Bone mineral density-affecting genes in Africans

Gordon Gong; Gleb Haynatzki; Vera Haynatzka; Ryan Howell; Sade Kosoko-Lasaki; Yun Xin Fu; Fei Yu; John C. Gallagher; M. Roy Wilson

Bone mineral density-affecting genes in Africans

Gordon Gong, Gleb Haynatzki, Vera Haynatzka, Ryan Howell, Sade Kosoko-Lasaki, Yun Xin Fu, Fei Yu, John C. Gallagher, M. Roy Wilson

Health Sciences Multicultural and Community Affairs

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Background: We have recently reported the role of environmental exposure in the ethnic diversity of bone mineral density (BMD). Potential genetic difference has not been adequately assessed. Purpose: To determine allele frequencies of EMD-affecting genes and their association with BMD in Africans. Methods: Allele frequencies at 18 polymorphic sites in 13 genes that affect BMD Asians and/or Caucasians were determined in 143 recent immigrants (55 men and 88 women, 18-51 years of age) from sob-Saharan Sudan to the United States. Genetic association studies were performed. Results. Among the 14 single-nucleotide polymorphisms (SNPs), 10 were significantry different in adele frequency between Sudanese and Asians, and 10 between Sudanese and Caucasians. Only the osteocalcin gene was not significantly different in allele frequency among Sudanese, Asians and Caucasians. Allele frequencies in the TGFβ, COLIA1 and CSR genes were extremely low (

Original language	English (US)
Pages (from-to)	1102-1108
Number of pages	7
Journal	Journal of the National Medical Association
Volume	98
Issue number	7
State	Published - Jul 1 2006

All Science Journal Classification (ASJC) codes

Medicine(all)

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title = "Bone mineral density-affecting genes in Africans",

abstract = "Background: We have recently reported the role of environmental exposure in the ethnic diversity of bone mineral density (BMD). Potential genetic difference has not been adequately assessed. Purpose: To determine allele frequencies of EMD-affecting genes and their association with BMD in Africans. Methods: Allele frequencies at 18 polymorphic sites in 13 genes that affect BMD Asians and/or Caucasians were determined in 143 recent immigrants (55 men and 88 women, 18-51 years of age) from sob-Saharan Sudan to the United States. Genetic association studies were performed. Results. Among the 14 single-nucleotide polymorphisms (SNPs), 10 were significantry different in adele frequency between Sudanese and Asians, and 10 between Sudanese and Caucasians. Only the osteocalcin gene was not significantly different in allele frequency among Sudanese, Asians and Caucasians. Allele frequencies in the TGFβ, COLIA1 and CSR genes were extremely low (",

author = "Gordon Gong and Gleb Haynatzki and Vera Haynatzka and Ryan Howell and Sade Kosoko-Lasaki and Fu, {Yun Xin} and Fei Yu and Gallagher, {John C.} and Wilson, {M. Roy}",

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T1 - Bone mineral density-affecting genes in Africans

AU - Gong, Gordon

AU - Haynatzki, Gleb

AU - Haynatzka, Vera

AU - Howell, Ryan

AU - Kosoko-Lasaki, Sade

AU - Fu, Yun Xin

AU - Yu, Fei

AU - Gallagher, John C.

AU - Wilson, M. Roy

PY - 2006/7/1

Y1 - 2006/7/1

N2 - Background: We have recently reported the role of environmental exposure in the ethnic diversity of bone mineral density (BMD). Potential genetic difference has not been adequately assessed. Purpose: To determine allele frequencies of EMD-affecting genes and their association with BMD in Africans. Methods: Allele frequencies at 18 polymorphic sites in 13 genes that affect BMD Asians and/or Caucasians were determined in 143 recent immigrants (55 men and 88 women, 18-51 years of age) from sob-Saharan Sudan to the United States. Genetic association studies were performed. Results. Among the 14 single-nucleotide polymorphisms (SNPs), 10 were significantry different in adele frequency between Sudanese and Asians, and 10 between Sudanese and Caucasians. Only the osteocalcin gene was not significantly different in allele frequency among Sudanese, Asians and Caucasians. Allele frequencies in the TGFβ, COLIA1 and CSR genes were extremely low (

AB - Background: We have recently reported the role of environmental exposure in the ethnic diversity of bone mineral density (BMD). Potential genetic difference has not been adequately assessed. Purpose: To determine allele frequencies of EMD-affecting genes and their association with BMD in Africans. Methods: Allele frequencies at 18 polymorphic sites in 13 genes that affect BMD Asians and/or Caucasians were determined in 143 recent immigrants (55 men and 88 women, 18-51 years of age) from sob-Saharan Sudan to the United States. Genetic association studies were performed. Results. Among the 14 single-nucleotide polymorphisms (SNPs), 10 were significantry different in adele frequency between Sudanese and Asians, and 10 between Sudanese and Caucasians. Only the osteocalcin gene was not significantly different in allele frequency among Sudanese, Asians and Caucasians. Allele frequencies in the TGFβ, COLIA1 and CSR genes were extremely low (

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