Big Lessons from Little Yeast

Budding and Fission Yeast Centrosome Structure, Duplication, and Function

Ann Cavanaugh, Sue L. Jaspersen

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Centrosomes are a functionally conserved feature of eukaryotic cells that play an important role in cell division. The conserved γ-tubulin complex organizes spindle and astral microtubules, which, in turn, separate replicated chromosomes accurately into daughter cells. Like DNA, centrosomes are duplicated once each cell cycle. Although in some cell types it is possible for cell division to occur in the absence of centrosomes, these divisions typically result in defects in chromosome number and stability. In single-celled organisms such as fungi, centrosomes [known as spindle pole bodies (SPBs)] are essential for cell division. SPBs also must be inserted into the membrane because fungi undergo a closed mitosis in which the nuclear envelope (NE) remains intact. This poorly understood process involves events similar or identical to those needed for de novo nuclear pore complex assembly. Here, we review how analysis of fungal SPBs has advanced our understanding of centrosomes and NE events.

Original languageEnglish (US)
Pages (from-to)361-383
Number of pages23
JournalAnnual Review of Genetics
Volume51
DOIs
StatePublished - Nov 27 2017
Externally publishedYes

Fingerprint

Centrosome
Saccharomycetales
Schizosaccharomyces
Spindle Pole Bodies
Yeasts
Cell Division
Nuclear Envelope
Fungi
Nuclear Pore
Chromosomal Instability
Eukaryotic Cells
Tubulin
Mitosis
Microtubules
Cell Cycle
Chromosomes
Membranes
DNA

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Big Lessons from Little Yeast : Budding and Fission Yeast Centrosome Structure, Duplication, and Function. / Cavanaugh, Ann; Jaspersen, Sue L.

In: Annual Review of Genetics, Vol. 51, 27.11.2017, p. 361-383.

Research output: Contribution to journalReview article

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