Abstract
Five new vinylchlorine-containing metabolites, the lipoamides janthielamide A and kimbeamides A-C and the ketide-extended pyranone kimbelactone A, have been isolated from collections of marine cyanobacteria made in Curaçao and Papua New Guinea. Both janthielamide A and kimbeamide A exhibited moderate sodium channel blocking activity in murine Neuro-2a cells. Consistent with this activity, janthielamide A was also found to antagonize veratridine-induced sodium influx in murine cerebrocortical neurons. These lipoamides represent the newest additions to a relatively rare family of marine cyanobacterial-derived lipoamides and a new structural class of compounds exhibiting neuromodulatory activities from marine cyanobacteria.
Original language | English (US) |
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Pages (from-to) | 4198-4208 |
Number of pages | 11 |
Journal | Journal of Organic Chemistry |
Volume | 77 |
Issue number | 9 |
DOIs | |
State | Published - May 4 2012 |
All Science Journal Classification (ASJC) codes
- Organic Chemistry