Bisphosphonate effects and the bone remodeling transient

Robert P. Heaney, A. John Yates, Arthur C. Santora

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Published randomized clinical trial data for alendronate, given at a dose of 10 mg/day, were fitted by a computer algorithm to the currently accepted model of the bone remodeling process. The purpose was to determine how much of the reported improvement in lumbar spine bone density could be attributed to the inevitable remodeling transient and how much might represent positive bone balance. Very good fits to the clinical data were easily obtained, indicating the general validity of current syntheses of bone remodeling biology. The best fit was provided by simulations produced by combinations of 36-38% suppression of remodeling activation and positive remodeling balance ranging from 1.1 to 1.4% per year. Whole body bone biomarker changes would have suggested both a slightly greater degree of suppression and a higher baseline level of remodeling than could be provided by any of the simulations if they were to fit the clinical data. Either regional skeletal heterogeneity or lack of a one-to-one quantitative relationship between remodeling changes and biomarker changes may explain the discrepancies between the two approaches.

Original languageEnglish
Pages (from-to)1143-1151
Number of pages9
JournalJournal of Bone and Mineral Research
Volume12
Issue number8
DOIs
StatePublished - Aug 1997

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Bone Remodeling
Diphosphonates
Biomarkers
Bone and Bones
Alendronate
Bone Density
Spine
Randomized Controlled Trials

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Bisphosphonate effects and the bone remodeling transient. / Heaney, Robert P.; Yates, A. John; Santora, Arthur C.

In: Journal of Bone and Mineral Research, Vol. 12, No. 8, 08.1997, p. 1143-1151.

Research output: Contribution to journalArticle

Heaney, Robert P. ; Yates, A. John ; Santora, Arthur C. / Bisphosphonate effects and the bone remodeling transient. In: Journal of Bone and Mineral Research. 1997 ; Vol. 12, No. 8. pp. 1143-1151.
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