Calcium

Robert P. Heaney

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Calcium is the principal cation of bone, making up almost 20% of its dry weight. Bone constitutes a very large nutrient reserve for calcium in terrestrial vertebrates, a reserve that has acquired a major mechanical function. A major mechanism by which calcium is recognized to influence bone strength is through its effect on bone mass. Because bone functions as the calcium nutrient reserve, it follows inexorably that any depletion of that reserve (or failure to produce the genetically programmed skeletal mass during growth) would carry with it a corresponding decrease in bone strength. Calcium needed for critical cell metabolic functions is, in most cells, derived from intracellular stores of the mineral. The requirement for calcium is related to the protection of this mechanical function, not to the metabolic actions of calcium, which could be adequately protected by a reserve several orders of magnitude smaller. Lack of calcium is a key factor for occurrence of osteoporosis. Effective osteoporosis treatments involve a combination of pharmacotherapy designed to reverse the negative remodeling balance prevailing in the skeleton and physical therapy designed both to increase function and to increase mechanical loading on the skeleton.

Original languageEnglish
Title of host publicationPrinciples of Bone Biology, Two-Volume Set
PublisherElsevier Inc.
Pages1697-1710
Number of pages14
Volume2
ISBN (Print)9780123738844
DOIs
StatePublished - 2008

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Calcium
Bone
Bone and Bones
Skeleton
Nutrients
Osteoporosis
Physical therapy
Drug therapy
Food
Minerals
Vertebrates
Cations
Weights and Measures
Drug Therapy
Therapeutics
Growth

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Heaney, R. P. (2008). Calcium. In Principles of Bone Biology, Two-Volume Set (Vol. 2, pp. 1697-1710). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-373884-4.00010-0

Calcium. / Heaney, Robert P.

Principles of Bone Biology, Two-Volume Set. Vol. 2 Elsevier Inc., 2008. p. 1697-1710.

Research output: Chapter in Book/Report/Conference proceedingChapter

Heaney, RP 2008, Calcium. in Principles of Bone Biology, Two-Volume Set. vol. 2, Elsevier Inc., pp. 1697-1710. https://doi.org/10.1016/B978-0-12-373884-4.00010-0
Heaney RP. Calcium. In Principles of Bone Biology, Two-Volume Set. Vol. 2. Elsevier Inc. 2008. p. 1697-1710 https://doi.org/10.1016/B978-0-12-373884-4.00010-0
Heaney, Robert P. / Calcium. Principles of Bone Biology, Two-Volume Set. Vol. 2 Elsevier Inc., 2008. pp. 1697-1710
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