Beyond muscles

The untapped potential of creatine

Lisa A. Riesberg, Stephanie A. Weed, Thomas L. McDonald, Joan Eckerson, Kristen M. Drescher

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Creatine is widely used by both elite and recreational athletes as an ergogenic aid to enhance anaerobic exercise performance. Older individuals also use creatine to prevent sarcopenia and, accordingly, may have therapeutic benefits for muscle wasting diseases. Although the effect of creatine on the musculoskeletal system has been extensively studied, less attention has been paid to its potential effects on other physiological systems. Because there is a significant pool of creatine in the brain, the utility of creatine supplementation has been examined in vitro as well as in vivo in both animal models of neurological disorders and in humans. While the data are preliminary, there is evidence to suggest that individuals with certain neurological conditions may benefit from exogenous creatine supplementation if treatment protocols can be optimized. A small number of studies that have examined the impact of creatine on the immune system have shown an alteration in soluble mediator production and the expression of molecules involved in recognizing infections, specifically toll-like receptors. Future investigations evaluating the total impact of creatine supplementation are required to better understand the benefits and risks of creatine use, particularly since there is increasing evidence that creatine may have a regulatory impact on the immune system.

Original languageEnglish
Pages (from-to)31-42
Number of pages12
JournalInternational Immunopharmacology
Volume37
DOIs
StatePublished - Aug 1 2016

Fingerprint

Creatine
Muscles
Immune System
Sarcopenia
Wasting Syndrome
Musculoskeletal System
Toll-Like Receptors
Clinical Protocols
Nervous System Diseases
Athletes
Animal Models
Exercise

All Science Journal Classification (ASJC) codes

  • Immunology
  • Immunology and Allergy
  • Pharmacology

Cite this

Beyond muscles : The untapped potential of creatine. / Riesberg, Lisa A.; Weed, Stephanie A.; McDonald, Thomas L.; Eckerson, Joan; Drescher, Kristen M.

In: International Immunopharmacology, Vol. 37, 01.08.2016, p. 31-42.

Research output: Contribution to journalArticle

Riesberg, Lisa A. ; Weed, Stephanie A. ; McDonald, Thomas L. ; Eckerson, Joan ; Drescher, Kristen M. / Beyond muscles : The untapped potential of creatine. In: International Immunopharmacology. 2016 ; Vol. 37. pp. 31-42.
@article{02f48ab3758b4f8fb7a450ef385192bf,
title = "Beyond muscles: The untapped potential of creatine",
abstract = "Creatine is widely used by both elite and recreational athletes as an ergogenic aid to enhance anaerobic exercise performance. Older individuals also use creatine to prevent sarcopenia and, accordingly, may have therapeutic benefits for muscle wasting diseases. Although the effect of creatine on the musculoskeletal system has been extensively studied, less attention has been paid to its potential effects on other physiological systems. Because there is a significant pool of creatine in the brain, the utility of creatine supplementation has been examined in vitro as well as in vivo in both animal models of neurological disorders and in humans. While the data are preliminary, there is evidence to suggest that individuals with certain neurological conditions may benefit from exogenous creatine supplementation if treatment protocols can be optimized. A small number of studies that have examined the impact of creatine on the immune system have shown an alteration in soluble mediator production and the expression of molecules involved in recognizing infections, specifically toll-like receptors. Future investigations evaluating the total impact of creatine supplementation are required to better understand the benefits and risks of creatine use, particularly since there is increasing evidence that creatine may have a regulatory impact on the immune system.",
author = "Riesberg, {Lisa A.} and Weed, {Stephanie A.} and McDonald, {Thomas L.} and Joan Eckerson and Drescher, {Kristen M.}",
year = "2016",
month = "8",
day = "1",
doi = "10.1016/j.intimp.2015.12.034",
language = "English",
volume = "37",
pages = "31--42",
journal = "International Immunopharmacology",
issn = "1567-5769",
publisher = "Elsevier",

}

TY - JOUR

T1 - Beyond muscles

T2 - The untapped potential of creatine

AU - Riesberg, Lisa A.

AU - Weed, Stephanie A.

AU - McDonald, Thomas L.

AU - Eckerson, Joan

AU - Drescher, Kristen M.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Creatine is widely used by both elite and recreational athletes as an ergogenic aid to enhance anaerobic exercise performance. Older individuals also use creatine to prevent sarcopenia and, accordingly, may have therapeutic benefits for muscle wasting diseases. Although the effect of creatine on the musculoskeletal system has been extensively studied, less attention has been paid to its potential effects on other physiological systems. Because there is a significant pool of creatine in the brain, the utility of creatine supplementation has been examined in vitro as well as in vivo in both animal models of neurological disorders and in humans. While the data are preliminary, there is evidence to suggest that individuals with certain neurological conditions may benefit from exogenous creatine supplementation if treatment protocols can be optimized. A small number of studies that have examined the impact of creatine on the immune system have shown an alteration in soluble mediator production and the expression of molecules involved in recognizing infections, specifically toll-like receptors. Future investigations evaluating the total impact of creatine supplementation are required to better understand the benefits and risks of creatine use, particularly since there is increasing evidence that creatine may have a regulatory impact on the immune system.

AB - Creatine is widely used by both elite and recreational athletes as an ergogenic aid to enhance anaerobic exercise performance. Older individuals also use creatine to prevent sarcopenia and, accordingly, may have therapeutic benefits for muscle wasting diseases. Although the effect of creatine on the musculoskeletal system has been extensively studied, less attention has been paid to its potential effects on other physiological systems. Because there is a significant pool of creatine in the brain, the utility of creatine supplementation has been examined in vitro as well as in vivo in both animal models of neurological disorders and in humans. While the data are preliminary, there is evidence to suggest that individuals with certain neurological conditions may benefit from exogenous creatine supplementation if treatment protocols can be optimized. A small number of studies that have examined the impact of creatine on the immune system have shown an alteration in soluble mediator production and the expression of molecules involved in recognizing infections, specifically toll-like receptors. Future investigations evaluating the total impact of creatine supplementation are required to better understand the benefits and risks of creatine use, particularly since there is increasing evidence that creatine may have a regulatory impact on the immune system.

UR - http://www.scopus.com/inward/record.url?scp=84953431774&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84953431774&partnerID=8YFLogxK

U2 - 10.1016/j.intimp.2015.12.034

DO - 10.1016/j.intimp.2015.12.034

M3 - Article

VL - 37

SP - 31

EP - 42

JO - International Immunopharmacology

JF - International Immunopharmacology

SN - 1567-5769

ER -