Abstract
High-resolution peripheral quantitative computed tomography (HR-pQCT) is a new in vivo imaging technique for assessing 3D microstructure of cortical and trabecular bone at the distal radius and tibia. No studies have investigated the extent to which measurements of the peripheral skeleton by HR-pQCT reflect those of the spine and hip, where the most serious fractures occur. To address this research question, we performed dual-energy X-ray absorptiometry (DXA), central QCT (cQCT), HR-pQCT, and image-based finite-element analyses on 69 premenopausal women to evaluate relationships among cortical and trabecular bone density, geometry, microstructure, and stiffness of the lumbar spine, proximal femur, distal radius, and distal tibia. Significant correlations were found between the stiffness of the two peripheral sites (r=0.86), two central sites (r=0.49), and, between the peripheral and central skeletal sites (r=0.56-0.70). These associations were explained in part by significant correlations in areal bone mineral density (aBMD), volumetric bone mineral density (vBMD), and cross-sectional area (CSA) between the multiple skeletal sites. For the prediction of proximal femoral stiffness, vBMD (r=0.75) and stiffness (r=0.69) of the distal tibia by HR-pQCT were comparable with direct measurements of the proximal femur: aBMD of the hip by DXA (r=0.70) and vBMD of the hip by cQCT (r=0.64). For the prediction of vertebral stiffness, trabecular vBMD (r=0.58) and stiffness (r=0.70) of distal radius by HR-pQCT were comparable with direct measurements of lumbar spine: aBMD by DXA (r=0.78) and vBMD by cQCT (r=0.67). Our results suggest that bone density and microstructural and mechanical properties measured by HR-pQCT of the distal radius and tibia reflect the mechanical competence of the central skeleton.
| Original language | English |
|---|---|
| Pages (from-to) | 2229-2238 |
| Number of pages | 10 |
| Journal | Journal of Bone and Mineral Research |
| Volume | 25 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 2010 |
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All Science Journal Classification (ASJC) codes
- Orthopedics and Sports Medicine
- Endocrinology, Diabetes and Metabolism
Cite this
Bone density, geometry, microstructure, and stiffness : Relationships between peripheral and central skeletal sites assessed by DXA, HR-pQCT, and cQCT in premenopausal women. / Liu, X. Sherry; Cohen, Adi; Shane, Elizabeth; Yin, Perry T.; Stein, Emily M.; Rogers, Halley; Kokolus, Shannon L.; McMahon, Donald J.; Lappe, Joan M.; Recker, Robert R.; Lang, Thomas; Guo, X. Edward.
In: Journal of Bone and Mineral Research, Vol. 25, No. 10, 10.2010, p. 2229-2238.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bone density, geometry, microstructure, and stiffness
T2 - Relationships between peripheral and central skeletal sites assessed by DXA, HR-pQCT, and cQCT in premenopausal women
AU - Liu, X. Sherry
AU - Cohen, Adi
AU - Shane, Elizabeth
AU - Yin, Perry T.
AU - Stein, Emily M.
AU - Rogers, Halley
AU - Kokolus, Shannon L.
AU - McMahon, Donald J.
AU - Lappe, Joan M.
AU - Recker, Robert R.
AU - Lang, Thomas
AU - Guo, X. Edward
PY - 2010/10
Y1 - 2010/10
N2 - High-resolution peripheral quantitative computed tomography (HR-pQCT) is a new in vivo imaging technique for assessing 3D microstructure of cortical and trabecular bone at the distal radius and tibia. No studies have investigated the extent to which measurements of the peripheral skeleton by HR-pQCT reflect those of the spine and hip, where the most serious fractures occur. To address this research question, we performed dual-energy X-ray absorptiometry (DXA), central QCT (cQCT), HR-pQCT, and image-based finite-element analyses on 69 premenopausal women to evaluate relationships among cortical and trabecular bone density, geometry, microstructure, and stiffness of the lumbar spine, proximal femur, distal radius, and distal tibia. Significant correlations were found between the stiffness of the two peripheral sites (r=0.86), two central sites (r=0.49), and, between the peripheral and central skeletal sites (r=0.56-0.70). These associations were explained in part by significant correlations in areal bone mineral density (aBMD), volumetric bone mineral density (vBMD), and cross-sectional area (CSA) between the multiple skeletal sites. For the prediction of proximal femoral stiffness, vBMD (r=0.75) and stiffness (r=0.69) of the distal tibia by HR-pQCT were comparable with direct measurements of the proximal femur: aBMD of the hip by DXA (r=0.70) and vBMD of the hip by cQCT (r=0.64). For the prediction of vertebral stiffness, trabecular vBMD (r=0.58) and stiffness (r=0.70) of distal radius by HR-pQCT were comparable with direct measurements of lumbar spine: aBMD by DXA (r=0.78) and vBMD by cQCT (r=0.67). Our results suggest that bone density and microstructural and mechanical properties measured by HR-pQCT of the distal radius and tibia reflect the mechanical competence of the central skeleton.
AB - High-resolution peripheral quantitative computed tomography (HR-pQCT) is a new in vivo imaging technique for assessing 3D microstructure of cortical and trabecular bone at the distal radius and tibia. No studies have investigated the extent to which measurements of the peripheral skeleton by HR-pQCT reflect those of the spine and hip, where the most serious fractures occur. To address this research question, we performed dual-energy X-ray absorptiometry (DXA), central QCT (cQCT), HR-pQCT, and image-based finite-element analyses on 69 premenopausal women to evaluate relationships among cortical and trabecular bone density, geometry, microstructure, and stiffness of the lumbar spine, proximal femur, distal radius, and distal tibia. Significant correlations were found between the stiffness of the two peripheral sites (r=0.86), two central sites (r=0.49), and, between the peripheral and central skeletal sites (r=0.56-0.70). These associations were explained in part by significant correlations in areal bone mineral density (aBMD), volumetric bone mineral density (vBMD), and cross-sectional area (CSA) between the multiple skeletal sites. For the prediction of proximal femoral stiffness, vBMD (r=0.75) and stiffness (r=0.69) of the distal tibia by HR-pQCT were comparable with direct measurements of the proximal femur: aBMD of the hip by DXA (r=0.70) and vBMD of the hip by cQCT (r=0.64). For the prediction of vertebral stiffness, trabecular vBMD (r=0.58) and stiffness (r=0.70) of distal radius by HR-pQCT were comparable with direct measurements of lumbar spine: aBMD by DXA (r=0.78) and vBMD by cQCT (r=0.67). Our results suggest that bone density and microstructural and mechanical properties measured by HR-pQCT of the distal radius and tibia reflect the mechanical competence of the central skeleton.
UR - http://www.scopus.com/inward/record.url?scp=77956834710&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956834710&partnerID=8YFLogxK
U2 - 10.1002/jbmr.111
DO - 10.1002/jbmr.111
M3 - Article
C2 - 20499344
AN - SCOPUS:77956834710
VL - 25
SP - 2229
EP - 2238
JO - Journal of Bone and Mineral Research
JF - Journal of Bone and Mineral Research
SN - 0884-0431
IS - 10
ER -