Bone dimensional change with age

Interactions of genetic, hormonal, and body size variables

R. P. Heaney, M. J. Barger-Lux, K. M. Davies, R. A. Ryan, M. L. Johnson, G. Gong

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Changes in bony dimensions with age were assessed longitudinally from standardized X-ray films in 170 middle-aged Caucasian women, starting at age 40 years and with a median duration of observation of 21.125 years. Consistent with earlier work, cortical area of the metacarpals and radial shaft declined with age at rates ranging from 0.57 to 0.86%/year. As predicted, estrogen replacement therapy decreased this loss in a dose-dependent manner. Not previously reported is the fact that weight gain over the period of observation reduced upper extremity bone loss. Moreover, this protection was independent of the estrogen effect. In contrast with bone loss in the upper extremity, both femur shaft diameter and femur shaft cortical area increased significantly with age (0.23 and 0.26%/year, respectively). Estrogen replacement therapy inhibited femur shaft expansion but had no effect on femur cortical area. Weight change, however, strongly influenced gain (or loss) of femur cortical area: those in the highest weight change tertile gained 4 times as much cortical area as those in the lowest weight change tertile. VDR genotype also significantly influenced femoral shaft changes: women with the bb genotype had both greater shaft expansion and a greater increase in cortical area. The VDR effects were independent of the effects of weight change and estrogen. Femoral shaft expansion was of sufficient magnitude to suggest that the mechanical properties of the entire femur may change appreciably with age. Finally, contrary to widespread belief, there was significant, if modest, expansion at the femoral neck with age.

Original languageEnglish
Pages (from-to)426-431
Number of pages6
JournalOsteoporosis International
Volume7
Issue number5
DOIs
StatePublished - 1997

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Body Size
Femur
Bone and Bones
Weights and Measures
Estrogen Replacement Therapy
Thigh
Bones of Upper Extremity
Estrogens
Genotype
Observation
X-Ray Film
Metacarpal Bones
Femur Neck
Upper Extremity
Weight Gain

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Heaney, R. P., Barger-Lux, M. J., Davies, K. M., Ryan, R. A., Johnson, M. L., & Gong, G. (1997). Bone dimensional change with age: Interactions of genetic, hormonal, and body size variables. Osteoporosis International, 7(5), 426-431. https://doi.org/10.1007/PL00004150

Bone dimensional change with age : Interactions of genetic, hormonal, and body size variables. / Heaney, R. P.; Barger-Lux, M. J.; Davies, K. M.; Ryan, R. A.; Johnson, M. L.; Gong, G.

In: Osteoporosis International, Vol. 7, No. 5, 1997, p. 426-431.

Research output: Contribution to journalArticle

Heaney, RP, Barger-Lux, MJ, Davies, KM, Ryan, RA, Johnson, ML & Gong, G 1997, 'Bone dimensional change with age: Interactions of genetic, hormonal, and body size variables', Osteoporosis International, vol. 7, no. 5, pp. 426-431. https://doi.org/10.1007/PL00004150
Heaney, R. P. ; Barger-Lux, M. J. ; Davies, K. M. ; Ryan, R. A. ; Johnson, M. L. ; Gong, G. / Bone dimensional change with age : Interactions of genetic, hormonal, and body size variables. In: Osteoporosis International. 1997 ; Vol. 7, No. 5. pp. 426-431.
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