Breast-feeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers

H. Jernström, J. Lubinski, Henry T. Lynch, P. Ghadirian, S. Neuhausen, C. Isaacs, B. L. Weber, D. Horsman, B. Rosen, W. D. Foulkes, E. Friedman, R. Gershoni-Baruch, P. Ainsworth, M. Daly, J. Garber, H. Olsson, P. Sun, Steven A. Narod

Research output: Contribution to journalArticle

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Abstract

Background: Several studies have reported that the risk of breast cancer decreases with increasing duration of breast-feeding. Whether breast-feeding is associated with a reduced risk of hereditary breast cancer in women who carry deleterious BRCA1 and BRCA2 mutations is currently unknown. Methods: We conducted a case-control study of women with deleterious mutations in either the BRCA1 or the BRCA2 gene. Study participants, drawn from an international cohort, were matched on the basis of BRCA mutation (BRCA1 [n = 685] or BRCA2 [n = 280]), year of birth (±2 years), and country of residence. The study involved 965 case subjects diagnosed with breast cancer and 965 control subjects who had no history of breast or ovarian cancer. Information on pregnancies and breast-feeding practices was derived from a questionnaire administered to the women during the course of genetic counseling. Conditional logistic regression analyses were used to estimate odds ratios (ORs) for the risk of breast cancer. All statistical tests were two-sided. Results: Among women with BRCA1 mutations, the mean total duration of breast-feeding was statistically significantly shorter for case subjects than for control subjects (6.0 versus 8.7 months, respectively; mean difference = 2.7 months, 95% confidence interval [CI] = 1.4 to 4.0; Ptrend

Original languageEnglish
Pages (from-to)1094-1098
Number of pages5
JournalJournal of the National Cancer Institute
Volume96
Issue number14
StatePublished - Jul 21 2004

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Breast Feeding
Breast Neoplasms
Mutation
BRCA2 Gene
Genetic Counseling
Ovarian Neoplasms
Case-Control Studies
Logistic Models
Odds Ratio
Regression Analysis
Parturition
Confidence Intervals
Pregnancy

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Jernström, H., Lubinski, J., Lynch, H. T., Ghadirian, P., Neuhausen, S., Isaacs, C., ... Narod, S. A. (2004). Breast-feeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. Journal of the National Cancer Institute, 96(14), 1094-1098.

Breast-feeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. / Jernström, H.; Lubinski, J.; Lynch, Henry T.; Ghadirian, P.; Neuhausen, S.; Isaacs, C.; Weber, B. L.; Horsman, D.; Rosen, B.; Foulkes, W. D.; Friedman, E.; Gershoni-Baruch, R.; Ainsworth, P.; Daly, M.; Garber, J.; Olsson, H.; Sun, P.; Narod, Steven A.

In: Journal of the National Cancer Institute, Vol. 96, No. 14, 21.07.2004, p. 1094-1098.

Research output: Contribution to journalArticle

Jernström, H, Lubinski, J, Lynch, HT, Ghadirian, P, Neuhausen, S, Isaacs, C, Weber, BL, Horsman, D, Rosen, B, Foulkes, WD, Friedman, E, Gershoni-Baruch, R, Ainsworth, P, Daly, M, Garber, J, Olsson, H, Sun, P & Narod, SA 2004, 'Breast-feeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers', Journal of the National Cancer Institute, vol. 96, no. 14, pp. 1094-1098.
Jernström H, Lubinski J, Lynch HT, Ghadirian P, Neuhausen S, Isaacs C et al. Breast-feeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. Journal of the National Cancer Institute. 2004 Jul 21;96(14):1094-1098.
Jernström, H. ; Lubinski, J. ; Lynch, Henry T. ; Ghadirian, P. ; Neuhausen, S. ; Isaacs, C. ; Weber, B. L. ; Horsman, D. ; Rosen, B. ; Foulkes, W. D. ; Friedman, E. ; Gershoni-Baruch, R. ; Ainsworth, P. ; Daly, M. ; Garber, J. ; Olsson, H. ; Sun, P. ; Narod, Steven A. / Breast-feeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. In: Journal of the National Cancer Institute. 2004 ; Vol. 96, No. 14. pp. 1094-1098.
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abstract = "Background: Several studies have reported that the risk of breast cancer decreases with increasing duration of breast-feeding. Whether breast-feeding is associated with a reduced risk of hereditary breast cancer in women who carry deleterious BRCA1 and BRCA2 mutations is currently unknown. Methods: We conducted a case-control study of women with deleterious mutations in either the BRCA1 or the BRCA2 gene. Study participants, drawn from an international cohort, were matched on the basis of BRCA mutation (BRCA1 [n = 685] or BRCA2 [n = 280]), year of birth (±2 years), and country of residence. The study involved 965 case subjects diagnosed with breast cancer and 965 control subjects who had no history of breast or ovarian cancer. Information on pregnancies and breast-feeding practices was derived from a questionnaire administered to the women during the course of genetic counseling. Conditional logistic regression analyses were used to estimate odds ratios (ORs) for the risk of breast cancer. All statistical tests were two-sided. Results: Among women with BRCA1 mutations, the mean total duration of breast-feeding was statistically significantly shorter for case subjects than for control subjects (6.0 versus 8.7 months, respectively; mean difference = 2.7 months, 95{\%} confidence interval [CI] = 1.4 to 4.0; Ptrend",
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AU - Neuhausen, S.

AU - Isaacs, C.

AU - Weber, B. L.

AU - Horsman, D.

AU - Rosen, B.

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