Abstract
Context: Odanacatib, a cathepsin K inhibitor, increases spine and hip areal bone mineral density (BMD)in postmenopausal women with low BMD and cortical thickness in ovariectomized monkeys. Objective: The objective of the study was to examine the impact of odanacatib on the trabecular and cortical bone compartments and estimated strength at the hip and spine. Design: This was a randomized, double-blind, 2-year trial. Setting: The study was conducted at a private or institutional practice. Participants: Participants included 214 postmenopausal women with low areal BMD. Intervention: The intervention included odanacatib 50 mg or placebo weekly. Main Outcome Measures: Changes in areal BMD by dual-energy x-ray absorptiometry (primary end point, 1 year areal BMD change at lumbar spine), bone turnover markers, volumetric BMD by quantitative computed tomography (QCT), and bone strength estimated by finite element analysis were measured. Results: Year 1 lumbar spine areal BMD percent change from baseline was 3.5% greater with odanacatib than placebo (P
| Original language | English |
|---|---|
| Pages (from-to) | 571-580 |
| Number of pages | 10 |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 98 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2013 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Clinical Biochemistry
- Endocrinology
- Biochemistry, medical
- Endocrinology, Diabetes and Metabolism
Cite this
Bone density, turnover, and estimated strength in postmenopausal women treated with odanacatib : A randomized trial. / Brixen, Kim; Chapurlat, Roland; Cheung, Angela M.; Keaveny, Tony M.; Fuerst, Thomas; Engelke, Klaus; Recker, Robert R.; Dardzinski, Bernard; Verbruggen, Nadia; Ather, Shabana; Rosenberg, Elizabeth; De Papp, Anne E.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 98, No. 2, 02.2013, p. 571-580.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bone density, turnover, and estimated strength in postmenopausal women treated with odanacatib
T2 - A randomized trial
AU - Brixen, Kim
AU - Chapurlat, Roland
AU - Cheung, Angela M.
AU - Keaveny, Tony M.
AU - Fuerst, Thomas
AU - Engelke, Klaus
AU - Recker, Robert R.
AU - Dardzinski, Bernard
AU - Verbruggen, Nadia
AU - Ather, Shabana
AU - Rosenberg, Elizabeth
AU - De Papp, Anne E.
PY - 2013/2
Y1 - 2013/2
N2 - Context: Odanacatib, a cathepsin K inhibitor, increases spine and hip areal bone mineral density (BMD)in postmenopausal women with low BMD and cortical thickness in ovariectomized monkeys. Objective: The objective of the study was to examine the impact of odanacatib on the trabecular and cortical bone compartments and estimated strength at the hip and spine. Design: This was a randomized, double-blind, 2-year trial. Setting: The study was conducted at a private or institutional practice. Participants: Participants included 214 postmenopausal women with low areal BMD. Intervention: The intervention included odanacatib 50 mg or placebo weekly. Main Outcome Measures: Changes in areal BMD by dual-energy x-ray absorptiometry (primary end point, 1 year areal BMD change at lumbar spine), bone turnover markers, volumetric BMD by quantitative computed tomography (QCT), and bone strength estimated by finite element analysis were measured. Results: Year 1 lumbar spine areal BMD percent change from baseline was 3.5% greater with odanacatib than placebo (P
AB - Context: Odanacatib, a cathepsin K inhibitor, increases spine and hip areal bone mineral density (BMD)in postmenopausal women with low BMD and cortical thickness in ovariectomized monkeys. Objective: The objective of the study was to examine the impact of odanacatib on the trabecular and cortical bone compartments and estimated strength at the hip and spine. Design: This was a randomized, double-blind, 2-year trial. Setting: The study was conducted at a private or institutional practice. Participants: Participants included 214 postmenopausal women with low areal BMD. Intervention: The intervention included odanacatib 50 mg or placebo weekly. Main Outcome Measures: Changes in areal BMD by dual-energy x-ray absorptiometry (primary end point, 1 year areal BMD change at lumbar spine), bone turnover markers, volumetric BMD by quantitative computed tomography (QCT), and bone strength estimated by finite element analysis were measured. Results: Year 1 lumbar spine areal BMD percent change from baseline was 3.5% greater with odanacatib than placebo (P
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U2 - 10.1210/jc.2012-2972
DO - 10.1210/jc.2012-2972
M3 - Article
VL - 98
SP - 571
EP - 580
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 2
ER -