Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk

Tracey B.Tucker Zhou, Gwendalyn D. King, Ci Di Chen, Carmela R. Abraham

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Background: The mechanism by which polymorphisms in the anti-aging protein klotho lead to increased disease risk is unknown. Results: In vitro, klotho-VS decreases homodimerization and increases heterodimerization with and activation of FGFR1c. Conclusion: Altered dimerization explains klotho-VS association with increased disease risk. Significance: Understanding how the VS variant leads to changes in klotho function will elucidate the role klotho plays in disease and lifespan.

Original languageEnglish (US)
Pages (from-to)36302-36311
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number51
DOIs
StatePublished - Dec 20 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint

Dive into the research topics of 'Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk'. Together they form a unique fingerprint.

Cite this