Abstract
This study is the first to examine the genetic risk in a breast cancer-prone family wherein two of three triplet sisters and their mother manifested breast cancer. The unaffected triplet, the proband, was found to be monozygotic with her deceased sister through DNA testing of tumor blocks and dizygotic to her living affected sister. Genetic counseling implications are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 315-317 |
| Number of pages | 3 |
| Journal | Breast Cancer Research and Treatment |
| Volume | 36 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1995 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
Cite this
Breast cancer and importance of zygosity determination in triplet sisters. / Lynch, Henry T.; Watson, Patrice; Conway, Theresa; Lynch, Jane; Boyd, Jeff.
In: Breast Cancer Research and Treatment, Vol. 36, No. 3, 01.1995, p. 315-317.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Breast cancer and importance of zygosity determination in triplet sisters
AU - Lynch, Henry T.
AU - Watson, Patrice
AU - Conway, Theresa
AU - Lynch, Jane
AU - Boyd, Jeff
PY - 1995/1
Y1 - 1995/1
N2 - This study is the first to examine the genetic risk in a breast cancer-prone family wherein two of three triplet sisters and their mother manifested breast cancer. The unaffected triplet, the proband, was found to be monozygotic with her deceased sister through DNA testing of tumor blocks and dizygotic to her living affected sister. Genetic counseling implications are discussed.
AB - This study is the first to examine the genetic risk in a breast cancer-prone family wherein two of three triplet sisters and their mother manifested breast cancer. The unaffected triplet, the proband, was found to be monozygotic with her deceased sister through DNA testing of tumor blocks and dizygotic to her living affected sister. Genetic counseling implications are discussed.
UR - http://www.scopus.com/inward/record.url?scp=0029144684&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029144684&partnerID=8YFLogxK
U2 - 10.1007/BF00713403
DO - 10.1007/BF00713403
M3 - Article
C2 - 8573714
AN - SCOPUS:0029144684
VL - 36
SP - 315
EP - 317
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
SN - 0167-6806
IS - 3
ER -