Abstract
Calcitonin gene-related peptide (CGRP) is a member of the calcitonin family of peptides. Other members are calcitonin, a 32-amino acid residue peptide that reduces bone resorption; amylin, a 37-amino acid residue peptide that reduces food intake; and adrenomedullin, a potent vasodilator, 52-amino acid residues long. As its name implies, CGRP is produced by tissue-specific alternate splicing of the calcitonin gene. In human and rat, this form is designated alpha- and a second form exists called beta-CGRP, which is derived from a different, noncalcitonin gene. Both forms of CGRP contain 37-amino acid residues with a disulphide bridge between positions 2 and 7, and a C-terminal phenylalanylamide residue. Alpha-CGRP differs from the beta-form by one amino acid residue in rat and three amino residues acids in human ....
| Original language | English |
|---|---|
| Title of host publication | xPharm: The Comprehensive Pharmacology Reference |
| Publisher | Elsevier Inc. |
| Pages | 1-4 |
| Number of pages | 4 |
| ISBN (Print) | 9780080552323 |
| DOIs | |
| State | Published - 2011 |
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All Science Journal Classification (ASJC) codes
- Pharmacology, Toxicology and Pharmaceutics(all)
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Calcitonin gene-related peptide. / Abel, Peter W.; Smith, D. David.
xPharm: The Comprehensive Pharmacology Reference. Elsevier Inc., 2011. p. 1-4.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Calcitonin gene-related peptide
AU - Abel, Peter W.
AU - Smith, D. David
PY - 2011
Y1 - 2011
N2 - Calcitonin gene-related peptide (CGRP) is a member of the calcitonin family of peptides. Other members are calcitonin, a 32-amino acid residue peptide that reduces bone resorption; amylin, a 37-amino acid residue peptide that reduces food intake; and adrenomedullin, a potent vasodilator, 52-amino acid residues long. As its name implies, CGRP is produced by tissue-specific alternate splicing of the calcitonin gene. In human and rat, this form is designated alpha- and a second form exists called beta-CGRP, which is derived from a different, noncalcitonin gene. Both forms of CGRP contain 37-amino acid residues with a disulphide bridge between positions 2 and 7, and a C-terminal phenylalanylamide residue. Alpha-CGRP differs from the beta-form by one amino acid residue in rat and three amino residues acids in human ....
AB - Calcitonin gene-related peptide (CGRP) is a member of the calcitonin family of peptides. Other members are calcitonin, a 32-amino acid residue peptide that reduces bone resorption; amylin, a 37-amino acid residue peptide that reduces food intake; and adrenomedullin, a potent vasodilator, 52-amino acid residues long. As its name implies, CGRP is produced by tissue-specific alternate splicing of the calcitonin gene. In human and rat, this form is designated alpha- and a second form exists called beta-CGRP, which is derived from a different, noncalcitonin gene. Both forms of CGRP contain 37-amino acid residues with a disulphide bridge between positions 2 and 7, and a C-terminal phenylalanylamide residue. Alpha-CGRP differs from the beta-form by one amino acid residue in rat and three amino residues acids in human ....
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U2 - 10.1016/B978-008055232-3.61434-5
DO - 10.1016/B978-008055232-3.61434-5
M3 - Chapter
SN - 9780080552323
SP - 1
EP - 4
BT - xPharm: The Comprehensive Pharmacology Reference
PB - Elsevier Inc.
ER -