Breast cancer diagnosis in a putative obligate gene carrier. A family study

Henry T. Lynch, Mary Lee Fitzsimmons, Judith Schreiman, Theresa Conway, Jane F. Lynch

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Hereditary breast cancer is common and accounts for about 8% of all breast cancer. It has a distinctive natural history characterized by early age of onset, excess bilaterality, and vertical transmission consonant with an autosomal dominant inheritance pattern. We describe an informative kindred wherein this knowledge was effectively applied, with resultant high yield: early breast cancer diagnosis in a mother who was a putative obligate gene carrier, and a contralateral breast cancer diagnosis in her daughter. A more intensive stance on breast cancer diagnosis must be employed in members of hereditary breast cancer kindreds who are judged to be at inordinately increased risk. Breast cancer control through application of genetic knowledge is readily achievable in the clinical practice setting.

Original languageEnglish
Pages (from-to)205-210
Number of pages6
JournalCancer Genetics and Cytogenetics
Volume36
Issue number2
DOIs
StatePublished - 1988

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Breast Neoplasms
Genes
Inheritance Patterns
Natural History
Early Detection of Cancer
Age of Onset

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Breast cancer diagnosis in a putative obligate gene carrier. A family study. / Lynch, Henry T.; Fitzsimmons, Mary Lee; Schreiman, Judith; Conway, Theresa; Lynch, Jane F.

In: Cancer Genetics and Cytogenetics, Vol. 36, No. 2, 1988, p. 205-210.

Research output: Contribution to journalArticle

Lynch, Henry T. ; Fitzsimmons, Mary Lee ; Schreiman, Judith ; Conway, Theresa ; Lynch, Jane F. / Breast cancer diagnosis in a putative obligate gene carrier. A family study. In: Cancer Genetics and Cytogenetics. 1988 ; Vol. 36, No. 2. pp. 205-210.
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