Bone mineral density and biochemical markers of bone turnover in healthy elderly men and women

Elizabeth A. Krall, Bess Dawson-Hughes, Kathryn Hirst, John Christopher G. Gallagher, Sheryl S. Sherman, Gail Dalsky

Research output: Contribution to journalArticle

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Abstract

Background. Osteoporosis risk in middle-aged women is twofold greater than that in men, and the difference increases with age. Gender differences in bone mineral density, estimated rates of bone loss, and usefulness of markers of bone metabolism for predicting bone density have not been well described in healthy elders aged 65 and above. The purpose of this cross- sectional analysis was to describe associations of bone mineral density at the hip, spine, and whole body with age, serum osteocalcin, and urinary N- telopeptide crosslinks of Type I collagen in healthy elderly men and women. Methods. A total of 1,087 healthy adults (273 men and 814 women) aged 65 to 87 years were enrolled in a collaborative study at 3 sties: Tufts University (Boston, MA), University of Connecticut Health Center (Farmington, CT), and Creighton University (Omaha, NE). Bone mineral density (BMD) at three regions of the hip, the lumbar spine, and whole body was determined by dual energy x- ray absorptiometry. Serum osteocalcin was measured by immunoassay, and measurement of N-telopeptide crosslinks (Ntx) in urine was made using an enzyme linked radioimmunoassay (ELISA). Results. Among women, the age- related decline in BMD at all non-spine skeletal sites was significantly different from zero, with the largest decline seen at the femoral neck (- .0038 g/cm 2/y, p <.001) and the smallest at the trochanter of the hip (- .0023 g/cm 2/y, p = .03). Among men, the changes at all non-spine sites were not significant. In both sexes, spine BMD tended to increase with age (men, + .0045 g/cm 2/y, women, + .0003 g/cm 2/y). Serum osteocalcin and urinary Ntx were inversely related to BMD at all skeletal sites, but the weakest associations were observed at the spine. Individuals whose values of both osteocalcin and Ntx were in the lowest quartiles of the respective sex- specific distributions had mean femoral neck BMD that were 11% higher than individuals with marker values in the highest quartiles. Conclusions. These findings suggest that age-related decreases in BMD may vary by gender and skeletal site. Determinations of osteocalcin and N-telopeptide crosslinks at a single point in time may potentially be used as indicators of current bone status, particularly at non-spine skeletal sites.

Original languageEnglish
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume52
Issue number2
StatePublished - 1997

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Bone Remodeling
Bone Density
Biomarkers
Osteocalcin
Spine
Hip
Femur Neck
Bone and Bones
Hordeolum
Serum
Lumbosacral Region
Sex Distribution
Collagen Type I
Immunoassay
Femur
Osteoporosis
Radioimmunoassay
Cross-Sectional Studies
X-Rays
Urine

All Science Journal Classification (ASJC) codes

  • Aging

Cite this

Bone mineral density and biochemical markers of bone turnover in healthy elderly men and women. / Krall, Elizabeth A.; Dawson-Hughes, Bess; Hirst, Kathryn; Gallagher, John Christopher G.; Sherman, Sheryl S.; Dalsky, Gail.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 52, No. 2, 1997.

Research output: Contribution to journalArticle

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title = "Bone mineral density and biochemical markers of bone turnover in healthy elderly men and women",
abstract = "Background. Osteoporosis risk in middle-aged women is twofold greater than that in men, and the difference increases with age. Gender differences in bone mineral density, estimated rates of bone loss, and usefulness of markers of bone metabolism for predicting bone density have not been well described in healthy elders aged 65 and above. The purpose of this cross- sectional analysis was to describe associations of bone mineral density at the hip, spine, and whole body with age, serum osteocalcin, and urinary N- telopeptide crosslinks of Type I collagen in healthy elderly men and women. Methods. A total of 1,087 healthy adults (273 men and 814 women) aged 65 to 87 years were enrolled in a collaborative study at 3 sties: Tufts University (Boston, MA), University of Connecticut Health Center (Farmington, CT), and Creighton University (Omaha, NE). Bone mineral density (BMD) at three regions of the hip, the lumbar spine, and whole body was determined by dual energy x- ray absorptiometry. Serum osteocalcin was measured by immunoassay, and measurement of N-telopeptide crosslinks (Ntx) in urine was made using an enzyme linked radioimmunoassay (ELISA). Results. Among women, the age- related decline in BMD at all non-spine skeletal sites was significantly different from zero, with the largest decline seen at the femoral neck (- .0038 g/cm 2/y, p <.001) and the smallest at the trochanter of the hip (- .0023 g/cm 2/y, p = .03). Among men, the changes at all non-spine sites were not significant. In both sexes, spine BMD tended to increase with age (men, + .0045 g/cm 2/y, women, + .0003 g/cm 2/y). Serum osteocalcin and urinary Ntx were inversely related to BMD at all skeletal sites, but the weakest associations were observed at the spine. Individuals whose values of both osteocalcin and Ntx were in the lowest quartiles of the respective sex- specific distributions had mean femoral neck BMD that were 11{\%} higher than individuals with marker values in the highest quartiles. Conclusions. These findings suggest that age-related decreases in BMD may vary by gender and skeletal site. Determinations of osteocalcin and N-telopeptide crosslinks at a single point in time may potentially be used as indicators of current bone status, particularly at non-spine skeletal sites.",
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T1 - Bone mineral density and biochemical markers of bone turnover in healthy elderly men and women

AU - Krall, Elizabeth A.

