Abstract
Hereditary breast cancer is common and accounts for about 8% of all breast cancer. It has a distinctive natural history characterized by early age of onset, excess bilaterality, and vertical transmission consonant with an autosomal dominant inheritance pattern. We describe an informative kindred wherein this knowledge was effectively applied, with resultant high yield: early breast cancer diagnosis in a mother who was a putative obligate gene carrier, and a contralateral breast cancer diagnosis in her daughter. A more intensive stance on breast cancer diagnosis must be employed in members of hereditary breast cancer kindreds who are judged to be at inordinately increased risk. Breast cancer control through application of genetic knowledge is readily achievable in the clinical practice setting.
| Original language | English |
|---|---|
| Pages (from-to) | 205-210 |
| Number of pages | 6 |
| Journal | Cancer Genetics and Cytogenetics |
| Volume | 36 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1988 |
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All Science Journal Classification (ASJC) codes
- Cancer Research
- Genetics
- Molecular Biology
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Breast cancer diagnosis in a putative obligate gene carrier. A family study. / Lynch, Henry T.; Fitzsimmons, Mary Lee; Schreiman, Judith; Conway, Theresa; Lynch, Jane F.
In: Cancer Genetics and Cytogenetics, Vol. 36, No. 2, 1988, p. 205-210.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Breast cancer diagnosis in a putative obligate gene carrier. A family study
AU - Lynch, Henry T.
AU - Fitzsimmons, Mary Lee
AU - Schreiman, Judith
AU - Conway, Theresa
AU - Lynch, Jane F.
PY - 1988
Y1 - 1988
N2 - Hereditary breast cancer is common and accounts for about 8% of all breast cancer. It has a distinctive natural history characterized by early age of onset, excess bilaterality, and vertical transmission consonant with an autosomal dominant inheritance pattern. We describe an informative kindred wherein this knowledge was effectively applied, with resultant high yield: early breast cancer diagnosis in a mother who was a putative obligate gene carrier, and a contralateral breast cancer diagnosis in her daughter. A more intensive stance on breast cancer diagnosis must be employed in members of hereditary breast cancer kindreds who are judged to be at inordinately increased risk. Breast cancer control through application of genetic knowledge is readily achievable in the clinical practice setting.
AB - Hereditary breast cancer is common and accounts for about 8% of all breast cancer. It has a distinctive natural history characterized by early age of onset, excess bilaterality, and vertical transmission consonant with an autosomal dominant inheritance pattern. We describe an informative kindred wherein this knowledge was effectively applied, with resultant high yield: early breast cancer diagnosis in a mother who was a putative obligate gene carrier, and a contralateral breast cancer diagnosis in her daughter. A more intensive stance on breast cancer diagnosis must be employed in members of hereditary breast cancer kindreds who are judged to be at inordinately increased risk. Breast cancer control through application of genetic knowledge is readily achievable in the clinical practice setting.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024211926&partnerID=8YFLogxK
U2 - 10.1016/0165-4608(88)90147-1
DO - 10.1016/0165-4608(88)90147-1
M3 - Article
VL - 36
SP - 205
EP - 210
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 2
ER -