Bone remodeling alterations in myelodysplastic syndrome

Leonardo Mellibovsky, A. Diez, S. Serrano, J. Aubia, E. Pérez-Vila, M. L. Mariñoso, X. Nogués, Robert R. Recker

Research output: Contribution to journalArticle

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Abstract

There is a close relationship between hematopoietic bone marrow and bone cells. Thus, the profound derangement of hematopoiesis in myelodysplastic syndromes (MDS) might be expected to affect bone cell function. We studied the dynamic histomorphometric changes in bone in 22 MDS patients to examine this relationship and analyze the influence of hematological disease on bone remodeling. Bone-regulating hormones and histomorphometry of undecalcified transiliac bone biopsies, after double tetracycline labeling, were studied. Serum calcium, phosphorus, creatinine, alkaline phophatase, osteocalcin, iPTH, 25(OH)D3, 1,25(OH)2D3, hydroxyprolinuria, and calcium/creatinine ratio in urine were normal compared with controls. Histomorphometry showed a significant decrease in osteoblast surface (Ob.S/BS) (0.30 ± 0.40 vs. 0.8 ± 1.1, p = 0.031), wall thickness (W.Th), (22.03 ± 5.5 vs. 31.8 ± 5.8, p <0.005), osteoclast number (N.Oc/T.Ar) (0.004 c 0.01 vs. 0.017 ± 0.01, p = 0.03), mineral apposition rate (MAR) (0.16 ± 0.15 vs. 0.53 ± 0.19, p <0.005), bone formation rate, surface referent (BFR/BS) (0.004 ± 0.10 vs. 0.016 ± 0.016, p = 0.009), and activation frequency (Ac.f) (0.06 ± 0.07 vs. 0.21 ± 0.23, p = 0.008). An increase in mineralization lag time (MLT) (119.2 ± 78.6 vs. 29.6 ± 77, p <0.005), (mean ± SD, unpaired Student t-test) was observed. Bone volume (BV/TV), eroded surfaces (ES/BS), and osteoid thickness (O.Th) remained unchanged. This picture of adynamic bone with decreased mineral apposition rate and markedly decreased osteoclast number is a characteristic finding in MDS patients. Thus, bone histomorphometric findings in MDS patients show the relationships and interactions between hematopoietic and bone cells.

Original languageEnglish
Pages (from-to)401-405
Number of pages5
JournalBone
Volume19
Issue number4
DOIs
StatePublished - Oct 1996

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Bone Remodeling
Myelodysplastic Syndromes
Bone and Bones
Osteoclasts
Minerals
Creatinine
Calcium
Hematologic Diseases
Osteocalcin
Hematopoiesis
Tetracycline
Osteoblasts
Osteogenesis
Bone Marrow Cells
Phosphorus
Urine
Hormones
Students
Biopsy

All Science Journal Classification (ASJC) codes

  • Physiology
  • Hematology

Cite this

Mellibovsky, L., Diez, A., Serrano, S., Aubia, J., Pérez-Vila, E., Mariñoso, M. L., ... Recker, R. R. (1996). Bone remodeling alterations in myelodysplastic syndrome. Bone, 19(4), 401-405. https://doi.org/10.1016/S8756-3282(96)00210-4

Bone remodeling alterations in myelodysplastic syndrome. / Mellibovsky, Leonardo; Diez, A.; Serrano, S.; Aubia, J.; Pérez-Vila, E.; Mariñoso, M. L.; Nogués, X.; Recker, Robert R.

In: Bone, Vol. 19, No. 4, 10.1996, p. 401-405.

Research output: Contribution to journalArticle

Mellibovsky, L, Diez, A, Serrano, S, Aubia, J, Pérez-Vila, E, Mariñoso, ML, Nogués, X & Recker, RR 1996, 'Bone remodeling alterations in myelodysplastic syndrome', Bone, vol. 19, no. 4, pp. 401-405. https://doi.org/10.1016/S8756-3282(96)00210-4
Mellibovsky L, Diez A, Serrano S, Aubia J, Pérez-Vila E, Mariñoso ML et al. Bone remodeling alterations in myelodysplastic syndrome. Bone. 1996 Oct;19(4):401-405. https://doi.org/10.1016/S8756-3282(96)00210-4
Mellibovsky, Leonardo ; Diez, A. ; Serrano, S. ; Aubia, J. ; Pérez-Vila, E. ; Mariñoso, M. L. ; Nogués, X. ; Recker, Robert R. / Bone remodeling alterations in myelodysplastic syndrome. In: Bone. 1996 ; Vol. 19, No. 4. pp. 401-405.
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