Biomarker studies in hereditary ovarian carcinoma.

Henry T. Lynch, G. S. Schuelke, J. F. Lynch

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Ovarian cancer has been increasing in frequency during the past several decades, particularly in Western industrialized nations. It has the ignominious distinction of being the major cause of death from genitourinary cancer in women in the United States. A small but significant fraction of patients with ovarian cancer have family histories that are compatible with a primary genetic factor. The hereditary variant is heterogeneous but these pedigrees reveal a high predictability of cancer. Therefore, families that are prone to ovarian cancer merit the highest priority for biomarker investigations. When considering the generally poor surveillance measures available to us for detecting ovarian cancer sufficiently early to improve prognosis, the search for biomarkers of high sensitivity and specificity assumes major significance. In turn, such biomarkers may shed light on the etiology and pathogenesis of ovarian cancer in the general population and more importantly provide mechanisms for early detection and prevention of death from this tumor.

Original languageEnglish
Pages (from-to)129-134
Number of pages6
JournalCancer Detection and Prevention
Volume8
Issue number1-2
StatePublished - 1985
Externally publishedYes

Fingerprint

Ovarian Neoplasms
Biomarkers
Carcinoma
Urogenital Neoplasms
Pedigree
Developed Countries
Cause of Death
Neoplasms
Sensitivity and Specificity
Population

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Lynch, H. T., Schuelke, G. S., & Lynch, J. F. (1985). Biomarker studies in hereditary ovarian carcinoma. Cancer Detection and Prevention, 8(1-2), 129-134.

Biomarker studies in hereditary ovarian carcinoma. / Lynch, Henry T.; Schuelke, G. S.; Lynch, J. F.

In: Cancer Detection and Prevention, Vol. 8, No. 1-2, 1985, p. 129-134.

Research output: Contribution to journalArticle

Lynch, HT, Schuelke, GS & Lynch, JF 1985, 'Biomarker studies in hereditary ovarian carcinoma.', Cancer Detection and Prevention, vol. 8, no. 1-2, pp. 129-134.
Lynch, Henry T. ; Schuelke, G. S. ; Lynch, J. F. / Biomarker studies in hereditary ovarian carcinoma. In: Cancer Detection and Prevention. 1985 ; Vol. 8, No. 1-2. pp. 129-134.
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