Breast cancer risk following bilateral oophorectomy in BRCA1 and BRCA2 mutation carriers: An International Case-Control Study

Andrea Eisen, Jan Lubinski, Jan Klijn, Pal Moller, Henry T. Lynch, Kenneth Offit, Barbara Weber, Tim Rebbeck, Susan L. Neuhausen, Parviz Ghadirian, William D. Foulkes, Ruth Gershoni-Baruch, Eitan Friedman, Gadi Rennert, Teresa Wagner, Claudine Isaacs, Charmaine Kim-Sing, Peter Ainsworth, Ping Sun, Steven A. Narod

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Abstract

Purpose: The purpose of this study was to estimate the extent of protection offered against breast cancer by prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations and to determine to what extent risk reduction varies with age at oophorectomy, age at diagnosis, and time elapsed since surgery. Patients and Methods: We analyzed 1,439 patients with breast cancer and 1,866 matched controls derived from a registry of BRCA1 and BRCA2 carriers. We estimated odds ratios (ORs) of breast cancer for having had a bilateral oophorectomy, using conditional logistic regression, matched for parity and for oral contraceptive use. Results: A previous history of oophorectomy was associated with a significant reduction in breast cancer risk of 56% for BRCA1 carriers (OR = 0.44; 95% CI, 0.29 to 0.66) and of 46% for BRCA2 carriers (OR = 0.57; 95% CI, 0.28 to 1.15). The risk reduction was greater if the oophorectomy was performed before age 40 (OR = 0.36; 95% Cl, 0.20 to 0.64 for BRCA1 carriers) than after age 40 (OR = 0.53; 95% CI, 0.30 to 0.91). The protective effect was evident for 15 years post-oophorectomy (OR = 0.39; 95% CI, 0.26 to 0.57). Conclusion: Oophorectomy is an effective means of reducing the risk of breast cancer in carriers of BRCA1 mutations. The data suggest oophorectomy is protective in BRCA2 carriers as well, but needs to be confirmed in other studies.

Original languageEnglish
Pages (from-to)7491-7496
Number of pages6
JournalJournal of Clinical Oncology
Volume23
Issue number30
DOIs
StatePublished - 2005

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Ovariectomy
Case-Control Studies
Breast Neoplasms
Mutation
Odds Ratio
Risk Reduction Behavior
Oral Contraceptives
Parity
Registries
Logistic Models

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

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Breast cancer risk following bilateral oophorectomy in BRCA1 and BRCA2 mutation carriers : An International Case-Control Study. / Eisen, Andrea; Lubinski, Jan; Klijn, Jan; Moller, Pal; Lynch, Henry T.; Offit, Kenneth; Weber, Barbara; Rebbeck, Tim; Neuhausen, Susan L.; Ghadirian, Parviz; Foulkes, William D.; Gershoni-Baruch, Ruth; Friedman, Eitan; Rennert, Gadi; Wagner, Teresa; Isaacs, Claudine; Kim-Sing, Charmaine; Ainsworth, Peter; Sun, Ping; Narod, Steven A.

In: Journal of Clinical Oncology, Vol. 23, No. 30, 2005, p. 7491-7496.

Research output: Contribution to journalArticle

Eisen, A, Lubinski, J, Klijn, J, Moller, P, Lynch, HT, Offit, K, Weber, B, Rebbeck, T, Neuhausen, SL, Ghadirian, P, Foulkes, WD, Gershoni-Baruch, R, Friedman, E, Rennert, G, Wagner, T, Isaacs, C, Kim-Sing, C, Ainsworth, P, Sun, P & Narod, SA 2005, 'Breast cancer risk following bilateral oophorectomy in BRCA1 and BRCA2 mutation carriers: An International Case-Control Study', Journal of Clinical Oncology, vol. 23, no. 30, pp. 7491-7496. https://doi.org/10.1200/JCO.2004.00.7138
Eisen, Andrea ; Lubinski, Jan ; Klijn, Jan ; Moller, Pal ; Lynch, Henry T. ; Offit, Kenneth ; Weber, Barbara ; Rebbeck, Tim ; Neuhausen, Susan L. ; Ghadirian, Parviz ; Foulkes, William D. ; Gershoni-Baruch, Ruth ; Friedman, Eitan ; Rennert, Gadi ; Wagner, Teresa ; Isaacs, Claudine ; Kim-Sing, Charmaine ; Ainsworth, Peter ; Sun, Ping ; Narod, Steven A. / Breast cancer risk following bilateral oophorectomy in BRCA1 and BRCA2 mutation carriers : An International Case-Control Study. In: Journal of Clinical Oncology. 2005 ; Vol. 23, No. 30. pp. 7491-7496.
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abstract = "Purpose: The purpose of this study was to estimate the extent of protection offered against breast cancer by prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations and to determine to what extent risk reduction varies with age at oophorectomy, age at diagnosis, and time elapsed since surgery. Patients and Methods: We analyzed 1,439 patients with breast cancer and 1,866 matched controls derived from a registry of BRCA1 and BRCA2 carriers. We estimated odds ratios (ORs) of breast cancer for having had a bilateral oophorectomy, using conditional logistic regression, matched for parity and for oral contraceptive use. Results: A previous history of oophorectomy was associated with a significant reduction in breast cancer risk of 56{\%} for BRCA1 carriers (OR = 0.44; 95{\%} CI, 0.29 to 0.66) and of 46{\%} for BRCA2 carriers (OR = 0.57; 95{\%} CI, 0.28 to 1.15). The risk reduction was greater if the oophorectomy was performed before age 40 (OR = 0.36; 95{\%} Cl, 0.20 to 0.64 for BRCA1 carriers) than after age 40 (OR = 0.53; 95{\%} CI, 0.30 to 0.91). The protective effect was evident for 15 years post-oophorectomy (OR = 0.39; 95{\%} CI, 0.26 to 0.57). Conclusion: Oophorectomy is an effective means of reducing the risk of breast cancer in carriers of BRCA1 mutations. The data suggest oophorectomy is protective in BRCA2 carriers as well, but needs to be confirmed in other studies.",
author = "Andrea Eisen and Jan Lubinski and Jan Klijn and Pal Moller and Lynch, {Henry T.} and Kenneth Offit and Barbara Weber and Tim Rebbeck and Neuhausen, {Susan L.} and Parviz Ghadirian and Foulkes, {William D.} and Ruth Gershoni-Baruch and Eitan Friedman and Gadi Rennert and Teresa Wagner and Claudine Isaacs and Charmaine Kim-Sing and Peter Ainsworth and Ping Sun and Narod, {Steven A.}",
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TY - JOUR

