Calcitonin gene-related peptide

Peter Abel, D. David Smith

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Calcitonin gene-related peptide (CGRP) is a member of the calcitonin family of peptides. Other members are calcitonin, a 32-amino acid residue peptide that reduces bone resorption; amylin, a 37-amino acid residue peptide that reduces food intake; and adrenomedullin, a potent vasodilator, 52-amino acid residues long. As its name implies, CGRP is produced by tissue-specific alternate splicing of the calcitonin gene. In human and rat, this form is designated alpha- and a second form exists called beta-CGRP, which is derived from a different, noncalcitonin gene. Both forms of CGRP contain 37-amino acid residues with a disulphide bridge between positions 2 and 7, and a C-terminal phenylalanylamide residue. Alpha-CGRP differs from the beta-form by one amino acid residue in rat and three amino residues acids in human ....

Original languageEnglish (US)
Title of host publicationxPharm
Subtitle of host publicationThe Comprehensive Pharmacology Reference
PublisherElsevier Inc.
Pages1-4
Number of pages4
ISBN (Print)9780080552323
DOIs
StatePublished - Jan 1 2007

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Abel, P., & Smith, D. D. (2007). Calcitonin gene-related peptide. In xPharm: The Comprehensive Pharmacology Reference (pp. 1-4). Elsevier Inc.. https://doi.org/10.1016/B978-008055232-3.61434-5