Breast cancer, genetics, and age at first pregnancy

Henry T. Lynch, W. A. Albano, M. A. Layton, W. J. Kimberling, J. F. Lynch

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Hereditary breast cancer shows a distinctive natural history characterised by an earlier age of onset, excess bilaterality, vertical transmission, heterogeneous tumour associations, and improved survival when compared to its sporadic counterpart. To date, very little attention has been given to interrelationships between breast cancer risk factors and genetics. In the general population, early age of first pregnancy has been generally accepted as protective against breast cancer. In addition, recent findings suggest that an early age of first pregnancy may be associated with an earlier age of breast cancer diagnosis. We studied the age at first pregnancy and age at onset of breast cancer among 162 females at 50% genetic risk, 72 of whom has already developed the disease. We then compared them to 154 consecutively ascertained breast cancer patients from the Creighton Cancer Center. In the hereditary subset (1) early first term pregnancy did not alter the frequency of breast cancer; (2) early age at first term pregnancy was not associated with an earlier age at cancer diagnosis; and (3) age of breast cancer onset in nulliparous females was not significantly lower than in females having at least one term pregnancy. We speculate, therefore, that in our hereditary population, pregnancy does not influence the natural history of breast cancer in the same way that it does in the population at large.

Original languageEnglish
Pages (from-to)96-98
Number of pages3
JournalJournal of Medical Genetics
Volume21
Issue number2
StatePublished - 1984

Fingerprint

Breast Neoplasms
Pregnancy
Age of Onset
Population
Neoplasms
Natural History
Survival

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Lynch, H. T., Albano, W. A., Layton, M. A., Kimberling, W. J., & Lynch, J. F. (1984). Breast cancer, genetics, and age at first pregnancy. Journal of Medical Genetics, 21(2), 96-98.

Breast cancer, genetics, and age at first pregnancy. / Lynch, Henry T.; Albano, W. A.; Layton, M. A.; Kimberling, W. J.; Lynch, J. F.

In: Journal of Medical Genetics, Vol. 21, No. 2, 1984, p. 96-98.

Research output: Contribution to journalArticle

Lynch, HT, Albano, WA, Layton, MA, Kimberling, WJ & Lynch, JF 1984, 'Breast cancer, genetics, and age at first pregnancy', Journal of Medical Genetics, vol. 21, no. 2, pp. 96-98.
Lynch HT, Albano WA, Layton MA, Kimberling WJ, Lynch JF. Breast cancer, genetics, and age at first pregnancy. Journal of Medical Genetics. 1984;21(2):96-98.
Lynch, Henry T. ; Albano, W. A. ; Layton, M. A. ; Kimberling, W. J. ; Lynch, J. F. / Breast cancer, genetics, and age at first pregnancy. In: Journal of Medical Genetics. 1984 ; Vol. 21, No. 2. pp. 96-98.
@article{a091cf5ea5844c248e28a597627be040,
title = "Breast cancer, genetics, and age at first pregnancy",
abstract = "Hereditary breast cancer shows a distinctive natural history characterised by an earlier age of onset, excess bilaterality, vertical transmission, heterogeneous tumour associations, and improved survival when compared to its sporadic counterpart. To date, very little attention has been given to interrelationships between breast cancer risk factors and genetics. In the general population, early age of first pregnancy has been generally accepted as protective against breast cancer. In addition, recent findings suggest that an early age of first pregnancy may be associated with an earlier age of breast cancer diagnosis. We studied the age at first pregnancy and age at onset of breast cancer among 162 females at 50{\%} genetic risk, 72 of whom has already developed the disease. We then compared them to 154 consecutively ascertained breast cancer patients from the Creighton Cancer Center. In the hereditary subset (1) early first term pregnancy did not alter the frequency of breast cancer; (2) early age at first term pregnancy was not associated with an earlier age at cancer diagnosis; and (3) age of breast cancer onset in nulliparous females was not significantly lower than in females having at least one term pregnancy. We speculate, therefore, that in our hereditary population, pregnancy does not influence the natural history of breast cancer in the same way that it does in the population at large.",
author = "Lynch, {Henry T.} and Albano, {W. A.} and Layton, {M. A.} and Kimberling, {W. J.} and Lynch, {J. F.}",
year = "1984",
language = "English",
volume = "21",
pages = "96--98",
journal = "Journal of Medical Genetics",
issn = "0022-2593",
publisher = "BMJ Publishing Group",
number = "2",

}

TY - JOUR

T1 - Breast cancer, genetics, and age at first pregnancy

AU - Lynch, Henry T.

AU - Albano, W. A.

AU - Layton, M. A.

AU - Kimberling, W. J.

AU - Lynch, J. F.

PY - 1984

Y1 - 1984

N2 - Hereditary breast cancer shows a distinctive natural history characterised by an earlier age of onset, excess bilaterality, vertical transmission, heterogeneous tumour associations, and improved survival when compared to its sporadic counterpart. To date, very little attention has been given to interrelationships between breast cancer risk factors and genetics. In the general population, early age of first pregnancy has been generally accepted as protective against breast cancer. In addition, recent findings suggest that an early age of first pregnancy may be associated with an earlier age of breast cancer diagnosis. We studied the age at first pregnancy and age at onset of breast cancer among 162 females at 50% genetic risk, 72 of whom has already developed the disease. We then compared them to 154 consecutively ascertained breast cancer patients from the Creighton Cancer Center. In the hereditary subset (1) early first term pregnancy did not alter the frequency of breast cancer; (2) early age at first term pregnancy was not associated with an earlier age at cancer diagnosis; and (3) age of breast cancer onset in nulliparous females was not significantly lower than in females having at least one term pregnancy. We speculate, therefore, that in our hereditary population, pregnancy does not influence the natural history of breast cancer in the same way that it does in the population at large.

AB - Hereditary breast cancer shows a distinctive natural history characterised by an earlier age of onset, excess bilaterality, vertical transmission, heterogeneous tumour associations, and improved survival when compared to its sporadic counterpart. To date, very little attention has been given to interrelationships between breast cancer risk factors and genetics. In the general population, early age of first pregnancy has been generally accepted as protective against breast cancer. In addition, recent findings suggest that an early age of first pregnancy may be associated with an earlier age of breast cancer diagnosis. We studied the age at first pregnancy and age at onset of breast cancer among 162 females at 50% genetic risk, 72 of whom has already developed the disease. We then compared them to 154 consecutively ascertained breast cancer patients from the Creighton Cancer Center. In the hereditary subset (1) early first term pregnancy did not alter the frequency of breast cancer; (2) early age at first term pregnancy was not associated with an earlier age at cancer diagnosis; and (3) age of breast cancer onset in nulliparous females was not significantly lower than in females having at least one term pregnancy. We speculate, therefore, that in our hereditary population, pregnancy does not influence the natural history of breast cancer in the same way that it does in the population at large.

UR - http://www.scopus.com/inward/record.url?scp=0021352732&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021352732&partnerID=8YFLogxK

M3 - Article

C2 - 6716424

AN - SCOPUS:0021352732

VL - 21

SP - 96

EP - 98

JO - Journal of Medical Genetics

JF - Journal of Medical Genetics

SN - 0022-2593

IS - 2

ER -