Budesonide delivered by Turbuhaler is effective in a dose-dependent fashion when used in the treatment of adult patients with chronic asthma

William W. Busse, Paul Chervinsky, John Condemi, William R. Lumry, Thomas L. Petty, Stephen Rennard, Robert G. Townley

Research output: Contribution to journalArticle

172 Citations (Scopus)

Abstract

Background: Airway inflammation is a hallmark of asthma, therefore current treatment recommendations include the use of inhaled glucocorticosteroids (GCS). However, there is little evidence that the effects of inhaled GCS are dose dependent. Objectives: The objective of this study was to assess the efficacy and safety of a second-generation GCS, budesonide, delivered by Turbuhaler, in adults with chronic asthma. Methods: In a 12-week, randomized, double-blind, multi-center, parallel-group study, 473 subjects 18 to 70 years of age received either placebo or budesonide (200, 400, 800, or 1600 μg total daily dose) administered twice daily. Primary efficacy end points were mean change from baseline for FEV1 and morning peak expiratory flow. Safety was assessed by reported adverse events and by a cosyntropin-stimulation test. Results: The mean baseline FEV1 was 63% to 66% of predicted normal value between groups. All doses of budesonide were more effective than placebo (p <0.001). The mean changes in morning peak expiratory flow were 12, 22, 27, and 30 L/min in the 200, 400, 800, and 1600 μg budesonide total daily dose groups, respectively, and -27 L/min for the placebo group. A statistically significant dose-response effect for the mean change from baseline over the 12-week study was seen for both morning peak expiratory flow and FEV1. Budesonide-treated subjects also demonstrated significant reduction in asthma symptoms and bronchodilator use compared with placebo. There were no clinically significant differences in treatment- related adverse experiences among groups. Conclusions: Budesonide administered by Turbuhaler exhibited a dose response and was effective at low doses. It was well tolerated and significantly more effective than placebo.

Original languageEnglish
Pages (from-to)457-463
Number of pages7
JournalJournal of Allergy and Clinical Immunology
Volume101
Issue number4 I
DOIs
StatePublished - 1998
Externally publishedYes

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Budesonide
Asthma
Placebos
Therapeutics
Cosyntropin
Safety
Bronchodilator Agents
Reference Values
Inflammation

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Budesonide delivered by Turbuhaler is effective in a dose-dependent fashion when used in the treatment of adult patients with chronic asthma. / Busse, William W.; Chervinsky, Paul; Condemi, John; Lumry, William R.; Petty, Thomas L.; Rennard, Stephen; Townley, Robert G.

In: Journal of Allergy and Clinical Immunology, Vol. 101, No. 4 I, 1998, p. 457-463.

Research output: Contribution to journalArticle

Busse, William W. ; Chervinsky, Paul ; Condemi, John ; Lumry, William R. ; Petty, Thomas L. ; Rennard, Stephen ; Townley, Robert G. / Budesonide delivered by Turbuhaler is effective in a dose-dependent fashion when used in the treatment of adult patients with chronic asthma. In: Journal of Allergy and Clinical Immunology. 1998 ; Vol. 101, No. 4 I. pp. 457-463.
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abstract = "Background: Airway inflammation is a hallmark of asthma, therefore current treatment recommendations include the use of inhaled glucocorticosteroids (GCS). However, there is little evidence that the effects of inhaled GCS are dose dependent. Objectives: The objective of this study was to assess the efficacy and safety of a second-generation GCS, budesonide, delivered by Turbuhaler, in adults with chronic asthma. Methods: In a 12-week, randomized, double-blind, multi-center, parallel-group study, 473 subjects 18 to 70 years of age received either placebo or budesonide (200, 400, 800, or 1600 μg total daily dose) administered twice daily. Primary efficacy end points were mean change from baseline for FEV1 and morning peak expiratory flow. Safety was assessed by reported adverse events and by a cosyntropin-stimulation test. Results: The mean baseline FEV1 was 63{\%} to 66{\%} of predicted normal value between groups. All doses of budesonide were more effective than placebo (p <0.001). The mean changes in morning peak expiratory flow were 12, 22, 27, and 30 L/min in the 200, 400, 800, and 1600 μg budesonide total daily dose groups, respectively, and -27 L/min for the placebo group. A statistically significant dose-response effect for the mean change from baseline over the 12-week study was seen for both morning peak expiratory flow and FEV1. Budesonide-treated subjects also demonstrated significant reduction in asthma symptoms and bronchodilator use compared with placebo. There were no clinically significant differences in treatment- related adverse experiences among groups. Conclusions: Budesonide administered by Turbuhaler exhibited a dose response and was effective at low doses. It was well tolerated and significantly more effective than placebo.",
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