Bicyclic derivatives of hexahydroaporphine

Novel agents that lower intraocular pressure

Shankar L. Saha, Guilin Zhan, Lin Tang, Catherine A. Opere, Edward B. Roche, Carl B. Camras, S. Edet Ohia, Victoria F. Roche

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We have synthesized a number of novel bicyclic hexahydroaporphines containing a phenethylamine moiety for preliminary study as intraocular pressure lowering agents. The target molecules were synthesized in a twelve step process. The final products were secondary or tertiary amines containing either an aromatic methoxy or phenolic substituent These molecules, in hydrochloride salt form, were assayed in doses ranging from 0.1-1.5%. All products and vehicle were administered topically to one eye of normotensive rabbits and intraocular pressure was measured in both eyes for up to six hours. Four of the five compounds examined produced a significant and, in some cases, prolonged, ocular hypotensive response. Secondary and N- methylated tertiary amines were equally effective, as were compounds containing either the 10-methoxy group or free phenol. Studies are currently in progress to optimize potency and identify functional and molecular mechanisms of action.

Original languageEnglish
Pages (from-to)497-505
Number of pages9
JournalJournal of Ocular Pharmacology and Therapeutics
Volume13
Issue number6
StatePublished - Dec 1997

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Intraocular Pressure
Amines
Phenol
Salts
Rabbits

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Ophthalmology
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Bicyclic derivatives of hexahydroaporphine : Novel agents that lower intraocular pressure. / Saha, Shankar L.; Zhan, Guilin; Tang, Lin; Opere, Catherine A.; Roche, Edward B.; Camras, Carl B.; Ohia, S. Edet; Roche, Victoria F.

In: Journal of Ocular Pharmacology and Therapeutics, Vol. 13, No. 6, 12.1997, p. 497-505.

Research output: Contribution to journalArticle

Saha, Shankar L. ; Zhan, Guilin ; Tang, Lin ; Opere, Catherine A. ; Roche, Edward B. ; Camras, Carl B. ; Ohia, S. Edet ; Roche, Victoria F. / Bicyclic derivatives of hexahydroaporphine : Novel agents that lower intraocular pressure. In: Journal of Ocular Pharmacology and Therapeutics. 1997 ; Vol. 13, No. 6. pp. 497-505.
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