Blood pressure and cardiovascular disease risk in the Veterans Affairs Diabetes Trial

Robert J. Anderson, Gideon D. Bahn, Thomas E. Moritz, Derrick Kaufman, Carlos Abraira, William Duckworth

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

OBJECTIVE - Blood pressure ranges associated with cardiovascular disease (CVD) events in advanced type 2 diabetes are not clear. Our objective was to determine whether baseline and follow-up (On-Study) systolic blood pressure (SBP), diastolic blood pressure (DBP), and SBP combined with DBP predict CVD events in the Veterans Affairs Diabetes Trial (VADT). RESEARCH DESIGN AND METHODS - Participants in the VADT (n = 1,791) with hypertension received stepped treatment to maintain blood pressure below the target of 130/80 mmHg in standard and intensive glycemic treatment groups. Blood pressure levels of all subjects at baseline and On-Study were analyzed to detect associations with CVD risk. The primary outcome was the time from randomization to the first occurrence of myocardial infarction, stroke, congestive heart failure, surgery for vascular disease, inoperable coronary disease, amputation for ischemic gangrene, or CVD death. RESULTS - Separated SBP ≥140 mmHg had significant risk at baseline (hazards ratio [HR] 1.508, P

Original languageEnglish (US)
Pages (from-to)34-38
Number of pages5
JournalDiabetes care
Volume34
Issue number1
DOIs
StatePublished - Jan 1 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

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    Anderson, R. J., Bahn, G. D., Moritz, T. E., Kaufman, D., Abraira, C., & Duckworth, W. (2011). Blood pressure and cardiovascular disease risk in the Veterans Affairs Diabetes Trial. Diabetes care, 34(1), 34-38. https://doi.org/10.2337/dc10-1420