Abstract
Available data on metabolic utilization of vitamin D3 indicate a total daily requirement of ∼4000 international units (IU) (100 μg) or twice the current tolerable upper intake level (UL). In young individuals, most of this comes from the skin. However, cutaneous vitamin D3 synthesis declines with age, creating a need for increasing oral intake to maintain optimal serum 25-hydroxyvitamin D [25(OH)D] concentrations. Estimates of the population distribution of serum 25(OH)D values, coupled with available dose-response data, indicate that it would require input of an additional 2600 IU/d (65 μg/d) of oral vitamin D3 to ensure that 97.5% of older women have 25(OH)D values at or above desirable levels. The age-related decline in cutaneous input, taken together with the UL, creates a substantial barrier to the deployment of public health strategies to optimize vitamin D status in the elderly.
| Original language | English |
|---|---|
| Pages (from-to) | 1123-1125 |
| Number of pages | 3 |
| Journal | Journal of Nutrition |
| Volume | 136 |
| Issue number | 4 |
| State | Published - Apr 2006 |
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All Science Journal Classification (ASJC) codes
- Medicine (miscellaneous)
- Food Science
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Barriers to optimizing vitamin D3 intake for the elderly. / Heaney, Robert P.
In: Journal of Nutrition, Vol. 136, No. 4, 04.2006, p. 1123-1125.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Barriers to optimizing vitamin D3 intake for the elderly
AU - Heaney, Robert P.
PY - 2006/4
Y1 - 2006/4
N2 - Available data on metabolic utilization of vitamin D3 indicate a total daily requirement of ∼4000 international units (IU) (100 μg) or twice the current tolerable upper intake level (UL). In young individuals, most of this comes from the skin. However, cutaneous vitamin D3 synthesis declines with age, creating a need for increasing oral intake to maintain optimal serum 25-hydroxyvitamin D [25(OH)D] concentrations. Estimates of the population distribution of serum 25(OH)D values, coupled with available dose-response data, indicate that it would require input of an additional 2600 IU/d (65 μg/d) of oral vitamin D3 to ensure that 97.5% of older women have 25(OH)D values at or above desirable levels. The age-related decline in cutaneous input, taken together with the UL, creates a substantial barrier to the deployment of public health strategies to optimize vitamin D status in the elderly.
AB - Available data on metabolic utilization of vitamin D3 indicate a total daily requirement of ∼4000 international units (IU) (100 μg) or twice the current tolerable upper intake level (UL). In young individuals, most of this comes from the skin. However, cutaneous vitamin D3 synthesis declines with age, creating a need for increasing oral intake to maintain optimal serum 25-hydroxyvitamin D [25(OH)D] concentrations. Estimates of the population distribution of serum 25(OH)D values, coupled with available dose-response data, indicate that it would require input of an additional 2600 IU/d (65 μg/d) of oral vitamin D3 to ensure that 97.5% of older women have 25(OH)D values at or above desirable levels. The age-related decline in cutaneous input, taken together with the UL, creates a substantial barrier to the deployment of public health strategies to optimize vitamin D status in the elderly.
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UR - http://www.scopus.com/inward/citedby.url?scp=33645502291&partnerID=8YFLogxK
M3 - Article
C2 - 16549492
AN - SCOPUS:33645502291
VL - 136
SP - 1123
EP - 1125
JO - Journal of Nutrition
JF - Journal of Nutrition
SN - 0022-3166
IS - 4
ER -