bla KPC RNA expression correlates with two transcriptional start sites but not always with gene copy number in four genera of gram-negative pathogens

Amanda L. Roth; Philip M. Kurpiel; Philip D. Lister; Nancy D. Hanson

doi:10.1128/AAC.01509-10

bla _KPC RNA expression correlates with two transcriptional start sites but not always with gene copy number in four genera of gram-negative pathogens

Amanda L. Roth, Philip M. Kurpiel, Philip D. Lister, Nancy D. Hanson

Department of Medical Microbiology and Immunology

Research output: Contribution to journal › Article

17 Scopus citations

Abstract

Klebsiella pneumoniae carbapenemase (KPC)-producing organisms are therapeutically and diagnostically challenging. It is possible that bla _KPC gene expression plays a role in the variability observed in clinical susceptibility testing. bla _KPC transformants together with 10 clinical isolates representing four genera were evaluated for bla _KPC copy number and gene expression and correlated with β-lactam MIC data. The data suggest that mechanisms other than gene copy number and expression of bla _KPC contribute to variability in susceptibility when testing KPC-producing isolates.

Original language	English (US)
Pages (from-to)	3936-3938
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	55
Issue number	8
DOIs	https://doi.org/10.1128/AAC.01509-10
State	Published - Aug 2011

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Roth, A. L., Kurpiel, P. M., Lister, P. D., & Hanson, N. D. (2011). bla _KPC RNA expression correlates with two transcriptional start sites but not always with gene copy number in four genera of gram-negative pathogens. Antimicrobial agents and chemotherapy, 55(8), 3936-3938. https://doi.org/10.1128/AAC.01509-10

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