AU - Dawson-Hughes, Bess

AU - Hirst, Kathryn

AU - Gallagher, John Christopher G.

AU - Sherman, Sheryl S.

AU - Dalsky, Gail

PY - 1997

Y1 - 1997

N2 - Background. Osteoporosis risk in middle-aged women is twofold greater than that in men, and the difference increases with age. Gender differences in bone mineral density, estimated rates of bone loss, and usefulness of markers of bone metabolism for predicting bone density have not been well described in healthy elders aged 65 and above. The purpose of this cross- sectional analysis was to describe associations of bone mineral density at the hip, spine, and whole body with age, serum osteocalcin, and urinary N- telopeptide crosslinks of Type I collagen in healthy elderly men and women. Methods. A total of 1,087 healthy adults (273 men and 814 women) aged 65 to 87 years were enrolled in a collaborative study at 3 sties: Tufts University (Boston, MA), University of Connecticut Health Center (Farmington, CT), and Creighton University (Omaha, NE). Bone mineral density (BMD) at three regions of the hip, the lumbar spine, and whole body was determined by dual energy x- ray absorptiometry. Serum osteocalcin was measured by immunoassay, and measurement of N-telopeptide crosslinks (Ntx) in urine was made using an enzyme linked radioimmunoassay (ELISA). Results. Among women, the age- related decline in BMD at all non-spine skeletal sites was significantly different from zero, with the largest decline seen at the femoral neck (- .0038 g/cm 2/y, p <.001) and the smallest at the trochanter of the hip (- .0023 g/cm 2/y, p = .03). Among men, the changes at all non-spine sites were not significant. In both sexes, spine BMD tended to increase with age (men, + .0045 g/cm 2/y, women, + .0003 g/cm 2/y). Serum osteocalcin and urinary Ntx were inversely related to BMD at all skeletal sites, but the weakest associations were observed at the spine. Individuals whose values of both osteocalcin and Ntx were in the lowest quartiles of the respective sex- specific distributions had mean femoral neck BMD that were 11% higher than individuals with marker values in the highest quartiles. Conclusions. These findings suggest that age-related decreases in BMD may vary by gender and skeletal site. Determinations of osteocalcin and N-telopeptide crosslinks at a single point in time may potentially be used as indicators of current bone status, particularly at non-spine skeletal sites.

AB - Background. Osteoporosis risk in middle-aged women is twofold greater than that in men, and the difference increases with age. Gender differences in bone mineral density, estimated rates of bone loss, and usefulness of markers of bone metabolism for predicting bone density have not been well described in healthy elders aged 65 and above. The purpose of this cross- sectional analysis was to describe associations of bone mineral density at the hip, spine, and whole body with age, serum osteocalcin, and urinary N- telopeptide crosslinks of Type I collagen in healthy elderly men and women. Methods. A total of 1,087 healthy adults (273 men and 814 women) aged 65 to 87 years were enrolled in a collaborative study at 3 sties: Tufts University (Boston, MA), University of Connecticut Health Center (Farmington, CT), and Creighton University (Omaha, NE). Bone mineral density (BMD) at three regions of the hip, the lumbar spine, and whole body was determined by dual energy x- ray absorptiometry. Serum osteocalcin was measured by immunoassay, and measurement of N-telopeptide crosslinks (Ntx) in urine was made using an enzyme linked radioimmunoassay (ELISA). Results. Among women, the age- related decline in BMD at all non-spine skeletal sites was significantly different from zero, with the largest decline seen at the femoral neck (- .0038 g/cm 2/y, p <.001) and the smallest at the trochanter of the hip (- .0023 g/cm 2/y, p = .03). Among men, the changes at all non-spine sites were not significant. In both sexes, spine BMD tended to increase with age (men, + .0045 g/cm 2/y, women, + .0003 g/cm 2/y). Serum osteocalcin and urinary Ntx were inversely related to BMD at all skeletal sites, but the weakest associations were observed at the spine. Individuals whose values of both osteocalcin and Ntx were in the lowest quartiles of the respective sex- specific distributions had mean femoral neck BMD that were 11% higher than individuals with marker values in the highest quartiles. Conclusions. These findings suggest that age-related decreases in BMD may vary by gender and skeletal site. Determinations of osteocalcin and N-telopeptide crosslinks at a single point in time may potentially be used as indicators of current bone status, particularly at non-spine skeletal sites.

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