T1 - Breast cancer risk following bilateral oophorectomy in BRCA1 and BRCA2 mutation carriers

T2 - An International Case-Control Study

AU - Eisen, Andrea

AU - Lubinski, Jan

AU - Klijn, Jan

AU - Moller, Pal

AU - Lynch, Henry T.

AU - Offit, Kenneth

AU - Weber, Barbara

AU - Rebbeck, Tim

AU - Neuhausen, Susan L.

AU - Ghadirian, Parviz

AU - Foulkes, William D.

AU - Gershoni-Baruch, Ruth

AU - Friedman, Eitan

AU - Rennert, Gadi

AU - Wagner, Teresa

AU - Isaacs, Claudine

AU - Kim-Sing, Charmaine

AU - Ainsworth, Peter

AU - Sun, Ping

AU - Narod, Steven A.

PY - 2005

Y1 - 2005

N2 - Purpose: The purpose of this study was to estimate the extent of protection offered against breast cancer by prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations and to determine to what extent risk reduction varies with age at oophorectomy, age at diagnosis, and time elapsed since surgery. Patients and Methods: We analyzed 1,439 patients with breast cancer and 1,866 matched controls derived from a registry of BRCA1 and BRCA2 carriers. We estimated odds ratios (ORs) of breast cancer for having had a bilateral oophorectomy, using conditional logistic regression, matched for parity and for oral contraceptive use. Results: A previous history of oophorectomy was associated with a significant reduction in breast cancer risk of 56% for BRCA1 carriers (OR = 0.44; 95% CI, 0.29 to 0.66) and of 46% for BRCA2 carriers (OR = 0.57; 95% CI, 0.28 to 1.15). The risk reduction was greater if the oophorectomy was performed before age 40 (OR = 0.36; 95% Cl, 0.20 to 0.64 for BRCA1 carriers) than after age 40 (OR = 0.53; 95% CI, 0.30 to 0.91). The protective effect was evident for 15 years post-oophorectomy (OR = 0.39; 95% CI, 0.26 to 0.57). Conclusion: Oophorectomy is an effective means of reducing the risk of breast cancer in carriers of BRCA1 mutations. The data suggest oophorectomy is protective in BRCA2 carriers as well, but needs to be confirmed in other studies.

AB - Purpose: The purpose of this study was to estimate the extent of protection offered against breast cancer by prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations and to determine to what extent risk reduction varies with age at oophorectomy, age at diagnosis, and time elapsed since surgery. Patients and Methods: We analyzed 1,439 patients with breast cancer and 1,866 matched controls derived from a registry of BRCA1 and BRCA2 carriers. We estimated odds ratios (ORs) of breast cancer for having had a bilateral oophorectomy, using conditional logistic regression, matched for parity and for oral contraceptive use. Results: A previous history of oophorectomy was associated with a significant reduction in breast cancer risk of 56% for BRCA1 carriers (OR = 0.44; 95% CI, 0.29 to 0.66) and of 46% for BRCA2 carriers (OR = 0.57; 95% CI, 0.28 to 1.15). The risk reduction was greater if the oophorectomy was performed before age 40 (OR = 0.36; 95% Cl, 0.20 to 0.64 for BRCA1 carriers) than after age 40 (OR = 0.53; 95% CI, 0.30 to 0.91). The protective effect was evident for 15 years post-oophorectomy (OR = 0.39; 95% CI, 0.26 to 0.57). Conclusion: Oophorectomy is an effective means of reducing the risk of breast cancer in carriers of BRCA1 mutations. The data suggest oophorectomy is protective in BRCA2 carriers as well, but needs to be confirmed in other studies.

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