Bone remodeling increases substantially in the years after menopause and remains increased in older osteoporosis patients

Robert R. Recker, Joan M. Lappe, K. Michael Davies, Robert Heaney

Research output: Contribution to journalArticle

198 Citations (Scopus)

Abstract

Bone remodeling rates (Ac.f) were measured in transilial biopsy specimens from 50 healthy premenopausal women before and 1 year after menopause, in 34 healthy women 13 years past menopause, and in 89 women with untreated osteoporosis. Ac.f nearly doubled 1 year after menopause, tripled 13 years after menopause, and remained elevated in women with osteoporosis. Introduction: Increased bone remodeling rates are associated with increased skeletal fragility independent of bone mass, partially accounting for the age-related increase in fracture risk in women that is independent of bone loss. We examined bone remodeling rates before and after menopause and in women with osteoporosis by measurements of activation frequency (Ac.f, #/year) in transilial bone biopsy specimens. Materials and Methods: We recruited 75 women, >46 years old, who had premenopausal estradiol and gonadotropin levels and regular menses. During 9.5 years of observation, 50 women experienced normal menopause and had 2 transilial bone biopsy specimens after tetracycline labeling, one at the beginning of observation and the second 12 months after the last menses, when serum follicle-stimulating hormone (FSH) was >75 mIU/ml and serum estradiol was

Original languageEnglish
Pages (from-to)1628-1633
Number of pages6
JournalJournal of Bone and Mineral Research
Volume19
Issue number10
DOIs
StatePublished - Oct 2004

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Bone Remodeling
Menopause
Osteoporosis
Bone and Bones
Menstruation
Biopsy
Estradiol
Observation
Follicle Stimulating Hormone
Tetracycline
Serum
Gonadotropins

All Science Journal Classification (ASJC) codes

  • Surgery

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Bone remodeling increases substantially in the years after menopause and remains increased in older osteoporosis patients. / Recker, Robert R.; Lappe, Joan M.; Davies, K. Michael; Heaney, Robert.

In: Journal of Bone and Mineral Research, Vol. 19, No. 10, 10.2004, p. 1628-1633.

Research output: Contribution to journalArticle

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