Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk

Tracey B.Tucker Zhou; Gwendalyn D. King; Ci Di Chen; Carmela R. Abraham

doi:10.1074/jbc.M113.490052

Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk

Tracey B.Tucker Zhou, Gwendalyn D. King, Ci Di Chen, Carmela R. Abraham

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Background: The mechanism by which polymorphisms in the anti-aging protein klotho lead to increased disease risk is unknown. Results: In vitro, klotho-VS decreases homodimerization and increases heterodimerization with and activation of FGFR1c. Conclusion: Altered dimerization explains klotho-VS association with increased disease risk. Significance: Understanding how the VS variant leads to changes in klotho function will elucidate the role klotho plays in disease and lifespan.

Original language	English (US)
Pages (from-to)	36302-36311
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	288
Issue number	51
DOIs	https://doi.org/10.1074/jbc.M113.490052
State	Published - Dec 20 2013
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.490052

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title = "Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk",

abstract = "Background: The mechanism by which polymorphisms in the anti-aging protein klotho lead to increased disease risk is unknown. Results: In vitro, klotho-VS decreases homodimerization and increases heterodimerization with and activation of FGFR1c. Conclusion: Altered dimerization explains klotho-VS association with increased disease risk. Significance: Understanding how the VS variant leads to changes in klotho function will elucidate the role klotho plays in disease and lifespan.",

author = "Zhou, {Tracey B.Tucker} and King, {Gwendalyn D.} and Chen, {Ci Di} and Abraham, {Carmela R.}",

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T1 - Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk

AU - Zhou, Tracey B.Tucker

AU - King, Gwendalyn D.

AU - Chen, Ci Di

AU - Abraham, Carmela R.

PY - 2013/12/20

Y1 - 2013/12/20

N2 - Background: The mechanism by which polymorphisms in the anti-aging protein klotho lead to increased disease risk is unknown. Results: In vitro, klotho-VS decreases homodimerization and increases heterodimerization with and activation of FGFR1c. Conclusion: Altered dimerization explains klotho-VS association with increased disease risk. Significance: Understanding how the VS variant leads to changes in klotho function will elucidate the role klotho plays in disease and lifespan.

AB - Background: The mechanism by which polymorphisms in the anti-aging protein klotho lead to increased disease risk is unknown. Results: In vitro, klotho-VS decreases homodimerization and increases heterodimerization with and activation of FGFR1c. Conclusion: Altered dimerization explains klotho-VS association with increased disease risk. Significance: Understanding how the VS variant leads to changes in klotho function will elucidate the role klotho plays in disease and lifespan.

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Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk

Abstract

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