Breast cancer and importance of zygosity determination in triplet sisters

Henry T. Lynch; Patrice Watson; Theresa Conway; Jane Lynch; Jeff Boyd

doi:10.1007/BF00713403

Breast cancer and importance of zygosity determination in triplet sisters

Henry T. Lynch, Patrice Watson, Theresa Conway, Jane Lynch, Jeff Boyd

Department of Preventive Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

This study is the first to examine the genetic risk in a breast cancer-prone family wherein two of three triplet sisters and their mother manifested breast cancer. The unaffected triplet, the proband, was found to be monozygotic with her deceased sister through DNA testing of tumor blocks and dizygotic to her living affected sister. Genetic counseling implications are discussed.

Original language	English (US)
Pages (from-to)	315-317
Number of pages	3
Journal	Breast Cancer Research and Treatment
Volume	36
Issue number	3
DOIs	https://doi.org/10.1007/BF00713403
State	Published - Jan 1 1995

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1007/BF00713403

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title = "Breast cancer and importance of zygosity determination in triplet sisters",

abstract = "This study is the first to examine the genetic risk in a breast cancer-prone family wherein two of three triplet sisters and their mother manifested breast cancer. The unaffected triplet, the proband, was found to be monozygotic with her deceased sister through DNA testing of tumor blocks and dizygotic to her living affected sister. Genetic counseling implications are discussed.",

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