Abstract
Ovarian cancer has been increasing in frequency during the past several decades, particularly in Western industrialized nations. It has the ignominious distinction of being the major cause of death from genitourinary cancer in women in the United States. A small but significant fraction of patients with ovarian cancer have family histories that are compatible with a primary genetic factor. The hereditary variant is heterogeneous but these pedigrees reveal a high predictability of cancer. Therefore, families that are prone to ovarian cancer merit the highest priority for biomarker investigations. When considering the generally poor surveillance measures available to us for detecting ovarian cancer sufficiently early to improve prognosis, the search for biomarkers of high sensitivity and specificity assumes major significance. In turn, such biomarkers may shed light on the etiology and pathogenesis of ovarian cancer in the general population and more importantly provide mechanisms for early detection and prevention of death from this tumor.
| Original language | English |
|---|---|
| Pages (from-to) | 129-134 |
| Number of pages | 6 |
| Journal | Cancer Detection and Prevention |
| Volume | 8 |
| Issue number | 1-2 |
| State | Published - 1985 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Cancer Research
- Oncology
Cite this
Biomarker studies in hereditary ovarian carcinoma. / Lynch, Henry T.; Schuelke, G. S.; Lynch, J. F.
In: Cancer Detection and Prevention, Vol. 8, No. 1-2, 1985, p. 129-134.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Biomarker studies in hereditary ovarian carcinoma.
AU - Lynch, Henry T.
AU - Schuelke, G. S.
AU - Lynch, J. F.
PY - 1985
Y1 - 1985
N2 - Ovarian cancer has been increasing in frequency during the past several decades, particularly in Western industrialized nations. It has the ignominious distinction of being the major cause of death from genitourinary cancer in women in the United States. A small but significant fraction of patients with ovarian cancer have family histories that are compatible with a primary genetic factor. The hereditary variant is heterogeneous but these pedigrees reveal a high predictability of cancer. Therefore, families that are prone to ovarian cancer merit the highest priority for biomarker investigations. When considering the generally poor surveillance measures available to us for detecting ovarian cancer sufficiently early to improve prognosis, the search for biomarkers of high sensitivity and specificity assumes major significance. In turn, such biomarkers may shed light on the etiology and pathogenesis of ovarian cancer in the general population and more importantly provide mechanisms for early detection and prevention of death from this tumor.
AB - Ovarian cancer has been increasing in frequency during the past several decades, particularly in Western industrialized nations. It has the ignominious distinction of being the major cause of death from genitourinary cancer in women in the United States. A small but significant fraction of patients with ovarian cancer have family histories that are compatible with a primary genetic factor. The hereditary variant is heterogeneous but these pedigrees reveal a high predictability of cancer. Therefore, families that are prone to ovarian cancer merit the highest priority for biomarker investigations. When considering the generally poor surveillance measures available to us for detecting ovarian cancer sufficiently early to improve prognosis, the search for biomarkers of high sensitivity and specificity assumes major significance. In turn, such biomarkers may shed light on the etiology and pathogenesis of ovarian cancer in the general population and more importantly provide mechanisms for early detection and prevention of death from this tumor.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022286181&partnerID=8YFLogxK
M3 - Article
VL - 8
SP - 129
EP - 134
JO - Cancer Epidemiology
JF - Cancer Epidemiology
SN - 1877-7821
IS - 1-2
ER -