease inhibitor phenotype. We studied IgE levels, skin test scores, and methacholine sensitivity. In both the AF and NF groups, the subjects with the MS phenotype had significantly greater methacholine-induced bronchial hyperresponsiveness sensitivity than the MM and MZ subjects. These findings suggest that the S allele may be associated with bronchial hyperresponsiveness.

Original languageEnglish
Pages (from-to)594-599
Number of pages6
JournalChest
Volume98
Issue number3
Publication statusPublished - 1990

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All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

Townley, R. G., Southard, J. G., Radford, P., Hopp, R. J., Bewtra, A. K., & Ford, L. (1990). Association of MS Pi phenotype with airway hyperresponsiveness. Chest, 98(3), 594-599.