Calcium intake and disease prevention

Robert P. Heaney

Research output: Contribution to journalReview article

28 Citations (Scopus)

Abstract

While the fundamental metabolic function of calcium is to serve as a second messenger, coupling intracellular responses to extracellular signals, nutritional deficiency of calcium is manifested at a higher level of organization: 1) depletion of the calcium nutrient reserve; 2) inadequate complexation of digestive byproducts; and 3) collateral effects of hormones produced primarily to compensate for low calcium intake. The first mechanism contributes to the osteoporosis problem, the second to kidney stones and colon cancer, and the third to hypertension, preeclampsia, obesity, and insulin resistance, among others. Adequate calcium intakes (1000-1500 mg/d) in adults have been shown in controlled trials to lower the risk of osteoporotic fractures, kidney stones, obesity, and hypertension. The best source of calcium is dairy foods, largely because the disorders concerned depend upon multiple nutrients, not just calcium, and dairy provides a broad array of essential nutrients in addition to calcium, and at low cost.

Original languageEnglish
Pages (from-to)685-693
Number of pages9
JournalArquivos Brasileiros de Endocrinologia e Metabologia
Volume50
Issue number4
StatePublished - Aug 2006

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Calcium
Food
Kidney Calculi
Obesity
Hypertension
Osteoporotic Fractures
Kidney Neoplasms
Second Messenger Systems
Pre-Eclampsia
Malnutrition
Colonic Neoplasms
Osteoporosis
Insulin Resistance
Organizations
Hormones
Costs and Cost Analysis

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism

Cite this

Calcium intake and disease prevention. / Heaney, Robert P.

In: Arquivos Brasileiros de Endocrinologia e Metabologia, Vol. 50, No. 4, 08.2006, p. 685-693.

Research output: Contribution to journalReview article

Heaney, Robert P. / Calcium intake and disease prevention. In: Arquivos Brasileiros de Endocrinologia e Metabologia. 2006 ; Vol. 50, No. 4. pp. 685-693.
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