Abstract
Background: The mechanism by which polymorphisms in the anti-aging protein klotho lead to increased disease risk is unknown. Results: In vitro, klotho-VS decreases homodimerization and increases heterodimerization with and activation of FGFR1c. Conclusion: Altered dimerization explains klotho-VS association with increased disease risk. Significance: Understanding how the VS variant leads to changes in klotho function will elucidate the role klotho plays in disease and lifespan.
Original language | English (US) |
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Pages (from-to) | 36302-36311 |
Number of pages | 10 |
Journal | Journal of Biological Chemistry |
Volume | 288 |
Issue number | 51 |
DOIs | |
State | Published - Dec 20 2013 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Biology
- Cell Biology