Calcium absorption response to cholecalciferol supplementation in hemodialysis

Laura A.G. Armas; Mohsen Zena; Richard Lund; Robert P. Heaney

doi:10.2215/CJN.08610812

Calcium absorption response to cholecalciferol supplementation in hemodialysis

Laura A.G. Armas, Mohsen Zena, Richard Lund, Robert P. Heaney

Department of Medicine

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Background and objectives Recent understanding of extrarenal production of calcitriol has led to the use of more vitaminD supplementation in CKD populations. This paper reports the effect of cholecalciferol supplementation on calcium absorption. Design, setting, participants, & measurements Paired calcium absorption tests were done before and after 12-13 weeks of 20,000 IUweekly cholecalciferol supplementation in 30 participants with stage 5 CKD on hemodialysis. The study was conducted from April to December of 2011. Calcium absorption was tested with a standardized meal containing 300 mg calcium carbonate intrinsically labeled with ⁴⁵Ca; 25-hydroxyvitamin D and 1,25- dihydroxyvitamin D were measured. Results 25-Hydroxyvitamin D rose from 14.2 ng/ml (11.5-18.5) at baseline to 49.3 ng/ml (42.3-58.1) at the end of the study (P

Original language	English (US)
Pages (from-to)	1003-1008
Number of pages	6
Journal	Clinical Journal of the American Society of Nephrology
Volume	8
Issue number	6
DOIs	https://doi.org/10.2215/CJN.08610812
State	Published - Jun 7 2013

All Science Journal Classification (ASJC) codes

Epidemiology
Critical Care and Intensive Care Medicine
Nephrology
Transplantation

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abstract = "Background and objectives Recent understanding of extrarenal production of calcitriol has led to the use of more vitaminD supplementation in CKD populations. This paper reports the effect of cholecalciferol supplementation on calcium absorption. Design, setting, participants, & measurements Paired calcium absorption tests were done before and after 12-13 weeks of 20,000 IUweekly cholecalciferol supplementation in 30 participants with stage 5 CKD on hemodialysis. The study was conducted from April to December of 2011. Calcium absorption was tested with a standardized meal containing 300 mg calcium carbonate intrinsically labeled with 45Ca; 25-hydroxyvitamin D and 1,25- dihydroxyvitamin D were measured. Results 25-Hydroxyvitamin D rose from 14.2 ng/ml (11.5-18.5) at baseline to 49.3 ng/ml (42.3-58.1) at the end of the study (P",

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AU - Armas, Laura A.G.

AU - Zena, Mohsen

AU - Lund, Richard

AU - Heaney, Robert P.

PY - 2013/6/7

Y1 - 2013/6/7

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Calcium absorption response to cholecalciferol supplementation in hemodialysis

Abstract

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