Attenuation of human leukocyte adherence to endothelial cell monolayers by tyrosine kinase inhibitors

P. E. McGregor; Devendra K. Agrawal; J. D. Edwards

doi:10.1006/bbrc.1994.1050

Attenuation of human leukocyte adherence to endothelial cell monolayers by tyrosine kinase inhibitors

P. E. McGregor, Devendra K. Agrawal, J. D. Edwards

Department of Clinical and Translational Science

Research output: Contribution to journal › Article

48 Scopus citations

Abstract

Expression of cell adhesion molecules is controlled by various cytokines including interleukin-1 (IL-1) and tumor necrosis factor-α (TNFα), but the underlying mechanisms are not clear. In this study, we investigated the role of tyrosine phosphorylated proteins in the regulation of leukocyte adhesion to endothelial cells. We examined the effect of genistein and herbimycin-A, selective inhibitors of tyrosine kinase, on the adherence of human blood neutrophils, lymphocytes, and monocytes to monolayers of human umbilical vein endothelial cells. Both genistein and herbimycin A significantiy inhibited IL-1 and TNFα-induced upregulation of neutrophils (p

Original language	English
Pages (from-to)	359-365
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	198
Issue number	1
DOIs	https://doi.org/10.1006/bbrc.1994.1050
State	Published - 1994

All Science Journal Classification (ASJC) codes

Biochemistry
Biophysics
Molecular Biology

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McGregor, P. E., Agrawal, D. K., & Edwards, J. D. (1994). Attenuation of human leukocyte adherence to endothelial cell monolayers by tyrosine kinase inhibitors. Biochemical and Biophysical Research Communications, 198(1), 359-365. https://doi.org/10.1006/bbrc.1994.1050

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