CA repeat polymorphism of the TNFR2 gene is not associated with bone mineral density in two independent Caucasian populations

Qing Yang Huang, Hui Shen, Hong Yi Deng, Theresa Conway, Leo Elze, K. Michael Davies, Robert R. Recker, Hong Wen Deng

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Osteoporosis has a strong genetic component, but the genes involved are poorly defined. Genome-wide scans in multiple populations have identified chromosome 1p36 as one region linked to bone mineral density (BMD). The tumor necrosis factor receptor 2 (TNFR2) at 1p36 is a positional and functional candidate gene in osteoporosis. In this study, we conducted linkage and association tests between the CA repeat polymorphism of the TNFR2 gene and BMD in two large independent samples using the quantitative transmission disequilibrium test (QTDT) program. The first group of subjects was composed of 1836 individuals from 79 multigeneration pedigrees. The second group was a randomly ascertained set of 636 individuals from 157 nuclear families. We found no evidence of association or linkage for spine or hip BMD in the samples of the multigenerational pedigrees or nuclear families. Through testing for association and for linkage, our data do not support the TNFR2 gene as a QTL underlying hip or spine BMD variation in our Caucasian populations.

Original languageEnglish
Pages (from-to)132-137
Number of pages6
JournalJournal of Bone and Mineral Metabolism
Volume24
Issue number2
DOIs
StatePublished - Mar 2006

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Receptors, Tumor Necrosis Factor, Type II
Bone Density
Pedigree
Nuclear Family
Population
Genes
Osteoporosis
Spine
Pelvic Bones
Gene Components
Information Storage and Retrieval
Hip
Chromosomes
Genome

All Science Journal Classification (ASJC) codes

  • Endocrinology

Cite this

CA repeat polymorphism of the TNFR2 gene is not associated with bone mineral density in two independent Caucasian populations. / Huang, Qing Yang; Shen, Hui; Deng, Hong Yi; Conway, Theresa; Elze, Leo; Davies, K. Michael; Recker, Robert R.; Deng, Hong Wen.

In: Journal of Bone and Mineral Metabolism, Vol. 24, No. 2, 03.2006, p. 132-137.

Research output: Contribution to journalArticle

Huang, Qing Yang ; Shen, Hui ; Deng, Hong Yi ; Conway, Theresa ; Elze, Leo ; Davies, K. Michael ; Recker, Robert R. ; Deng, Hong Wen. / CA repeat polymorphism of the TNFR2 gene is not associated with bone mineral density in two independent Caucasian populations. In: Journal of Bone and Mineral Metabolism. 2006 ; Vol. 24, No. 2. pp. 132-137.
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AU - Recker, Robert R.

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