Calcium supplementation and incident kidney stone risk: A systematic review

Robert P. Heaney

Research output: Contribution to journalReview article

39 Citations (Scopus)

Abstract

Background: A report of a small increase in kidney stone risk in the calcium treatment arm of the Women's Health Initiative (WHI) led to a reduction in U.S. calcium supplement sales. Objective: To reassess kidney stone risk in postmenopausal women using data accumulated in calcium supplement trials, bone active agent registration trials, and in unpublished WHI data available online; and to compare these estimates with formal published epidemiological studies of stone risk. Methods: Literature review of published studies relating calcium intake to stone risk; adverse event report data from pharmaceutical industrial trials designed to evaluate bone active agents. Results: Stone risk in postmenopausal women has increased substantially in the past 40 years, but absolute population incidence estimates vary widely from a low of about 70 incidents/100,000/yr for Olmsted County, MN, today, to a concurrent high of approximately 190/100,000/yr for the Nurses' Health Study II. Reported WHI incidence rates are higher still, with values around 300/100,000/yr for various WHI subgroupings. The reasons for these discordances are unclear. Despite this uncertainty about background rate, most of the studies show no increase in stone risk with high calcium intake (from either diet or supplements). Contrariwise there is a substantial body of evidence, both from controlled trials and from observational studies, indicating that there is an inverse relationship between calcium intake and stone risk.

Original languageEnglish
Pages (from-to)519-527
Number of pages9
JournalJournal of the American College of Nutrition
Volume27
Issue number5
StatePublished - Oct 2008

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Kidney Calculi
Calcium
Women's Health
Bone and Bones
Incidence
Uncertainty
Observational Studies
Epidemiologic Studies
Nurses
Diet
Health
Pharmaceutical Preparations
Population

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Calcium supplementation and incident kidney stone risk : A systematic review. / Heaney, Robert P.

In: Journal of the American College of Nutrition, Vol. 27, No. 5, 10.2008, p. 519-527.

Research output: Contribution to journalReview article

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