Abstract
Bone remodeling rates (Ac.f) were measured in transilial biopsy specimens from 50 healthy premenopausal women before and 1 year after menopause, in 34 healthy women 13 years past menopause, and in 89 women with untreated osteoporosis. Ac.f nearly doubled 1 year after menopause, tripled 13 years after menopause, and remained elevated in women with osteoporosis. Introduction: Increased bone remodeling rates are associated with increased skeletal fragility independent of bone mass, partially accounting for the age-related increase in fracture risk in women that is independent of bone loss. We examined bone remodeling rates before and after menopause and in women with osteoporosis by measurements of activation frequency (Ac.f, #/year) in transilial bone biopsy specimens. Materials and Methods: We recruited 75 women, >46 years old, who had premenopausal estradiol and gonadotropin levels and regular menses. During 9.5 years of observation, 50 women experienced normal menopause and had 2 transilial bone biopsy specimens after tetracycline labeling, one at the beginning of observation and the second 12 months after the last menses, when serum follicle-stimulating hormone (FSH) was >75 mIU/ml and serum estradiol was
| Original language | English |
|---|---|
| Pages (from-to) | 1628-1633 |
| Number of pages | 6 |
| Journal | Journal of Bone and Mineral Research |
| Volume | 19 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 2004 |
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All Science Journal Classification (ASJC) codes
- Surgery
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Bone remodeling increases substantially in the years after menopause and remains increased in older osteoporosis patients. / Recker, Robert R.; Lappe, Joan M.; Davies, K. Michael; Heaney, Robert.
In: Journal of Bone and Mineral Research, Vol. 19, No. 10, 10.2004, p. 1628-1633.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bone remodeling increases substantially in the years after menopause and remains increased in older osteoporosis patients
AU - Recker, Robert R.
AU - Lappe, Joan M.
AU - Davies, K. Michael
AU - Heaney, Robert
PY - 2004/10
Y1 - 2004/10
N2 - Bone remodeling rates (Ac.f) were measured in transilial biopsy specimens from 50 healthy premenopausal women before and 1 year after menopause, in 34 healthy women 13 years past menopause, and in 89 women with untreated osteoporosis. Ac.f nearly doubled 1 year after menopause, tripled 13 years after menopause, and remained elevated in women with osteoporosis. Introduction: Increased bone remodeling rates are associated with increased skeletal fragility independent of bone mass, partially accounting for the age-related increase in fracture risk in women that is independent of bone loss. We examined bone remodeling rates before and after menopause and in women with osteoporosis by measurements of activation frequency (Ac.f, #/year) in transilial bone biopsy specimens. Materials and Methods: We recruited 75 women, >46 years old, who had premenopausal estradiol and gonadotropin levels and regular menses. During 9.5 years of observation, 50 women experienced normal menopause and had 2 transilial bone biopsy specimens after tetracycline labeling, one at the beginning of observation and the second 12 months after the last menses, when serum follicle-stimulating hormone (FSH) was >75 mIU/ml and serum estradiol was
AB - Bone remodeling rates (Ac.f) were measured in transilial biopsy specimens from 50 healthy premenopausal women before and 1 year after menopause, in 34 healthy women 13 years past menopause, and in 89 women with untreated osteoporosis. Ac.f nearly doubled 1 year after menopause, tripled 13 years after menopause, and remained elevated in women with osteoporosis. Introduction: Increased bone remodeling rates are associated with increased skeletal fragility independent of bone mass, partially accounting for the age-related increase in fracture risk in women that is independent of bone loss. We examined bone remodeling rates before and after menopause and in women with osteoporosis by measurements of activation frequency (Ac.f, #/year) in transilial bone biopsy specimens. Materials and Methods: We recruited 75 women, >46 years old, who had premenopausal estradiol and gonadotropin levels and regular menses. During 9.5 years of observation, 50 women experienced normal menopause and had 2 transilial bone biopsy specimens after tetracycline labeling, one at the beginning of observation and the second 12 months after the last menses, when serum follicle-stimulating hormone (FSH) was >75 mIU/ml and serum estradiol was
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U2 - 10.1359/JBMR.040710
DO - 10.1359/JBMR.040710
M3 - Article
VL - 19
SP - 1628
EP - 1633
JO - Journal of Bone and Mineral Research
JF - Journal of Bone and Mineral Research
SN - 0884-0431
IS - 10
ER -