Breast cancer diagnosis in a putative obligate gene carrier. A family study

Henry T. Lynch, Mary Lee Fitzsimmons, Judith Schreiman, Theresa Conway, Jane F. Lynch

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Hereditary breast cancer is common and accounts for about 8% of all breast cancer. It has a distinctive natural history characterized by early age of onset, excess bilaterality, and vertical transmission consonant with an autosomal dominant inheritance pattern. We describe an informative kindred wherein this knowledge was effectively applied, with resultant high yield: early breast cancer diagnosis in a mother who was a putative obligate gene carrier, and a contralateral breast cancer diagnosis in her daughter. A more intensive stance on breast cancer diagnosis must be employed in members of hereditary breast cancer kindreds who are judged to be at inordinately increased risk. Breast cancer control through application of genetic knowledge is readily achievable in the clinical practice setting.

Original languageEnglish (US)
Pages (from-to)205-210
Number of pages6
JournalCancer Genetics and Cytogenetics
Issue number2
StatePublished - Dec 1988

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research


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