Bivariate genome linkage analysis suggests pleiotropic effects on chromosomes 20p and 3p for body fat mass and lean mass

Jian Zhao, Peng Xiao, Yan Guo, Yong Jun Liu, Yu Fang Pei, Tie Lin Yang, Feng Pan, Yuan Chen, Hui Shen, Lan Juan Zhao, Christopher J. Papasian, Betty M. Drees, James J. Hamilton, Hong Yi Deng, Robert R. Recker, Hong Wen Deng

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Total body fat mass (TBFM) and total body lean mass (TBLM) are the major components of the human body. Although these highly correlated phenotypic traits are frequently used to characterize obesity, the specific shared genetic factors that influence both traits remain largely unknown. Our study was aimed at identifying common quantitative trait loci (QTLs) contributing to both TBFM and TBLM. We performed a whole genome-linkage scan study in a large sample of 3255 subjects from 420 Caucasian pedigrees. Bivariate linkage analysis was carried out in both the entire sample and gender-specific subsamples. Several potentially important genomic regions that may harbour QTLs important for TBFM and TBLM were identified. For example, 20p12-11 achieved a LOD score of 2.04 in the entire sample and, in the male subsample, two genomic regions, 20p12 (LOD=2.08) and 3p26-25 (LOD=1.92), showed suggestive linkage. In addition, two-point linkage analyses for chromosome X showed suggestive linkages on Xp22 in the entire sample (LOD=2.14) and signi.cant linkage on Xp22 in the female subsample (LOD=3.05). Complete pleiotropy was suggested for 20p12 and 3p26-25 in males. Our results suggest that QTLs on chromosomes 20p12, 3p26-25 and Xp22 may jointly in.uence TBFM and TBLM. Further fine mapping and gene identification studies for these pleiotropic effects are needed.

Original languageEnglish
Pages (from-to)259-268
Number of pages10
JournalGenetical Research
Volume90
Issue number3
DOIs
StatePublished - Jun 2008

Fingerprint

Adipose Tissue
Quantitative Trait Loci
Chromosomes
Genome
Chromosome Mapping
X Chromosome
Pedigree
Human Body
Obesity

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Bivariate genome linkage analysis suggests pleiotropic effects on chromosomes 20p and 3p for body fat mass and lean mass. / Zhao, Jian; Xiao, Peng; Guo, Yan; Liu, Yong Jun; Pei, Yu Fang; Yang, Tie Lin; Pan, Feng; Chen, Yuan; Shen, Hui; Zhao, Lan Juan; Papasian, Christopher J.; Drees, Betty M.; Hamilton, James J.; Deng, Hong Yi; Recker, Robert R.; Deng, Hong Wen.

In: Genetical Research, Vol. 90, No. 3, 06.2008, p. 259-268.

Research output: Contribution to journalArticle

Zhao, J, Xiao, P, Guo, Y, Liu, YJ, Pei, YF, Yang, TL, Pan, F, Chen, Y, Shen, H, Zhao, LJ, Papasian, CJ, Drees, BM, Hamilton, JJ, Deng, HY, Recker, RR & Deng, HW 2008, 'Bivariate genome linkage analysis suggests pleiotropic effects on chromosomes 20p and 3p for body fat mass and lean mass', Genetical Research, vol. 90, no. 3, pp. 259-268. https://doi.org/10.1017/S0016672308009257
Zhao, Jian ; Xiao, Peng ; Guo, Yan ; Liu, Yong Jun ; Pei, Yu Fang ; Yang, Tie Lin ; Pan, Feng ; Chen, Yuan ; Shen, Hui ; Zhao, Lan Juan ; Papasian, Christopher J. ; Drees, Betty M. ; Hamilton, James J. ; Deng, Hong Yi ; Recker, Robert R. ; Deng, Hong Wen. / Bivariate genome linkage analysis suggests pleiotropic effects on chromosomes 20p and 3p for body fat mass and lean mass. In: Genetical Research. 2008 ; Vol. 90, No. 3. pp. 259-268.
@article{2e66cae286d1446f8147164eeb2270ad,
title = "Bivariate genome linkage analysis suggests pleiotropic effects on chromosomes 20p and 3p for body fat mass and lean mass",
abstract = "Total body fat mass (TBFM) and total body lean mass (TBLM) are the major components of the human body. Although these highly correlated phenotypic traits are frequently used to characterize obesity, the specific shared genetic factors that influence both traits remain largely unknown. Our study was aimed at identifying common quantitative trait loci (QTLs) contributing to both TBFM and TBLM. We performed a whole genome-linkage scan study in a large sample of 3255 subjects from 420 Caucasian pedigrees. Bivariate linkage analysis was carried out in both the entire sample and gender-specific subsamples. Several potentially important genomic regions that may harbour QTLs important for TBFM and TBLM were identified. For example, 20p12-11 achieved a LOD score of 2.04 in the entire sample and, in the male subsample, two genomic regions, 20p12 (LOD=2.08) and 3p26-25 (LOD=1.92), showed suggestive linkage. In addition, two-point linkage analyses for chromosome X showed suggestive linkages on Xp22 in the entire sample (LOD=2.14) and signi.cant linkage on Xp22 in the female subsample (LOD=3.05). Complete pleiotropy was suggested for 20p12 and 3p26-25 in males. Our results suggest that QTLs on chromosomes 20p12, 3p26-25 and Xp22 may jointly in.uence TBFM and TBLM. Further fine mapping and gene identification studies for these pleiotropic effects are needed.",
author = "Jian Zhao and Peng Xiao and Yan Guo and Liu, {Yong Jun} and Pei, {Yu Fang} and Yang, {Tie Lin} and Feng Pan and Yuan Chen and Hui Shen and Zhao, {Lan Juan} and Papasian, {Christopher J.} and Drees, {Betty M.} and Hamilton, {James J.} and Deng, {Hong Yi} and Recker, {Robert R.} and Deng, {Hong Wen}",
year = "2008",
month = "6",
doi = "10.1017/S0016672308009257",
language = "English",
volume = "90",
pages = "259--268",
journal = "Genetical Research",
issn = "0016-6723",
publisher = "Cambridge University Press",
number = "3",

