Attenuation of human leukocyte adherence to endothelial cell monolayers by tyrosine kinase inhibitors

P. E. McGregor, Devendra K. Agrawal, J. D. Edwards

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    48 Scopus citations

    Abstract

    Expression of cell adhesion molecules is controlled by various cytokines including interleukin-1 (IL-1) and tumor necrosis factor-α (TNFα), but the underlying mechanisms are not clear. In this study, we investigated the role of tyrosine phosphorylated proteins in the regulation of leukocyte adhesion to endothelial cells. We examined the effect of genistein and herbimycin-A, selective inhibitors of tyrosine kinase, on the adherence of human blood neutrophils, lymphocytes, and monocytes to monolayers of human umbilical vein endothelial cells. Both genistein and herbimycin A significantiy inhibited IL-1 and TNFα-induced upregulation of neutrophils (p

    Original languageEnglish
    Pages (from-to)359-365
    Number of pages7
    JournalBiochemical and Biophysical Research Communications
    Volume198
    Issue number1
    DOIs
    StatePublished - 1994

    All Science Journal Classification (ASJC) codes

    • Biochemistry
    • Biophysics
    • Molecular Biology

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