Abstract
Calcitonin gene-related peptide (CGRP) is a member of the calcitonin family of peptides. Other members are calcitonin, a 32-amino acid residue peptide that reduces bone resorption; amylin, a 37-amino acid residue peptide that reduces food intake; and adrenomedullin, a potent vasodilator, 52-amino acid residues long. As its name implies, CGRP is produced by tissue-specific alternate splicing of the calcitonin gene. In human and rat, this form is designated alpha- and a second form exists called beta-CGRP, which is derived from a different, noncalcitonin gene. Both forms of CGRP contain 37-amino acid residues with a disulphide bridge between positions 2 and 7, and a C-terminal phenylalanylamide residue. Alpha-CGRP differs from the beta-form by one amino acid residue in rat and three amino residues acids in human ....
Original language | English (US) |
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Title of host publication | xPharm |
Subtitle of host publication | The Comprehensive Pharmacology Reference |
Publisher | Elsevier Inc. |
Pages | 1-4 |
Number of pages | 4 |
ISBN (Print) | 9780080552323 |
DOIs | |
State | Published - Jan 1 2007 |
All Science Journal Classification (ASJC) codes
- Pharmacology, Toxicology and Pharmaceutics(all)