bla KPC RNA expression correlates with two transcriptional start sites but not always with gene copy number in four genera of gram-negative pathogens

Amanda L. Roth, Philip M. Kurpiel, Philip D. Lister, Nancy D. Hanson

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Klebsiella pneumoniae carbapenemase (KPC)-producing organisms are therapeutically and diagnostically challenging. It is possible that bla KPC gene expression plays a role in the variability observed in clinical susceptibility testing. bla KPC transformants together with 10 clinical isolates representing four genera were evaluated for bla KPC copy number and gene expression and correlated with β-lactam MIC data. The data suggest that mechanisms other than gene copy number and expression of bla KPC contribute to variability in susceptibility when testing KPC-producing isolates.

Original languageEnglish
Pages (from-to)3936-3938
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume55
Issue number8
DOIs
StatePublished - Aug 2011

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Gene Dosage
Klebsiella pneumoniae
RNA
Gene Expression
Lactams
carbapenemase

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

bla KPC RNA expression correlates with two transcriptional start sites but not always with gene copy number in four genera of gram-negative pathogens. / Roth, Amanda L.; Kurpiel, Philip M.; Lister, Philip D.; Hanson, Nancy D.

In: Antimicrobial Agents and Chemotherapy, Vol. 55, No. 8, 08.2011, p. 3936-3938.

Research output: Contribution to journalArticle

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