Bone histomorphometry in clinical practice

Robert R. Recker, Carolina Aguiar Moreira

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Histological examination of undecalcified transilial bone biopsy specimens is a valuable and well-established clinical and research tool for studying the etiology, pathogenesis, and treatment of metabolic bone diseases. This chapter reviews the organization and function of bone cells and identifies a set of basic structural and kinetic histomorphometric variables. Remodeling occurs in cancellous and haversian (cortical) bone. Bone biopsy specimens are ordinarily obtained at the transiliac site and shipped to specialized laboratories for processing and microscopic analysis. The chapter outlines an approach to interpretation of findings, with examples from a range of metabolic bone diseases and describes the techniques for obtaining, processing, and analyzing transilial biopsy specimens. It also identifies the clinical situations in which bone histomorphometry can be useful; and relates histomorphometric measures to data from other methods for assessing bone properties and bone physiology.

Original languageEnglish (US)
Title of host publicationPrimer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
Publisherwiley
Pages310-318
Number of pages9
ISBN (Electronic)9781119266594
ISBN (Print)9781119266563
DOIs
StatePublished - Jan 1 2018

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Recker, R. R., & Moreira, C. A. (2018). Bone histomorphometry in clinical practice. In Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism (pp. 310-318). wiley. https://doi.org/10.1002/9781119266594.ch39