TY - JOUR
T1 - Big Lessons from Little Yeast
T2 - Budding and Fission Yeast Centrosome Structure, Duplication, and Function
AU - Cavanaugh, Ann M.
AU - Jaspersen, Sue L.
N1 - Funding Information:
We are grateful to Jingjing Chen and Andrew Bestul for help with figures, to Elmar Schiebel, Chip Asbury, and Monica Bettencourt-Dias for sharing results prior to publication, and to Trisha Davis, Mark Winey, Kathy Gould, Sarah Zanders, Michelle Jones, Brian Slaughter, Jay Unruh, Sarah Smith, and members of the Jaspersen lab for comments on the manuscript. The Jaspersen lab is supported by the Stowers Institute for Medical Research and by the National Institute of General Medical Sciences of the National Institutes of Health (NIH) under Award Number R01GM121443. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
Publisher Copyright:
Copyright © 2017 by Annual Reviews. All rights reserved.
PY - 2017/11/27
Y1 - 2017/11/27
N2 - Centrosomes are a functionally conserved feature of eukaryotic cells that play an important role in cell division. The conserved γ-tubulin complex organizes spindle and astral microtubules, which, in turn, separate replicated chromosomes accurately into daughter cells. Like DNA, centrosomes are duplicated once each cell cycle. Although in some cell types it is possible for cell division to occur in the absence of centrosomes, these divisions typically result in defects in chromosome number and stability. In single-celled organisms such as fungi, centrosomes [known as spindle pole bodies (SPBs)] are essential for cell division. SPBs also must be inserted into the membrane because fungi undergo a closed mitosis in which the nuclear envelope (NE) remains intact. This poorly understood process involves events similar or identical to those needed for de novo nuclear pore complex assembly. Here, we review how analysis of fungal SPBs has advanced our understanding of centrosomes and NE events.
AB - Centrosomes are a functionally conserved feature of eukaryotic cells that play an important role in cell division. The conserved γ-tubulin complex organizes spindle and astral microtubules, which, in turn, separate replicated chromosomes accurately into daughter cells. Like DNA, centrosomes are duplicated once each cell cycle. Although in some cell types it is possible for cell division to occur in the absence of centrosomes, these divisions typically result in defects in chromosome number and stability. In single-celled organisms such as fungi, centrosomes [known as spindle pole bodies (SPBs)] are essential for cell division. SPBs also must be inserted into the membrane because fungi undergo a closed mitosis in which the nuclear envelope (NE) remains intact. This poorly understood process involves events similar or identical to those needed for de novo nuclear pore complex assembly. Here, we review how analysis of fungal SPBs has advanced our understanding of centrosomes and NE events.
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U2 - 10.1146/annurev-genet-120116-024733
DO - 10.1146/annurev-genet-120116-024733
M3 - Review article
C2 - 28934593
AN - SCOPUS:85036588911
VL - 51
SP - 361
EP - 383
JO - Annual Review of Genetics
JF - Annual Review of Genetics
SN - 0066-4197
ER -