Brain injury and neural stem cells

Parker E. Ludwig, Finosh G. Thankam, Arun A. Patil, Andrea J. Chamczuk, Devendra K. Agrawal

Research output: Contribution to journalReview article

Abstract

Many therapies with potential for treatment of brain injury have been investigated. Few types of cells have spurred as much interest and excitement as stem cells over the past few decades. The multipotentiality and self-renewing characteristics of stem cells confer upon them the capability to regenerate lost tissue in ischemic or degenerative conditions as well as trauma. While stem cells have not yet proven to be clinically effective in many such conditions as was once hoped, they have demonstrated some effects that could be manipulated for clinical benefit. The various types of stem cells have similar characteristics, and largely differ in terms of origin; those that have differentiated to some extent may exhibit limited capability in differentiation potential. Stem cells can aid in decreasing lesion size and improving function following brain injury.

LanguageEnglish (US)
Pages7-18
Number of pages12
JournalNeural Regeneration Research
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

Fingerprint

Neural Stem Cells
Brain Injuries
Stem Cells
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Developmental Neuroscience

Cite this

Ludwig, P. E., Thankam, F. G., Patil, A. A., Chamczuk, A. J., & Agrawal, D. K. (2018). Brain injury and neural stem cells. Neural Regeneration Research, 13(1), 7-18. https://doi.org/10.4103/1673-5374.224361

Brain injury and neural stem cells. / Ludwig, Parker E.; Thankam, Finosh G.; Patil, Arun A.; Chamczuk, Andrea J.; Agrawal, Devendra K.

In: Neural Regeneration Research, Vol. 13, No. 1, 01.01.2018, p. 7-18.

Research output: Contribution to journalReview article

Ludwig, PE, Thankam, FG, Patil, AA, Chamczuk, AJ & Agrawal, DK 2018, 'Brain injury and neural stem cells' Neural Regeneration Research, vol. 13, no. 1, pp. 7-18. https://doi.org/10.4103/1673-5374.224361
Ludwig, Parker E. ; Thankam, Finosh G. ; Patil, Arun A. ; Chamczuk, Andrea J. ; Agrawal, Devendra K. / Brain injury and neural stem cells. In: Neural Regeneration Research. 2018 ; Vol. 13, No. 1. pp. 7-18.
@article{5dfce02769d14e6886291ea8c6b1c22a,
title = "Brain injury and neural stem cells",
abstract = "Many therapies with potential for treatment of brain injury have been investigated. Few types of cells have spurred as much interest and excitement as stem cells over the past few decades. The multipotentiality and self-renewing characteristics of stem cells confer upon them the capability to regenerate lost tissue in ischemic or degenerative conditions as well as trauma. While stem cells have not yet proven to be clinically effective in many such conditions as was once hoped, they have demonstrated some effects that could be manipulated for clinical benefit. The various types of stem cells have similar characteristics, and largely differ in terms of origin; those that have differentiated to some extent may exhibit limited capability in differentiation potential. Stem cells can aid in decreasing lesion size and improving function following brain injury.",
author = "Ludwig, {Parker E.} and Thankam, {Finosh G.} and Patil, {Arun A.} and Chamczuk, {Andrea J.} and Agrawal, {Devendra K.}",
year = "2018",
month = "1",
day = "1",
doi = "10.4103/1673-5374.224361",
language = "English (US)",
volume = "13",
pages = "7--18",
journal = "Neural Regeneration Research",
issn = "1673-5374",
publisher = "Editorial Board of Neural Regeneration Research",
number = "1",

}

TY - JOUR

T1 - Brain injury and neural stem cells

AU - Ludwig, Parker E.

AU - Thankam, Finosh G.

AU - Patil, Arun A.

AU - Chamczuk, Andrea J.

AU - Agrawal, Devendra K.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Many therapies with potential for treatment of brain injury have been investigated. Few types of cells have spurred as much interest and excitement as stem cells over the past few decades. The multipotentiality and self-renewing characteristics of stem cells confer upon them the capability to regenerate lost tissue in ischemic or degenerative conditions as well as trauma. While stem cells have not yet proven to be clinically effective in many such conditions as was once hoped, they have demonstrated some effects that could be manipulated for clinical benefit. The various types of stem cells have similar characteristics, and largely differ in terms of origin; those that have differentiated to some extent may exhibit limited capability in differentiation potential. Stem cells can aid in decreasing lesion size and improving function following brain injury.

AB - Many therapies with potential for treatment of brain injury have been investigated. Few types of cells have spurred as much interest and excitement as stem cells over the past few decades. The multipotentiality and self-renewing characteristics of stem cells confer upon them the capability to regenerate lost tissue in ischemic or degenerative conditions as well as trauma. While stem cells have not yet proven to be clinically effective in many such conditions as was once hoped, they have demonstrated some effects that could be manipulated for clinical benefit. The various types of stem cells have similar characteristics, and largely differ in terms of origin; those that have differentiated to some extent may exhibit limited capability in differentiation potential. Stem cells can aid in decreasing lesion size and improving function following brain injury.

UR - http://www.scopus.com/inward/record.url?scp=85051927141&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85051927141&partnerID=8YFLogxK

U2 - 10.4103/1673-5374.224361

DO - 10.4103/1673-5374.224361

M3 - Review article

VL - 13

SP - 7

EP - 18

JO - Neural Regeneration Research

T2 - Neural Regeneration Research

JF - Neural Regeneration Research

SN - 1673-5374

IS - 1

ER -