Abstract
Recent research indicates the relative benefits of computerized attention control treatment (ACT) and attention bias modification treatment (ABMT) for posttraumatic stress disorder (PTSD); however, neural changes underlying these therapeutic effects remain unknown. This study examines how these two types of attention training modulate neurological dysfunction in veterans with PTSD. A community sample of 46 combat veterans with PTSD participated in a randomized double-blinded clinical trial of ACT versus ABMT and 32 of those veterans also agreed to undergo resting-state magnetoencephalography (MEG) recordings. Twenty-four veterans completed psychological and MEG assessments at pre- and post-training to evaluate treatment effects. MEG data were imaged using an advanced Bayesian reconstruction method and examined using statistical parametric mapping. In this report, we focus on the neural correlates and the differential treatment effects observed using MEG; the results of the full clinical trial have been described elsewhere. Our results indicated that ACT modulated occipital and ABMT modulated medial temporal activity more strongly than the comparative treatment. PTSD symptoms decreased significantly from pre- to post-test. These initial neurophysiological outcome data suggest that ACT modulates visual pathways, while ABMT modulates threat-processing regions, but that both are associated with normalizing aberrant neural activity in veterans with PTSD.
| Original language | English (US) |
|---|---|
| Journal | Psychiatry Research - Neuroimaging |
| DOIs | |
| State | Accepted/In press - Jan 1 2017 |
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All Science Journal Classification (ASJC) codes
- Neuroscience (miscellaneous)
- Radiology Nuclear Medicine and imaging
- Psychiatry and Mental health
Cite this
Attention training modulates resting-state neurophysiological abnormalities in posttraumatic stress disorder. / Badura Brack, Amy S.; McDermott, Timothy J.; Becker, Katherine M.; Ryan, Tara J.; Khanna, Maya M.; Pine, Daniel S.; Bar-Haim, Yair; Heinrichs-Graham, Elizabeth; Wilson, Tony W.
In: Psychiatry Research - Neuroimaging, 01.01.2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Attention training modulates resting-state neurophysiological abnormalities in posttraumatic stress disorder
AU - Badura Brack, Amy S.
AU - McDermott, Timothy J.
AU - Becker, Katherine M.
AU - Ryan, Tara J.
AU - Khanna, Maya M.
AU - Pine, Daniel S.
AU - Bar-Haim, Yair
AU - Heinrichs-Graham, Elizabeth
AU - Wilson, Tony W.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Recent research indicates the relative benefits of computerized attention control treatment (ACT) and attention bias modification treatment (ABMT) for posttraumatic stress disorder (PTSD); however, neural changes underlying these therapeutic effects remain unknown. This study examines how these two types of attention training modulate neurological dysfunction in veterans with PTSD. A community sample of 46 combat veterans with PTSD participated in a randomized double-blinded clinical trial of ACT versus ABMT and 32 of those veterans also agreed to undergo resting-state magnetoencephalography (MEG) recordings. Twenty-four veterans completed psychological and MEG assessments at pre- and post-training to evaluate treatment effects. MEG data were imaged using an advanced Bayesian reconstruction method and examined using statistical parametric mapping. In this report, we focus on the neural correlates and the differential treatment effects observed using MEG; the results of the full clinical trial have been described elsewhere. Our results indicated that ACT modulated occipital and ABMT modulated medial temporal activity more strongly than the comparative treatment. PTSD symptoms decreased significantly from pre- to post-test. These initial neurophysiological outcome data suggest that ACT modulates visual pathways, while ABMT modulates threat-processing regions, but that both are associated with normalizing aberrant neural activity in veterans with PTSD.
AB - Recent research indicates the relative benefits of computerized attention control treatment (ACT) and attention bias modification treatment (ABMT) for posttraumatic stress disorder (PTSD); however, neural changes underlying these therapeutic effects remain unknown. This study examines how these two types of attention training modulate neurological dysfunction in veterans with PTSD. A community sample of 46 combat veterans with PTSD participated in a randomized double-blinded clinical trial of ACT versus ABMT and 32 of those veterans also agreed to undergo resting-state magnetoencephalography (MEG) recordings. Twenty-four veterans completed psychological and MEG assessments at pre- and post-training to evaluate treatment effects. MEG data were imaged using an advanced Bayesian reconstruction method and examined using statistical parametric mapping. In this report, we focus on the neural correlates and the differential treatment effects observed using MEG; the results of the full clinical trial have been described elsewhere. Our results indicated that ACT modulated occipital and ABMT modulated medial temporal activity more strongly than the comparative treatment. PTSD symptoms decreased significantly from pre- to post-test. These initial neurophysiological outcome data suggest that ACT modulates visual pathways, while ABMT modulates threat-processing regions, but that both are associated with normalizing aberrant neural activity in veterans with PTSD.
UR - http://www.scopus.com/inward/record.url?scp=85034780835&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85034780835&partnerID=8YFLogxK
U2 - 10.1016/j.pscychresns.2017.11.008
DO - 10.1016/j.pscychresns.2017.11.008
M3 - Article
C2 - 29174765
AN - SCOPUS:85034780835
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
SN - 0925-4927
ER -