Bone density, geometry, microstructure, and stiffness

Relationships between peripheral and central skeletal sites assessed by DXA, HR-pQCT, and cQCT in premenopausal women

X. Sherry Liu, Adi Cohen, Elizabeth Shane, Perry T. Yin, Emily M. Stein, Halley Rogers, Shannon L. Kokolus, Donald J. McMahon, Joan M. Lappe, Robert R. Recker, Thomas Lang, X. Edward Guo

Research output: Contribution to journalArticle

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Abstract

High-resolution peripheral quantitative computed tomography (HR-pQCT) is a new in vivo imaging technique for assessing 3D microstructure of cortical and trabecular bone at the distal radius and tibia. No studies have investigated the extent to which measurements of the peripheral skeleton by HR-pQCT reflect those of the spine and hip, where the most serious fractures occur. To address this research question, we performed dual-energy X-ray absorptiometry (DXA), central QCT (cQCT), HR-pQCT, and image-based finite-element analyses on 69 premenopausal women to evaluate relationships among cortical and trabecular bone density, geometry, microstructure, and stiffness of the lumbar spine, proximal femur, distal radius, and distal tibia. Significant correlations were found between the stiffness of the two peripheral sites (r=0.86), two central sites (r=0.49), and, between the peripheral and central skeletal sites (r=0.56-0.70). These associations were explained in part by significant correlations in areal bone mineral density (aBMD), volumetric bone mineral density (vBMD), and cross-sectional area (CSA) between the multiple skeletal sites. For the prediction of proximal femoral stiffness, vBMD (r=0.75) and stiffness (r=0.69) of the distal tibia by HR-pQCT were comparable with direct measurements of the proximal femur: aBMD of the hip by DXA (r=0.70) and vBMD of the hip by cQCT (r=0.64). For the prediction of vertebral stiffness, trabecular vBMD (r=0.58) and stiffness (r=0.70) of distal radius by HR-pQCT were comparable with direct measurements of lumbar spine: aBMD by DXA (r=0.78) and vBMD by cQCT (r=0.67). Our results suggest that bone density and microstructural and mechanical properties measured by HR-pQCT of the distal radius and tibia reflect the mechanical competence of the central skeleton.

Original languageEnglish
Pages (from-to)2229-2238
Number of pages10
JournalJournal of Bone and Mineral Research
Volume25
Issue number10
DOIs
StatePublished - Oct 2010

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Photon Absorptiometry
Bone Density
Tomography
Tibia
Hip
Spine
Skeleton
Femur
Finite Element Analysis
Thigh
Mental Competency

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism

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Bone density, geometry, microstructure, and stiffness : Relationships between peripheral and central skeletal sites assessed by DXA, HR-pQCT, and cQCT in premenopausal women. / Liu, X. Sherry; Cohen, Adi; Shane, Elizabeth; Yin, Perry T.; Stein, Emily M.; Rogers, Halley; Kokolus, Shannon L.; McMahon, Donald J.; Lappe, Joan M.; Recker, Robert R.; Lang, Thomas; Guo, X. Edward.

In: Journal of Bone and Mineral Research, Vol. 25, No. 10, 10.2010, p. 2229-2238.

Research output: Contribution to journalArticle

Liu, X. Sherry ; Cohen, Adi ; Shane, Elizabeth ; Yin, Perry T. ; Stein, Emily M. ; Rogers, Halley ; Kokolus, Shannon L. ; McMahon, Donald J. ; Lappe, Joan M. ; Recker, Robert R. ; Lang, Thomas ; Guo, X. Edward. / Bone density, geometry, microstructure, and stiffness : Relationships between peripheral and central skeletal sites assessed by DXA, HR-pQCT, and cQCT in premenopausal women. In: Journal of Bone and Mineral Research. 2010 ; Vol. 25, No. 10. pp. 2229-2238.
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abstract = "High-resolution peripheral quantitative computed tomography (HR-pQCT) is a new in vivo imaging technique for assessing 3D microstructure of cortical and trabecular bone at the distal radius and tibia. No studies have investigated the extent to which measurements of the peripheral skeleton by HR-pQCT reflect those of the spine and hip, where the most serious fractures occur. To address this research question, we performed dual-energy X-ray absorptiometry (DXA), central QCT (cQCT), HR-pQCT, and image-based finite-element analyses on 69 premenopausal women to evaluate relationships among cortical and trabecular bone density, geometry, microstructure, and stiffness of the lumbar spine, proximal femur, distal radius, and distal tibia. Significant correlations were found between the stiffness of the two peripheral sites (r=0.86), two central sites (r=0.49), and, between the peripheral and central skeletal sites (r=0.56-0.70). These associations were explained in part by significant correlations in areal bone mineral density (aBMD), volumetric bone mineral density (vBMD), and cross-sectional area (CSA) between the multiple skeletal sites. For the prediction of proximal femoral stiffness, vBMD (r=0.75) and stiffness (r=0.69) of the distal tibia by HR-pQCT were comparable with direct measurements of the proximal femur: aBMD of the hip by DXA (r=0.70) and vBMD of the hip by cQCT (r=0.64). For the prediction of vertebral stiffness, trabecular vBMD (r=0.58) and stiffness (r=0.70) of distal radius by HR-pQCT were comparable with direct measurements of lumbar spine: aBMD by DXA (r=0.78) and vBMD by cQCT (r=0.67). Our results suggest that bone density and microstructural and mechanical properties measured by HR-pQCT of the distal radius and tibia reflect the mechanical competence of the central skeleton.",
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AU - Cohen, Adi

AU - Shane, Elizabeth

AU - Yin, Perry T.

AU - Stein, Emily M.

AU - Rogers, Halley

AU - Kokolus, Shannon L.

AU - McMahon, Donald J.

AU - Lappe, Joan M.

AU - Recker, Robert R.

AU - Lang, Thomas

AU - Guo, X. Edward

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