Broncial reactivity pattern in nonasthmatic parents of asthmatics

R. J. Hopp, Againdra K. Bewtra, R. Biven, N. M. Nair, R. G. Townley

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Genetic mechanisms have been proposed to explain the presence of asthma in families. A methacholine challenge can identify individuals with bronchial reactivity (a hallmark of asthma). It may then be possible to determine whether the presence of non-specific bronchial reactivity, as detected by a methacholine response, has potential as a genetic marker. Thirty-one non-asthmatic parent pairs of asthmatic children were selected from asthma (AF) families enrolled in a Natural History of Asthma study. Parent pairs were chosen if both gave negative responses to a modified National Heart, Lung and Blood Institute questionnaire on asthma. The methacholine response of these parents of asthmatic children had a bimodal distribution. These results show that the methacholine response can mark bronchial reactivity without the presence of clinical asthma and that a familial component of bronchial reactivity exists which may be transmitted from one generation to the next.

Original languageEnglish
Pages (from-to)184-186
Number of pages3
JournalAnnals of Allergy
Volume61
Issue number3
StatePublished - 1988

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Asthma
Methacholine Chloride
Parents
National Heart, Lung, and Blood Institute (U.S.)
Genetic Markers

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy

Cite this

Hopp, R. J., Bewtra, A. K., Biven, R., Nair, N. M., & Townley, R. G. (1988). Broncial reactivity pattern in nonasthmatic parents of asthmatics. Annals of Allergy, 61(3), 184-186.

Broncial reactivity pattern in nonasthmatic parents of asthmatics. / Hopp, R. J.; Bewtra, Againdra K.; Biven, R.; Nair, N. M.; Townley, R. G.

In: Annals of Allergy, Vol. 61, No. 3, 1988, p. 184-186.

Research output: Contribution to journalArticle

Hopp, RJ, Bewtra, AK, Biven, R, Nair, NM & Townley, RG 1988, 'Broncial reactivity pattern in nonasthmatic parents of asthmatics', Annals of Allergy, vol. 61, no. 3, pp. 184-186.
Hopp RJ, Bewtra AK, Biven R, Nair NM, Townley RG. Broncial reactivity pattern in nonasthmatic parents of asthmatics. Annals of Allergy. 1988;61(3):184-186.
Hopp, R. J. ; Bewtra, Againdra K. ; Biven, R. ; Nair, N. M. ; Townley, R. G. / Broncial reactivity pattern in nonasthmatic parents of asthmatics. In: Annals of Allergy. 1988 ; Vol. 61, No. 3. pp. 184-186.
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