Biochemical abnormalities of the third component of complement in neonates

Terence L. Zach, Margaret K. Hostetter

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The third component of complement, C3, is of central importance as an opsonin in the nonimmune host. Although gestational deficiencies in C3 levels are well recognized in neonates, defects in complement-mediated functions have not in every case correlated with low levels of complement proteins. Because opsonic functions of C3 are mediated through a reactive thiolester bond, we hypothesized that a biochemical dysfunction at this active site could explain the newborn’s predisposition to infection, even with relatively normal C3 levels. We therefore examined the biochemical integrity of the C3 thiolester in an assay independent of all other complement proteins. As measured by ELISA, mean C3 levels from 44 neonates (24-43 wk) were significantly lower in infants

Original languageEnglish
Pages (from-to)116-120
Number of pages5
JournalPediatric Research
Volume26
Issue number2
StatePublished - 1989
Externally publishedYes

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Newborn Infant
Complement System Proteins
Opsonin Proteins
Complement C3
Catalytic Domain
Enzyme-Linked Immunosorbent Assay
Infection

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Biochemical abnormalities of the third component of complement in neonates. / Zach, Terence L.; Hostetter, Margaret K.

In: Pediatric Research, Vol. 26, No. 2, 1989, p. 116-120.

Research output: Contribution to journalArticle

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