Abstract
Purpose: The purpose of this study was to estimate the extent of protection offered against breast cancer by prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations and to determine to what extent risk reduction varies with age at oophorectomy, age at diagnosis, and time elapsed since surgery. Patients and Methods: We analyzed 1,439 patients with breast cancer and 1,866 matched controls derived from a registry of BRCA1 and BRCA2 carriers. We estimated odds ratios (ORs) of breast cancer for having had a bilateral oophorectomy, using conditional logistic regression, matched for parity and for oral contraceptive use. Results: A previous history of oophorectomy was associated with a significant reduction in breast cancer risk of 56% for BRCA1 carriers (OR = 0.44; 95% CI, 0.29 to 0.66) and of 46% for BRCA2 carriers (OR = 0.57; 95% CI, 0.28 to 1.15). The risk reduction was greater if the oophorectomy was performed before age 40 (OR = 0.36; 95% Cl, 0.20 to 0.64 for BRCA1 carriers) than after age 40 (OR = 0.53; 95% CI, 0.30 to 0.91). The protective effect was evident for 15 years post-oophorectomy (OR = 0.39; 95% CI, 0.26 to 0.57). Conclusion: Oophorectomy is an effective means of reducing the risk of breast cancer in carriers of BRCA1 mutations. The data suggest oophorectomy is protective in BRCA2 carriers as well, but needs to be confirmed in other studies.
| Original language | English |
|---|---|
| Pages (from-to) | 7491-7496 |
| Number of pages | 6 |
| Journal | Journal of Clinical Oncology |
| Volume | 23 |
| Issue number | 30 |
| DOIs | |
| State | Published - 2005 |
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All Science Journal Classification (ASJC) codes
- Cancer Research
- Oncology
Cite this
Breast cancer risk following bilateral oophorectomy in BRCA1 and BRCA2 mutation carriers : An International Case-Control Study. / Eisen, Andrea; Lubinski, Jan; Klijn, Jan; Moller, Pal; Lynch, Henry T.; Offit, Kenneth; Weber, Barbara; Rebbeck, Tim; Neuhausen, Susan L.; Ghadirian, Parviz; Foulkes, William D.; Gershoni-Baruch, Ruth; Friedman, Eitan; Rennert, Gadi; Wagner, Teresa; Isaacs, Claudine; Kim-Sing, Charmaine; Ainsworth, Peter; Sun, Ping; Narod, Steven A.
In: Journal of Clinical Oncology, Vol. 23, No. 30, 2005, p. 7491-7496.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Breast cancer risk following bilateral oophorectomy in BRCA1 and BRCA2 mutation carriers
T2 - An International Case-Control Study
AU - Eisen, Andrea
AU - Lubinski, Jan
AU - Klijn, Jan
AU - Moller, Pal
AU - Lynch, Henry T.
AU - Offit, Kenneth
AU - Weber, Barbara
AU - Rebbeck, Tim
AU - Neuhausen, Susan L.
AU - Ghadirian, Parviz
AU - Foulkes, William D.
AU - Gershoni-Baruch, Ruth
AU - Friedman, Eitan
AU - Rennert, Gadi
AU - Wagner, Teresa
AU - Isaacs, Claudine
AU - Kim-Sing, Charmaine
AU - Ainsworth, Peter
AU - Sun, Ping
AU - Narod, Steven A.
PY - 2005
Y1 - 2005
N2 - Purpose: The purpose of this study was to estimate the extent of protection offered against breast cancer by prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations and to determine to what extent risk reduction varies with age at oophorectomy, age at diagnosis, and time elapsed since surgery. Patients and Methods: We analyzed 1,439 patients with breast cancer and 1,866 matched controls derived from a registry of BRCA1 and BRCA2 carriers. We estimated odds ratios (ORs) of breast cancer for having had a bilateral oophorectomy, using conditional logistic regression, matched for parity and for oral contraceptive use. Results: A previous history of oophorectomy was associated with a significant reduction in breast cancer risk of 56% for BRCA1 carriers (OR = 0.44; 95% CI, 0.29 to 0.66) and of 46% for BRCA2 carriers (OR = 0.57; 95% CI, 0.28 to 1.15). The risk reduction was greater if the oophorectomy was performed before age 40 (OR = 0.36; 95% Cl, 0.20 to 0.64 for BRCA1 carriers) than after age 40 (OR = 0.53; 95% CI, 0.30 to 0.91). The protective effect was evident for 15 years post-oophorectomy (OR = 0.39; 95% CI, 0.26 to 0.57). Conclusion: Oophorectomy is an effective means of reducing the risk of breast cancer in carriers of BRCA1 mutations. The data suggest oophorectomy is protective in BRCA2 carriers as well, but needs to be confirmed in other studies.
AB - Purpose: The purpose of this study was to estimate the extent of protection offered against breast cancer by prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations and to determine to what extent risk reduction varies with age at oophorectomy, age at diagnosis, and time elapsed since surgery. Patients and Methods: We analyzed 1,439 patients with breast cancer and 1,866 matched controls derived from a registry of BRCA1 and BRCA2 carriers. We estimated odds ratios (ORs) of breast cancer for having had a bilateral oophorectomy, using conditional logistic regression, matched for parity and for oral contraceptive use. Results: A previous history of oophorectomy was associated with a significant reduction in breast cancer risk of 56% for BRCA1 carriers (OR = 0.44; 95% CI, 0.29 to 0.66) and of 46% for BRCA2 carriers (OR = 0.57; 95% CI, 0.28 to 1.15). The risk reduction was greater if the oophorectomy was performed before age 40 (OR = 0.36; 95% Cl, 0.20 to 0.64 for BRCA1 carriers) than after age 40 (OR = 0.53; 95% CI, 0.30 to 0.91). The protective effect was evident for 15 years post-oophorectomy (OR = 0.39; 95% CI, 0.26 to 0.57). Conclusion: Oophorectomy is an effective means of reducing the risk of breast cancer in carriers of BRCA1 mutations. The data suggest oophorectomy is protective in BRCA2 carriers as well, but needs to be confirmed in other studies.
UR - http://www.scopus.com/inward/record.url?scp=29144522408&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=29144522408&partnerID=8YFLogxK
U2 - 10.1200/JCO.2004.00.7138
DO - 10.1200/JCO.2004.00.7138
M3 - Article
C2 - 16234515
AN - SCOPUS:29144522408
VL - 23
SP - 7491
EP - 7496
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
SN - 0732-183X
IS - 30
ER -