Attenuation of antigen-induced bronchoconstriction in guinea pigs by a new xanthine derivative (HWA448)

Haruhito Sugiyama, Wu Gang, Virginia A. Bergren, Ryosuke Eda, Dale R. Bergren, Russell J. Hopp, Againdra K. Bewtra, Robert G. Townley

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Abstract

We examined the effect of a new xanthine derivative, HWA448, on antigen-induced bronchoconstriction in actively sensitized guinea pigs. Guinea pigs were sensitized by intraperitoneal injection of bovine serum albumin (BSA) on two occasions, separated by 10 days. Two weeks after the second injection, the animal was placed in a two-chambered whole body plethysmograph and specific airway resistance (SRaw) was monitored for 10 min after an aerosol inhalation of BSA. HWA448 prevented the increase in SRaw after challenge (at 5 and 20 mg/kg i.p.). Aminophylline also prevented the increase in SRaw at 20 mg/kg, but not at a 5-mg/kg dose. The concentration of HWA448, which produced 50% relaxation of the tracheal rings constricted with 0.1 mM of histamine, was 49.9 μM as compared with 18.2 μM in aminophylline. HWA448 has a protective effect on antigen-induced bronchoconstriction in guinea pigs and may be a useful agent in the therapy of bronchial asthma.

Original languageEnglish
Pages (from-to)206-210
Number of pages5
JournalInternational Archives of Allergy and Immunology
Volume96
Issue number3
DOIs
Publication statusPublished - 1991

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All Science Journal Classification (ASJC) codes

  • Immunology
  • Immunology and Allergy

Cite this

Sugiyama, H., Gang, W., Bergren, V. A., Eda, R., Bergren, D. R., Hopp, R. J., ... Townley, R. G. (1991). Attenuation of antigen-induced bronchoconstriction in guinea pigs by a new xanthine derivative (HWA448). International Archives of Allergy and Immunology, 96(3), 206-210. https://doi.org/10.1159/000235496