Abstract
Background: We have recently reported the role of environmental exposure in the ethnic diversity of bone mineral density (BMD). Potential genetic difference has not been adequately assessed. Purpose: To determine allele frequencies of EMD-affecting genes and their association with BMD in Africans. Methods: Allele frequencies at 18 polymorphic sites in 13 genes that affect BMD Asians and/or Caucasians were determined in 143 recent immigrants (55 men and 88 women, 18-51 years of age) from sob-Saharan Sudan to the United States. Genetic association studies were performed. Results. Among the 14 single-nucleotide polymorphisms (SNPs), 10 were significantry different in adele frequency between Sudanese and Asians, and 10 between Sudanese and Caucasians. Only the osteocalcin gene was not significantly different in allele frequency among Sudanese, Asians and Caucasians. Allele frequencies in the TGFβ, COLIA1 and CSR genes were extremely low (
| Original language | English |
|---|---|
| Pages (from-to) | 1102-1108 |
| Number of pages | 7 |
| Journal | Journal of the National Medical Association |
| Volume | 98 |
| Issue number | 7 |
| State | Published - Jul 2006 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
Cite this
Bone mineral density-affecting genes in Africans. / Gong, Gordon; Haynatzki, Gleb; Haynatzka, Vera; Howell, Ryan; Kosoko-Lasaki, Omofolasade; Fu, Yun Xin; Yu, Fei; Gallagher, John Christopher G.; Wilson, M. Roy.
In: Journal of the National Medical Association, Vol. 98, No. 7, 07.2006, p. 1102-1108.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bone mineral density-affecting genes in Africans
AU - Gong, Gordon
AU - Haynatzki, Gleb
AU - Haynatzka, Vera
AU - Howell, Ryan
AU - Kosoko-Lasaki, Omofolasade
AU - Fu, Yun Xin
AU - Yu, Fei
AU - Gallagher, John Christopher G.
AU - Wilson, M. Roy
PY - 2006/7
Y1 - 2006/7
N2 - Background: We have recently reported the role of environmental exposure in the ethnic diversity of bone mineral density (BMD). Potential genetic difference has not been adequately assessed. Purpose: To determine allele frequencies of EMD-affecting genes and their association with BMD in Africans. Methods: Allele frequencies at 18 polymorphic sites in 13 genes that affect BMD Asians and/or Caucasians were determined in 143 recent immigrants (55 men and 88 women, 18-51 years of age) from sob-Saharan Sudan to the United States. Genetic association studies were performed. Results. Among the 14 single-nucleotide polymorphisms (SNPs), 10 were significantry different in adele frequency between Sudanese and Asians, and 10 between Sudanese and Caucasians. Only the osteocalcin gene was not significantly different in allele frequency among Sudanese, Asians and Caucasians. Allele frequencies in the TGFβ, COLIA1 and CSR genes were extremely low (
AB - Background: We have recently reported the role of environmental exposure in the ethnic diversity of bone mineral density (BMD). Potential genetic difference has not been adequately assessed. Purpose: To determine allele frequencies of EMD-affecting genes and their association with BMD in Africans. Methods: Allele frequencies at 18 polymorphic sites in 13 genes that affect BMD Asians and/or Caucasians were determined in 143 recent immigrants (55 men and 88 women, 18-51 years of age) from sob-Saharan Sudan to the United States. Genetic association studies were performed. Results. Among the 14 single-nucleotide polymorphisms (SNPs), 10 were significantry different in adele frequency between Sudanese and Asians, and 10 between Sudanese and Caucasians. Only the osteocalcin gene was not significantly different in allele frequency among Sudanese, Asians and Caucasians. Allele frequencies in the TGFβ, COLIA1 and CSR genes were extremely low (
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M3 - Article
VL - 98
SP - 1102
EP - 1108
JO - Journal of the National Medical Association
JF - Journal of the National Medical Association
SN - 1943-4693
IS - 7
ER -