Abstract
Expression of cell adhesion molecules is controlled by various cytokines including interleukin-1 (IL-1) and tumor necrosis factor-α (TNFα), but the underlying mechanisms are not clear. In this study, we investigated the role of tyrosine phosphorylated proteins in the regulation of leukocyte adhesion to endothelial cells. We examined the effect of genistein and herbimycin-A, selective inhibitors of tyrosine kinase, on the adherence of human blood neutrophils, lymphocytes, and monocytes to monolayers of human umbilical vein endothelial cells. Both genistein and herbimycin A significantiy inhibited IL-1 and TNFα-induced upregulation of neutrophils (p
| Original language | English |
|---|---|
| Pages (from-to) | 359-365 |
| Number of pages | 7 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 198 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1994 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
Attenuation of human leukocyte adherence to endothelial cell monolayers by tyrosine kinase inhibitors. / McGregor, P. E.; Agrawal, Devendra K.; Edwards, J. D.
In: Biochemical and Biophysical Research Communications, Vol. 198, No. 1, 1994, p. 359-365.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Attenuation of human leukocyte adherence to endothelial cell monolayers by tyrosine kinase inhibitors
AU - McGregor, P. E.
AU - Agrawal, Devendra K.
AU - Edwards, J. D.
PY - 1994
Y1 - 1994
N2 - Expression of cell adhesion molecules is controlled by various cytokines including interleukin-1 (IL-1) and tumor necrosis factor-α (TNFα), but the underlying mechanisms are not clear. In this study, we investigated the role of tyrosine phosphorylated proteins in the regulation of leukocyte adhesion to endothelial cells. We examined the effect of genistein and herbimycin-A, selective inhibitors of tyrosine kinase, on the adherence of human blood neutrophils, lymphocytes, and monocytes to monolayers of human umbilical vein endothelial cells. Both genistein and herbimycin A significantiy inhibited IL-1 and TNFα-induced upregulation of neutrophils (p
AB - Expression of cell adhesion molecules is controlled by various cytokines including interleukin-1 (IL-1) and tumor necrosis factor-α (TNFα), but the underlying mechanisms are not clear. In this study, we investigated the role of tyrosine phosphorylated proteins in the regulation of leukocyte adhesion to endothelial cells. We examined the effect of genistein and herbimycin-A, selective inhibitors of tyrosine kinase, on the adherence of human blood neutrophils, lymphocytes, and monocytes to monolayers of human umbilical vein endothelial cells. Both genistein and herbimycin A significantiy inhibited IL-1 and TNFα-induced upregulation of neutrophils (p
UR - http://www.scopus.com/inward/record.url?scp=0028234825&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028234825&partnerID=8YFLogxK
U2 - 10.1006/bbrc.1994.1050
DO - 10.1006/bbrc.1994.1050
M3 - Article
VL - 198
SP - 359
EP - 365
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 1
ER -