Klebsiella pneumoniae carbapenemase (KPC)-producing organisms are therapeutically and diagnostically challenging. It is possible that bla KPC gene expression plays a role in the variability observed in clinical susceptibility testing. bla KPC transformants together with 10 clinical isolates representing four genera were evaluated for bla KPC copy number and gene expression and correlated with β-lactam MIC data. The data suggest that mechanisms other than gene copy number and expression of bla KPC contribute to variability in susceptibility when testing KPC-producing isolates.
All Science Journal Classification (ASJC) codes
- Pharmacology (medical)
- Infectious Diseases