BRCA1 and BRCA2 families and the risk of skin cancer

Ophira M. Ginsburg, Charmaine Kim-Sing, William D. Foulkes, Parviz Ghadirian, Henry T. Lynch, Ping Sun, Steven A. Narod

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Abstract

BRCA1 and BRCA2 mutation carriers have elevated risks of breast and ovarian cancers. The risks for cancers at other sites remain unclear. Melanoma has been associated with BRCA2 mutations in some studies, however, few surveys have included non-melanoma skin cancer. We followed 2729 women with a BRCA1 or BRCA2 mutation for an average of 5.0 years. These women were asked to report new cases of cancer diagnosed in themselves or in their family. The risks of skin cancer were compared for probands with BRCA1 and BRCA2 mutations. Of 1779 women with a BRCA1 mutation, 29 developed skin cancer in the follow-up period (1.6%). Of the 950 women with a BRCA2 mutation, 28 developed skin cancer (3.0%) (OR = 1.83 for BRCA2 versus BRCA1; 95% CI 1.08-3.10; P = 0.02). The odds ratio for basal cell carcinoma was higher (OR = 3.8; 95% CI 1.5-9.4; P = 0.002). BRCA2 mutation carriers are at increased risk for skin cancer, compared with BRCA1 carriers, in particular for basal cell carcinoma.

Original languageEnglish
Pages (from-to)489-493
Number of pages5
JournalFamilial Cancer
Volume9
Issue number4
DOIs
StatePublished - Dec 2010

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Skin Neoplasms
Mutation
Basal Cell Carcinoma
Ovarian Neoplasms
Melanoma
Neoplasms
Odds Ratio
Breast Neoplasms

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Genetics
  • Oncology
  • Genetics(clinical)

Cite this

Ginsburg, O. M., Kim-Sing, C., Foulkes, W. D., Ghadirian, P., Lynch, H. T., Sun, P., & Narod, S. A. (2010). BRCA1 and BRCA2 families and the risk of skin cancer. Familial Cancer, 9(4), 489-493. https://doi.org/10.1007/s10689-010-9377-y

BRCA1 and BRCA2 families and the risk of skin cancer. / Ginsburg, Ophira M.; Kim-Sing, Charmaine; Foulkes, William D.; Ghadirian, Parviz; Lynch, Henry T.; Sun, Ping; Narod, Steven A.

In: Familial Cancer, Vol. 9, No. 4, 12.2010, p. 489-493.

Research output: Contribution to journalArticle

Ginsburg, OM, Kim-Sing, C, Foulkes, WD, Ghadirian, P, Lynch, HT, Sun, P & Narod, SA 2010, 'BRCA1 and BRCA2 families and the risk of skin cancer', Familial Cancer, vol. 9, no. 4, pp. 489-493. https://doi.org/10.1007/s10689-010-9377-y
Ginsburg OM, Kim-Sing C, Foulkes WD, Ghadirian P, Lynch HT, Sun P et al. BRCA1 and BRCA2 families and the risk of skin cancer. Familial Cancer. 2010 Dec;9(4):489-493. https://doi.org/10.1007/s10689-010-9377-y
Ginsburg, Ophira M. ; Kim-Sing, Charmaine ; Foulkes, William D. ; Ghadirian, Parviz ; Lynch, Henry T. ; Sun, Ping ; Narod, Steven A. / BRCA1 and BRCA2 families and the risk of skin cancer. In: Familial Cancer. 2010 ; Vol. 9, No. 4. pp. 489-493.
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