Abstract
Histological examination of undecalcified transilial bone biopsy specimens is a valuable and well-established clinical and research tool for studying the etiology, pathogenesis, and treatment of metabolic bone diseases. This chapter reviews the organization and function of bone cells and identifies a set of basic structural and kinetic histomorphometric variables. Remodeling occurs in cancellous and haversian (cortical) bone. Bone biopsy specimens are ordinarily obtained at the transiliac site and shipped to specialized laboratories for processing and microscopic analysis. The chapter outlines an approach to interpretation of findings, with examples from a range of metabolic bone diseases and describes the techniques for obtaining, processing, and analyzing transilial biopsy specimens. It also identifies the clinical situations in which bone histomorphometry can be useful; and relates histomorphometric measures to data from other methods for assessing bone properties and bone physiology.
| Original language | English (US) |
|---|---|
| Title of host publication | Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism |
| Publisher | wiley |
| Pages | 310-318 |
| Number of pages | 9 |
| ISBN (Electronic) | 9781119266594 |
| ISBN (Print) | 9781119266563 |
| DOIs | |
| State | Published - Jan 1 2018 |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Bone histomorphometry in clinical practice. / Recker, Robert R.; Moreira, Carolina Aguiar.
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. wiley, 2018. p. 310-318.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Bone histomorphometry in clinical practice
AU - Recker, Robert R.
AU - Moreira, Carolina Aguiar
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Histological examination of undecalcified transilial bone biopsy specimens is a valuable and well-established clinical and research tool for studying the etiology, pathogenesis, and treatment of metabolic bone diseases. This chapter reviews the organization and function of bone cells and identifies a set of basic structural and kinetic histomorphometric variables. Remodeling occurs in cancellous and haversian (cortical) bone. Bone biopsy specimens are ordinarily obtained at the transiliac site and shipped to specialized laboratories for processing and microscopic analysis. The chapter outlines an approach to interpretation of findings, with examples from a range of metabolic bone diseases and describes the techniques for obtaining, processing, and analyzing transilial biopsy specimens. It also identifies the clinical situations in which bone histomorphometry can be useful; and relates histomorphometric measures to data from other methods for assessing bone properties and bone physiology.
AB - Histological examination of undecalcified transilial bone biopsy specimens is a valuable and well-established clinical and research tool for studying the etiology, pathogenesis, and treatment of metabolic bone diseases. This chapter reviews the organization and function of bone cells and identifies a set of basic structural and kinetic histomorphometric variables. Remodeling occurs in cancellous and haversian (cortical) bone. Bone biopsy specimens are ordinarily obtained at the transiliac site and shipped to specialized laboratories for processing and microscopic analysis. The chapter outlines an approach to interpretation of findings, with examples from a range of metabolic bone diseases and describes the techniques for obtaining, processing, and analyzing transilial biopsy specimens. It also identifies the clinical situations in which bone histomorphometry can be useful; and relates histomorphometric measures to data from other methods for assessing bone properties and bone physiology.
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UR - http://www.scopus.com/inward/citedby.url?scp=85060652493&partnerID=8YFLogxK
U2 - 10.1002/9781119266594.ch39
DO - 10.1002/9781119266594.ch39
M3 - Chapter
AN - SCOPUS:85060652493
SN - 9781119266563
SP - 310
EP - 318
BT - Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
PB - wiley
ER -