}

TY - JOUR

T1 - Bivariate genome linkage analysis suggests pleiotropic effects on chromosomes 20p and 3p for body fat mass and lean mass

AU - Zhao, Jian

AU - Xiao, Peng

AU - Guo, Yan

AU - Liu, Yong Jun

AU - Pei, Yu Fang

AU - Yang, Tie Lin

AU - Pan, Feng

AU - Chen, Yuan

AU - Shen, Hui

AU - Zhao, Lan Juan

AU - Papasian, Christopher J.

AU - Drees, Betty M.

AU - Hamilton, James J.

AU - Deng, Hong Yi

AU - Recker, Robert R.

AU - Deng, Hong Wen

PY - 2008/6

Y1 - 2008/6

N2 - Total body fat mass (TBFM) and total body lean mass (TBLM) are the major components of the human body. Although these highly correlated phenotypic traits are frequently used to characterize obesity, the specific shared genetic factors that influence both traits remain largely unknown. Our study was aimed at identifying common quantitative trait loci (QTLs) contributing to both TBFM and TBLM. We performed a whole genome-linkage scan study in a large sample of 3255 subjects from 420 Caucasian pedigrees. Bivariate linkage analysis was carried out in both the entire sample and gender-specific subsamples. Several potentially important genomic regions that may harbour QTLs important for TBFM and TBLM were identified. For example, 20p12-11 achieved a LOD score of 2.04 in the entire sample and, in the male subsample, two genomic regions, 20p12 (LOD=2.08) and 3p26-25 (LOD=1.92), showed suggestive linkage. In addition, two-point linkage analyses for chromosome X showed suggestive linkages on Xp22 in the entire sample (LOD=2.14) and signi.cant linkage on Xp22 in the female subsample (LOD=3.05). Complete pleiotropy was suggested for 20p12 and 3p26-25 in males. Our results suggest that QTLs on chromosomes 20p12, 3p26-25 and Xp22 may jointly in.uence TBFM and TBLM. Further fine mapping and gene identification studies for these pleiotropic effects are needed.

AB - Total body fat mass (TBFM) and total body lean mass (TBLM) are the major components of the human body. Although these highly correlated phenotypic traits are frequently used to characterize obesity, the specific shared genetic factors that influence both traits remain largely unknown. Our study was aimed at identifying common quantitative trait loci (QTLs) contributing to both TBFM and TBLM. We performed a whole genome-linkage scan study in a large sample of 3255 subjects from 420 Caucasian pedigrees. Bivariate linkage analysis was carried out in both the entire sample and gender-specific subsamples. Several potentially important genomic regions that may harbour QTLs important for TBFM and TBLM were identified. For example, 20p12-11 achieved a LOD score of 2.04 in the entire sample and, in the male subsample, two genomic regions, 20p12 (LOD=2.08) and 3p26-25 (LOD=1.92), showed suggestive linkage. In addition, two-point linkage analyses for chromosome X showed suggestive linkages on Xp22 in the entire sample (LOD=2.14) and signi.cant linkage on Xp22 in the female subsample (LOD=3.05). Complete pleiotropy was suggested for 20p12 and 3p26-25 in males. Our results suggest that QTLs on chromosomes 20p12, 3p26-25 and Xp22 may jointly in.uence TBFM and TBLM. Further fine mapping and gene identification studies for these pleiotropic effects are needed.

UR - http://www.scopus.com/inward/record.url?scp=47149083644&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=47149083644&partnerID=8YFLogxK

U2 - 10.1017/S0016672308009257

DO - 10.1017/S0016672308009257

M3 - Article

VL - 90

SP - 259

EP - 268

JO - Genetical Research

JF - Genetical Research

SN - 0016-6723

IS - 3

ER -