Attenuation of human leukocyte adherence to endothelial cell monolayers by tyrosine kinase inhibitors

P. E. McGregor, Devendra K. Agrawal, J. D. Edwards

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Expression of cell adhesion molecules is controlled by various cytokines including interleukin-1 (IL-1) and tumor necrosis factor-α (TNFα), but the underlying mechanisms are not clear. In this study, we investigated the role of tyrosine phosphorylated proteins in the regulation of leukocyte adhesion to endothelial cells. We examined the effect of genistein and herbimycin-A, selective inhibitors of tyrosine kinase, on the adherence of human blood neutrophils, lymphocytes, and monocytes to monolayers of human umbilical vein endothelial cells. Both genistein and herbimycin A significantiy inhibited IL-1 and TNFα-induced upregulation of neutrophils (p

Original languageEnglish
Pages (from-to)359-365
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume198
Issue number1
DOIs
StatePublished - 1994

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Molecular Biology

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