Calcitonin gene-related peptide

Peter W. Abel, D. David Smith

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Calcitonin gene-related peptide (CGRP) is a member of the calcitonin family of peptides. Other members are calcitonin, a 32-amino acid residue peptide that reduces bone resorption; amylin, a 37-amino acid residue peptide that reduces food intake; and adrenomedullin, a potent vasodilator, 52-amino acid residues long. As its name implies, CGRP is produced by tissue-specific alternate splicing of the calcitonin gene. In human and rat, this form is designated alpha- and a second form exists called beta-CGRP, which is derived from a different, noncalcitonin gene. Both forms of CGRP contain 37-amino acid residues with a disulphide bridge between positions 2 and 7, and a C-terminal phenylalanylamide residue. Alpha-CGRP differs from the beta-form by one amino acid residue in rat and three amino residues acids in human ....

Original languageEnglish
Title of host publicationxPharm: The Comprehensive Pharmacology Reference
PublisherElsevier Inc.
Pages1-4
Number of pages4
ISBN (Print)9780080552323
DOIs
Publication statusPublished - 2011

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All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Abel, P. W., & Smith, D. D. (2011). Calcitonin gene-related peptide. In xPharm: The Comprehensive Pharmacology Reference (pp. 1-4). Elsevier Inc.. https://doi.org/10.1016/B978-008055232-3.61434-5