C-reactive protein levels are influenced by common IL-1 gene variations

Peter Berger, Joseph P. McConnell, Martha E. Nunn, Kenneth S. Kornman, Julian Sorrell, Katherine Stephenson, Gordon W. Duff

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

Elevated markers of systemic inflammation are associated with the development of acute coronary syndromes, but there is no current explanation for increased inflammation in overtly healthy individuals. The influence of genetic control of the inflammatory response on the observed variability is unknown. We studied the frequency of four polymorphisms in interleukin (IL) 1 genes, known to modulate inflammation, in 454 individuals undergoing coronary angiography and analysed their influence on plasma C-reactive protein (CRP) and fibrinogen levels. Females and smokers had higher levels of CRP than males (Π=0.001) and non-smokers (Π=0.001). Patients with genotype 2.2 for the IL-1B(+3954) polymorphism had twice the median CRP levels of patients who were genotype 1.1 (4.33 vs 2.01 mg/l; P=0.001). Patients with genotype 1.2 or 2.2 at the IL-1A(+4845) polymorphism also had higher median CRP (2.92 vs 2.05 mg/l, Π=0.023). In multivariate analyses, CRP levels remained significantly associated with IL-1 polymorphisms after adjustment for smoking, gender and age. Fibrinogen levels had similar associations with the IL-1 genotypes. These data indicate that IL-1 gene polymorphisms known to affect the inflammatory response are highly related to plasma levels of CRP and fibrinogen in patients referred for coronary angiography.

Original languageEnglish
Pages (from-to)171-174
Number of pages4
JournalCytokine
Volume17
Issue number4
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Interleukin-1
C-Reactive Protein
Polymorphism
Genes
Genotype
Fibrinogen
Angiography
Interleukins
Inflammation
Coronary Angiography
Plasmas
Acute Coronary Syndrome
Blood Proteins
Multivariate Analysis
Smoking

All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Molecular Biology
  • Immunology
  • Immunology and Allergy

Cite this

Berger, P., McConnell, J. P., Nunn, M. E., Kornman, K. S., Sorrell, J., Stephenson, K., & Duff, G. W. (2002). C-reactive protein levels are influenced by common IL-1 gene variations. Cytokine, 17(4), 171-174. https://doi.org/10.1006/cyto.2001.0974

C-reactive protein levels are influenced by common IL-1 gene variations. / Berger, Peter; McConnell, Joseph P.; Nunn, Martha E.; Kornman, Kenneth S.; Sorrell, Julian; Stephenson, Katherine; Duff, Gordon W.

In: Cytokine, Vol. 17, No. 4, 2002, p. 171-174.

Research output: Contribution to journalArticle

Berger, P, McConnell, JP, Nunn, ME, Kornman, KS, Sorrell, J, Stephenson, K & Duff, GW 2002, 'C-reactive protein levels are influenced by common IL-1 gene variations', Cytokine, vol. 17, no. 4, pp. 171-174. https://doi.org/10.1006/cyto.2001.0974
Berger P, McConnell JP, Nunn ME, Kornman KS, Sorrell J, Stephenson K et al. C-reactive protein levels are influenced by common IL-1 gene variations. Cytokine. 2002;17(4):171-174. https://doi.org/10.1006/cyto.2001.0974
Berger, Peter ; McConnell, Joseph P. ; Nunn, Martha E. ; Kornman, Kenneth S. ; Sorrell, Julian ; Stephenson, Katherine ; Duff, Gordon W. / C-reactive protein levels are influenced by common IL-1 gene variations. In: Cytokine. 2002 ; Vol. 17, No. 4. pp. 171-174.
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