Abstract
We examined the effect of a new xanthine derivative, HWA448, on antigen-induced bronchoconstriction in actively sensitized guinea pigs. Guinea pigs were sensitized by intraperitoneal injection of bovine serum albumin (BSA) on two occasions, separated by 10 days. Two weeks after the second injection, the animal was placed in a two-chambered whole body plethysmograph and specific airway resistance (SRaw) was monitored for 10 min after an aerosol inhalation of BSA. HWA448 prevented the increase in SRaw after challenge (at 5 and 20 mg/kg i.p.). Aminophylline also prevented the increase in SRaw at 20 mg/kg, but not at a 5-mg/kg dose. The concentration of HWA448, which produced 50% relaxation of the tracheal rings constricted with 0.1 mM of histamine, was 49.9 μM as compared with 18.2 μM in aminophylline. HWA448 has a protective effect on antigen-induced bronchoconstriction in guinea pigs and may be a useful agent in the therapy of bronchial asthma.
| Original language | English |
|---|---|
| Pages (from-to) | 206-210 |
| Number of pages | 5 |
| Journal | International Archives of Allergy and Immunology |
| Volume | 96 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1991 |
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All Science Journal Classification (ASJC) codes
- Immunology
- Immunology and Allergy
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Attenuation of antigen-induced bronchoconstriction in guinea pigs by a new xanthine derivative (HWA448). / Sugiyama, Haruhito; Gang, Wu; Bergren, Virginia A.; Eda, Ryosuke; Bergren, Dale R.; Hopp, Russell J.; Bewtra, Againdra K.; Townley, Robert G.
In: International Archives of Allergy and Immunology, Vol. 96, No. 3, 1991, p. 206-210.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Attenuation of antigen-induced bronchoconstriction in guinea pigs by a new xanthine derivative (HWA448)
AU - Sugiyama, Haruhito
AU - Gang, Wu
AU - Bergren, Virginia A.
AU - Eda, Ryosuke
AU - Bergren, Dale R.
AU - Hopp, Russell J.
AU - Bewtra, Againdra K.
AU - Townley, Robert G.
PY - 1991
Y1 - 1991
N2 - We examined the effect of a new xanthine derivative, HWA448, on antigen-induced bronchoconstriction in actively sensitized guinea pigs. Guinea pigs were sensitized by intraperitoneal injection of bovine serum albumin (BSA) on two occasions, separated by 10 days. Two weeks after the second injection, the animal was placed in a two-chambered whole body plethysmograph and specific airway resistance (SRaw) was monitored for 10 min after an aerosol inhalation of BSA. HWA448 prevented the increase in SRaw after challenge (at 5 and 20 mg/kg i.p.). Aminophylline also prevented the increase in SRaw at 20 mg/kg, but not at a 5-mg/kg dose. The concentration of HWA448, which produced 50% relaxation of the tracheal rings constricted with 0.1 mM of histamine, was 49.9 μM as compared with 18.2 μM in aminophylline. HWA448 has a protective effect on antigen-induced bronchoconstriction in guinea pigs and may be a useful agent in the therapy of bronchial asthma.
AB - We examined the effect of a new xanthine derivative, HWA448, on antigen-induced bronchoconstriction in actively sensitized guinea pigs. Guinea pigs were sensitized by intraperitoneal injection of bovine serum albumin (BSA) on two occasions, separated by 10 days. Two weeks after the second injection, the animal was placed in a two-chambered whole body plethysmograph and specific airway resistance (SRaw) was monitored for 10 min after an aerosol inhalation of BSA. HWA448 prevented the increase in SRaw after challenge (at 5 and 20 mg/kg i.p.). Aminophylline also prevented the increase in SRaw at 20 mg/kg, but not at a 5-mg/kg dose. The concentration of HWA448, which produced 50% relaxation of the tracheal rings constricted with 0.1 mM of histamine, was 49.9 μM as compared with 18.2 μM in aminophylline. HWA448 has a protective effect on antigen-induced bronchoconstriction in guinea pigs and may be a useful agent in the therapy of bronchial asthma.
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U2 - 10.1159/000235496
DO - 10.1159/000235496
M3 - Article
VL - 96
SP - 206
EP - 210
JO - International Archives of Allergy and Immunology
JF - International Archives of Allergy and Immunology
SN - 1018-2438
IS - 3
ER -